周兆才 - 上海科技大学 - 生命科学与技术学院

个人简介

回国近5年来围绕STRIPAK超分子复合物，开展癌症与炎症信号机制研究，获得了前沿性成果：（1）解析STRIPAK复合物装配的基本结构特征，定义其整体不对称性以及激酶招募方式（论文以通讯作者发表在J Biol Chem，2014a；Cell子刊Structure，2013b；受邀发表综述在Curr Chem Biol, 2012）；（2）系统揭示STRIPAK复合物激酶组分MST的活性调控机制，并探讨其在细胞生长和迁移中功能作用（论文以通讯作者发表在J Biol Chem，2014b；J Struct Biol, 2014；Cell子刊Structure，2013a；受邀发表综述在Cell Mol Immunol, 2012）；（3）发现STRIPAK激酶组分MST信号通路（Hippo通路）中原癌蛋白YAP的一个天然拮抗蛋白VGLL4，解析三维结构，揭示功能机制，并设计发展了YAP的靶向抑制剂，为针对YAP/VGLL4比率失调的癌症提供一种新的个性化诊疗策略及途径（论文以通讯作者发表在Cancer Cell，2014，获Nature China专评；以共同通讯作者发表在Cell Res，2014；受邀发表综述在Acta Biochimica et Biophysica Sinica, 2014；以第一发明人申请专利1项）。

研究领域

癌症与炎症信号机制（中科院上海生命科学研究院生物化学与细胞生物学研究所研究员）

近期论文

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Shi Jiao, Huizhen Wang, Zhubing Shi, Aimei Dong, Wenjing Zhang, Xiaomin Song, Feng He, Yicui Wang, Zhenzhen Zhang, Wenjia Wang, Xin Wang, Tong Guo, Peixue Li, Yun Zhao, Hongbin Ji*, Lei Zhang*, Zhaocai Zhou*. Gastric Cancer Therapy by a Peptide Mimicking VGLL4 Function as a YAP Antagonist. Cancer Cell, 2014, 25: 166-180 (Highlighted by Nature China) Wenjing Zhang, Yijun Gao, Peixue Li, Zhubing Shi, Tong Guo, Fei Li, XiangKun Han, Yan Feng, Chao Zheng, Zuoyun Wang, Haiquan Chen, Zhaocai Zhou*, and Lei Zhang*, Hongbin Ji*. Identification of VGLL4 as a new tumor suppressor in lung cancer negatively regulating the YAP-TEADs transcriptional complex. Cell Res, 2014, 24: 331-343 Meng Zhang, Liang Dong, Zhubing Shi, Shi Jiao, Zhen Zhang, Wenqing Zhang, Guoguang Liu, Cuicui Chen, Miao Feng, Qiao Hao, Wenjia Wang, Mengxin Yin, Yun Zhao, Lei Zhang*, Zhaocai Zhou*. Structural mechanism of CCM3 heterodimerization with GCKIII kinases. Structure, 2013, 21: 680-688 Zhubing Shi, Shi Jiao, Zhen Zhang, Miao Ma, Zhao Zhang, Cuicui Chen, Ke Wang, Huizhen Wang, Lei Zhang, Yun Zhao*, Zhaocai Zhou*. Structure of the MST4 in complex with MO25 provides insights into its activation mechanism. Structure, 2013, 21: 449-561 Wenjia Wang, Zhubing Shi, Shi Jiao, Cuicui Chen, Huizhen Wang, Guoguang Liu, Qiang Wang, Yun Zhao, Mark I. Greene, Zhaocai Zhou*. Structural insights into SUN-KASH complexes across the nuclear envelope. Cell Res, 2012, 22: 1440-1452 (Cover story; Highlighted by AIMBN)