个人简介
2002年获中国农业大学学士学位;2005年获中国农业大学硕士学位;2008年获中国农业大学博士学位;美国康涅狄格大学博士后。2008年至今在中国农业科学院北京畜牧兽医研究所工作。任中国畜牧兽医学会高级会员、中国畜牧兽医学会动物繁殖学分会理事。
研究领域
主要从事卵母细胞、胚胎发育机制与超低温冷冻相关研究工作,在家畜体外胚胎生产、卵母细胞/胚胎超低温冷冻保存方面取得了一定成果。
近期论文
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1. Ya-Han Zhao, Jing-Jing Wang, Pei-Pei Zhang, Hai-Sheng Hao, Yun-Wei Pang, Hao-Yu Wang, Wei-Hua Du, Shan-Jiang Zhao, Wei-Min Ruan, Hui-Ying Zou, Tong Hao, Hua-Bin Zhu, Xue-Ming Zhao. Oocytes in vitro maturation or vitrification significantly impaired DNA methylation patterns in their blastocysts analyzed by single cell whole genome methylation sequencing. Reprod Fertil Dev,2019. Accepted.
2. Li CY, Hao HS, Zhao YH, Zhang PP, Wang HY, Pang YW, Du WH, Zhao SJ, Liu Y, Huang JM, Wang JJ, Ruan WM,Hao T, Reiter RJ, Zhu HB, Zhao XM. Melatonin Improves the Fertilization Capacity of Sex-Sorted Bull Sperm by Inhibiting Apoptosis and Increasing Fertilization Capacitation via MT1. Int J Mol Sci. 2019;20(16).
3. Li CY, Zhao YH, Hao HS, Wang HY, Huang JM, Yan CL, Du WH, Pang YW, Zhang PP, Liu Y, Zhu HB, Zhao XM. Resveratrol significantly improves the fertilisation capacity of bovine sex-sorted semen by inhibiting apoptosis and lipid peroxidation. Sci Rep. 2018; 8(7603).
4. Zhao XM, Wang N, Hao HS, Li CY, Zhao YH, Yan CL, Wang HY, Du WH, Wang D, Liu Y, Pang YW, Zhu HB. Melatonin improves the fertilization capacity and developmental ability of bovine oocytes by regulating cytoplasmic maturation events. J Pineal Res.2018;64(1).
5. Wang N, Hao HS, Li CY, Zhao YH, Wang HY, Yan CL, Du WH, Wang D, Liu Y, Pang YW, Zhu HB, Zhao XM. Calcium ion regulation by BAPTA-AM and ruthenium red improved the fertilisation capacityand developmental ability of vitrified bovine oocytes. Sci Rep.2017; 7(1): 10652.
6. Zhao XM, Hao HS, Du WH, Zhao SJ, Wang HY, Wang N, Wang D, Liu Y, Qin T, Zhu HB. Melatonin inhibits apoptosis and improves the developmental potential of vitrified bovine oocytes. J Pineal Res 2016;60(2):132-41.
7. Zhao XM, Hao HS, Du WH, Zhu HB*. Effect of vitrification on the microRNA transcriptome in mouse blastocysts. PLoS One. 2015;10:e0123451.
8. Zhao XM, Ren JJ, Du WH, Hao HS, Wang D, Qin T, Liu Y, Zhu HB. Effect of vitrification on promoter CpG island methylation patterns and expression levels of DNA methyltransferase 1o, histone acetyltransferase 1, and deacetylase 1 in metaphase II mouse oocytes. Fertil Steril. 2013; 100: 256-261.、
9. Zhao XM, Ren JJ, Du WH, Hao HS, Wang D, Qin T, Liu Y, Zhu HB. Effect of 5-aza-2′- deoxycytidine on methylation of the putative imprinted control region of H19 during the in vitro development of vitrified bovine two-cell embryos. Fertil Steril.2012;98:222-227.
10. Zhao XM, Du WH, Hao HS,Wang D, Liu Y, Qin T, Zhu HB. Effect of vitrification on promoter methylation and the expression of pluripotency and differentiation genes in mouse blastocysts. Mol Reprod Dev. 2012;79:445- 450.
学术兼职
现任家畜胚胎工程与繁殖创新团队骨干专家;任国家自然基金及中华农业科技奖评审专家、国家科技专家库入库专家、中国畜牧兽医学会高级会员、中国畜牧兽医学会动物繁殖学分会理事