周斌 - 中国科学院分子细胞科学卓越创新中心 -

个人简介

2002年毕业于浙江大学医学院临床医学系获得MD。2006年毕业于中国医学科学院中国协和医科大学获得PhD。2006年至2010年在美国哈佛大学医学院波士顿儿童医院从事博士后研究，并于2009年任哈佛大学医学院讲师和Research Associate。2010年9月起至2016年8月任中国科学院上海生命科学研究院营养科学研究所研究员，研究组长。2016年9月起任职于中国科学院上海生命科学研究院生物化学与细胞生物学研究所研究员，研究组长。曾获得国际心脏研究会ISHR“杰出研究员奖”、国家杰出青年科学基金、 “英国皇家学会-牛顿高级学者基金”、中国青年科技奖、中国科学院青年科学家奖、谈家桢生命科学创新奖、树兰医学青年奖、科学探索奖、上海市自然科学牡丹奖等。多次获得中国科学院“优秀研究生指导教师”称号、“优秀导师奖”、“朱李月华优秀教师”奖等。

研究领域

谱系示踪与细胞命运可塑性研究工作研究组主要利用基于同源重组酶系统的遗传谱系示踪技术，在哺乳动物体内进行细胞标记及追踪来研究细胞起源及命运，揭示发育、疾病、再生过程中的细胞分化、增殖、衰老、死亡等细胞命运过程，并阐明细胞命运调控的分子机制，为相关疾病治疗提供重要理论基础和新的研究方向，解决了领域内多个重要科学问题，取得系统性原创成果。

近期论文

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He L, Pu W, Liu X, Zhang Z, Han M, Li Y, Huang X, Han X, Li Y, Liu K, Shi M, Lai L, Sun R, Wang Q-D, Ji Y, Tchorz JS, Zhou B*. Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair. Science 2021;6532:eabc4346. Han X, Zhang Z, He L, Zhu H, Li Y, Pu W, Han M, Zhao H, Liu K, Li Y, Huang X, Zhang M, Jin H, Lv Z, Tang J, Wang J, Sun R, Fei J, Tian X, Duan S, Wang Q, Wang L, He B, Zhou B*. A suite of new Dre-recombinase drivers markedly expands the ability to perform intersection genetic targeting. Cell Stem Cell 2021;28:1-17. Zhao H, Huang X, Liu Z, Pu W, Lv Z, He L, Li Y, Zhou Q, Lui KO, Zhou B*. Pre-existing beta cells but not progenitors contribute to new beta cells in the adult pancreas. Nat Metab 2021;3:352-365. Räsänen M, Sultan I, Paech J, Hemanthakumar KA, Yu W, He L, Tang J, Sun Y, Hlushchuk R, Huang X, Armstrong E, Khoma OZ, Mervaala E, Djonov V, Betsholtz C, Zhou B, Kivelä R, Alitalo K*. VEGF-B Promotes Endocardium-Derived Coronary Vessel Development and Cardiac Regeneration. Circulation 2021;143:65-77. Wang H, Zhao H, Zhu H, Li Y, Tang J, Li Y, Zhou B*. Sca1+ Cells Minimally Contribute to Smooth Muscle Cells in Atherosclerosis. Circ Res 2021;128:133-135. Tian X*, Zhou B*. Strategies for site-specific recombination with high efficiency and precise spatiotemporal resolution. Journal of Biological Chemistry 2021;296: S0021-9258(21)00285-4. Wu N, Sun H, Zhao X, Zhang Y, Tan J, Qi Y, Wang Q, Ng M, Liu Z, He L, Niu X, Chen L, Liu Z, Li HB, Zeng YA, Roulis M, Liu D, Cheng J, Zhou B, Ng LG, Zou D, Ye Y, Flavell RA, Ginhoux F, Su B*. MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche. Nature 2021;592:606-610 Jiang Z, Lu Z, Kou S, Feng T, Wei Y, Gao Z, Deng D, Meng J, Lin CP, Zhou B, Zhang H*. Overexpression of Kdr in adult endocardium induces endocardial neovascularization and improves heart function after myocardial infarction. Cell Res 2021;31:485-487. Jin H, Liu K, Tang J, Huang X, Wang H, Zhang Q, Zhu H, Li Y, Pu W, Zhao H, He L, Li Y, Zhang S, Zhang Z, Zhao Y, Qin Y, Pflanz S, Kasmi KEI, Zhang W, Liu Z, Ginhoux F, Ji Y, He B, Wang L, Zhou B*. Genetic fate-mapping reveals surface accumulation but not deep organ invasion of pleural and peritoneal cavity macrophages following injury. Nat Commun 2021;12 Zhou B*. Sinoatrial node pacemaker cells: cardiomyocyte- or neuron-like cells. Protein Cell 2021; doi: 10.1007/s13238-021-00827-w. Tang J, Wang H, Huang X, Li F, Zhu H, Li Y, He L, Zhang H, Pu W, Liu K, Zhao H, Bentzon JF, Yu Y, Ji Y, Nie Y, Tian X, Zhang L, Gao D, Zhou B*. Arterial Sca1+ Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration. Cell Stem Cell 2020;26:81-96.e4. Li Y, Lv Z, Zhang S, Wang Z, He L, Tang M, Pu W, Zhao H, Zhang Z, Shi Q, Cai D, Wu M, Hu G, Lui KO, Feng J, Nieto MA, Zhou B*. Genetic Fate Mapping of Transient Cell Fate Reveals N-Cadherin Activity and Function in Tumor Metastasis. Dev Cell 2020;54:593-607.e5. Vila Ellis L, Cain MP, Hutchison V, Flodby P, Crandall ED, Borok Z, Zhou B, Ostrin EJ, Wythe JD, Chen J*. Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung. Dev Cell 2020;52:617-630.e6. He L, Nguyen NB, Ardehali R, Zhou B*. Heart Regeneration by Endogenous Stem Cells and Cardiomyocyte Proliferation: Controversy, Fallacy, and Progress. Circulation 2020;142:275-291. Zhao H, Li Y, He L, Pu W, Yu W, Li Y, Wu YT, Xu C, Wei Y, Ding Q, Song BL, Huang H, Zhou B*. In Vivo AAV-CRISPR/Cas9-Mediated Gene Editing Ameliorates Atherosclerosis in Familial Hypercholesterolemia. Circulation 2020;141:67-79. Kong D, Wan Q, Li J, Zuo S, Liu G, Liu Q, Wang C, Bai P, Duan SZ, Zhou B, Gounari F, Lyu A, Lazarus M, Breyer RM, Yu Y*. DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells. Circulation 2020;141:655-666. Liu K, Tang M, Jin H, Liu Q, He L, Zhu H, Liu X, Han X, Li Y, Zhang L, Tang J, Pu W, Lv Z, Wang H, Ji H, Zhou B*. Triple-cell lineage tracing by a dual reporter on a single allele. J Biol Chem 2020;295:690-700. Li J, Liang C, Yang KY, Huang X, Han MY, Li X, Chan VW, Chan KS, Liu D, Huang ZP, Zhou B*, Lui KO*. Specific ablation of CD4+ T-cells promotes heart regeneration in juvenile mice. Theranostics 2020;10:8018-8035. Li H, Zhang Q, Gu Y, Wu Y, Wang Y, Wang L, Feng S, Hu Y, Zheng Y, Li Y, Ye H, Zhou B, Lin L, Liu M, Yang H, Li D*. Efficient photoactivatable Dre recombinase for cell type-specific spatiotemporal control of genome engineering in the mouse. Proc Natl Acad Sci U S A 2020;117:33426-33435. Wang Z, Zheng Y, Wang F, Zhong J, Zhao T, Xie Q, Zhu T, Ma F, Tang Q, Zhou B*, Zhu J*. Mfsd2a and Spns2 are essential for sphingosine-1-phosphate transport in the formation and maintenance of the blood-brain barrier. Science Advances 2020;6:eaay8627.