张雷 - 中国科学院大学 - 生命科学学院

个人简介

招生专业 071008-发育生物学招生方向发育过程的组织分化与生长调控细胞增殖与分化肿瘤发生，干细胞发育调控教育背景 2001-12--2009-01 美国西南医学中心博士后，助理讲师 1998-09--2001-06 中科院遗传与发育所博士 1995-09--1998-06 吉林大学酶工程国家重点实验室硕士 1991-09--1995-06 吉林大学分子生物学系，生化专业本科工作简历 2009-01~现在, 中科院上海生科院生化与细胞研究所, 研究员科研项目（ 1 ） YAP调控器官发育及稳态维持的分子机制研究, 主持, 国家级, 2016-01--2020-12 （ 2 ）细胞增殖与分化, 主持, 国家级, 2017-01--2021-12 （ 3 ）微环境信号调控肠干细胞干性的机制, 参与, 国家级, 2017-07--2021-12

研究领域

器官大小调控及组织稳态维持组织器官发育的大小最终取决于其组成细胞的数目、细胞大小及细胞间精确而复杂的排列组合，相关调控机制的异常将直接导致癌症等重大疾病的发生。Hippo信号通路是一条物种间高度保守的肿瘤抑制信号通路，是迄今被确认在调控器官发育大小、再生与重塑过程中起主导作用的信号通路。它不仅能通过调节细胞生长、增殖及凋亡来控制组织、器官的生长，还在组织稳态维持与干细胞的自我更新、分化等生命活动过程中发挥着极其重要的作用。已有研究表明，Hippo信号通路的突变或失衡可以导致包括癌症在内的多种疾病的发生。因此，阐明Hippo信号通路在器官大小调控及组织稳态维持中的作用将具有十分重要的理论与现实意义。本实验室主要利用遗传学、生物化学、分子与细胞生物学等研究手段，同时结合果蝇遗传模型与小鼠疾病模型，旨在从分子、细胞和动物水平解析Hippo等信号网络在调控细胞增殖、干细胞稳态与肿瘤发生中的功能及分子机制。我们的最终目标是揭示器官发育的大小调控机制与组织稳态维持机理，并在此基础上为癌症等疾病的诊断和治疗提供可行的方法和策略。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

（1） Lola regulates Drosophila adult midgut homeostasis via non-canonical Hippo signaling., eLife, 2020, 通讯作者（2） The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice., Hepatology, 2020, 通讯作者（3） Traffic jam regulates the function of the ovarian germline stem cell progeny differentiation niche during pre-adult stage in Drosophila., Scientific Reports, 2019, 通讯作者（4） VGLL4 plays a critical role in heart valve development and homeostasis., PLoS Genetics, 2019, 通讯作者（5） Glucocorticoid receptor signaling activates TEAD4 to promote breast cancer progression., Cancer Research, 2019, 通讯作者（6） Dual function of VGLL4 in muscle regeneration, EMBO Journal, 2019, 通讯作者（7） Staurosporine targets the Hippo pathway to inhibit cell growth, Journal of Molecular Cell Biology, 2018, 通讯作者（8） The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting cofactors VGLL4 and CtBP2 into a transcriptional complex., The Journal of Biological Chemistry, 2018, 通讯作者（9） Smurf downregulates Echinoid in the amnioserosa to regulate Drosophila dorsal closure., Genetics, 2017, 通讯作者（10） Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity., Development, 2017, 通讯作者（11） Taiman acts as a co-activator of Yorkie in the Hippo pathway to promote tissue growth and intestinal regeneration., Cell Discovery, 2016, 通讯作者（12） Involvement of the Hippo Pathway in Regeneration and Fibrogenesis after Ischemic Acute Kidney Injury: YAP is the Key Effector., Clinical Science, 2016, 通讯作者（13） Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded., Cell Discovery, 2016, 通讯作者（14） Importin α1 mediates Yorkie nuclear import via N-terminal non-canonical nuclear localization signal., The Journal of Biological Chemistry, 2016, 通讯作者（15） Control of growth and beyond: a special issue on Hippo signaling., Acta Biochimica et Biophysica Sinica, 2015, 通讯作者（16） Hippo signaling in epithelial stem cells., Acta Biochimica et Biophysica Sinica, 2015, 通讯作者（17） Growth Suppressor Lingerer Regulates bantam microRNA to Restrict Organ Size., Journal of Molecular Cell Biology, 2015, 通讯作者（18） Suppressor of Deltex mediates Pez degradation and modulates Drosophila midgut homeostasis., Nature Communications, 2015, 通讯作者（19） VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEADs transcriptional complex., Cell Research, 2014, 通讯作者（20） Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo., Developmental Biology, 2014, 通讯作者（21） A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer., Cancer Cell, 2014, 通讯作者（22） YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression., Nature Communications, 2014, 通讯作者（23） Drosophila Casein Kinase 2 (CK2) Promotes Warts Protein to Suppress Yorkie Protein Activity for Growth Control., The Journal of Biological Chemistry, 2014, 通讯作者（24） Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis., Cell Research, 2013, 通讯作者（25） Structural Mechanism of CCM3 Heterodimerization with GCKIII Kinases., Structure, 2013, 通讯作者（26） Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts is Essential for High Hh Activity Transduction, The Journal of Biological Chemistry, 2013, 通讯作者（27） Drosophila Ste-20 family protein kinase, Hippo, modulates Fat cell proliferation., PLoS One, 2013, 通讯作者（28） Drosophila Vps36 is involved in Hh signaling by regulating Smo trafficking., Journal of Cell Science, 2013, 通讯作者（29） Ter94 ATPase Complex Targets K11-Linked Ubiquitinated Ci to Proteasomes for Partial Degradation., Developmental Cell, 2013, 通讯作者（30） Atrophin/Rpd3 complex represses Hedgehog signaling by interacting with Ci., The Journal of Cell Biology, 2013, 通讯作者（31） A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity., Cell Research, 2013, 通讯作者（32） Par-1 regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association., PLoS Biology, 2013, 通讯作者（33） Brahma is essential for Drosophila Intestinal Stem Cell proliferation and regulated by Hippo signaling., eLife, 2013, 通讯作者（34） Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control., The Journal of Biological Chemistry, 2012, 通讯作者（35） Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus., Cell Research, 2011, 通讯作者（36） Hippo signaling, a hub of growth control, tumor suppression and pluripotency maintenance., Journal of Genetics and Genomics, 2011, 通讯作者（37） Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms., Developmental Biology, 2010, 第 2 作者（38） Hippo signaling pathway and organ size control., Fly, 2009, 第 1 作者（39） The TEAD/TEF family of transcription factor Scalloped mediates nuclear responses to the Hippo pathway in organ size control., Developmental Cell, 2008, 第 1 作者（40） Regulation of wingless signaling by the CKI family in Drosophila limb development., Developmental Biology, 2006, 第 1 作者（41） A Hedgehog-Induced BTB Protein Modulates Hedgehog Signaling by Degrading Ci/Gli Transcription Factor., Developmental Cell, 2006, 第 1 作者（42） Phosphorylation by Double-time/CKIε and CKIα targets Cubitus interruptus for Slimb/β-TRCP mediated proteolytic processing., Developmental Cell, 2005, 第 1 作者

学术兼职

2015-03-01-2020-02-29,上海科技大学特聘教授, 特聘教授