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研究领域

从事生物化学与分子生物学研究,研究方向为核酸与酶的相互作用。目前主要以tRNA和相关氨基酰-tRNA合成酶为对象进行研究。该项研究具有重要的生物学意义,可以为人类的疾病防止和治疗、改善人类生存环境提供理论依据和新的思路。

近期论文

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1. Qian Huang, Peng Yao, Gilbert Eriani and En-Duo Wang. In vivo identification of essential nucleotides in tRNALeu to its functions by using a constructed yeast tRNALeu knockout strain, Nucleic Acids Research, 2012, 20, 10463–10477. 2. Xiao-Long Zhou, Zhi-Rong Ruan, Qian Huang, Min Tan and En-Duo Wang. Translational fidelity maintenance preventing Ser mis-incorporation at Thr codon in protein from eukaryote, Nucleic Acids Research, 2013. 1(1):302-314. 3. Qing-Hua Hu, Qian Huang and En-Duo Wang. Crucial role of the C-terminal domain of Mycobacterium tuberculosis leucyl-tRNA synthetase in aminoacylation and editing, Nucleic Acids Research, 2013. 41(3):1859-1872. 4. Xin Chen, Jing-Jing Ma, Min Tan, Peng Yao, Qing-Hua Hu, Gilbert Eriani and En-Duo Wang. Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase. Nucleic Acids Research, 2011, 39(1), 235–247. 5. Xiao-Long Zhou, Dao-Hai Du, Min Tan, Hui-Yan Lei, Liang-Liang Ruan, Gilbert Eriani and En-Duo Wang. Role of tRNA amino acid-accepting end in aminoacylation and its quality control. Nucleic Acids Research, 2011, 39, 8857-8868.

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