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研究领域

1. 去乙酰化去甲基化双重作用的新型赖氨酸修饰酶的研究; 2. Stem cell跨膜蛋白受体及胞内信号蛋白乙酰化和甲基化功能的研究; 3.细胞受体-STAT信号转导的蛋白质译后修饰的肿瘤转移研究; 4. 肿瘤转移干细胞中的乙酰化调控。正常细胞和肿瘤细胞的对立,互根,消长,和转化的研究。

近期论文

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1. Tang X, Gao JS, Guan YJ, McLane KE, Yuan ZL, Ramratnam B, Chin YE. Acetylation-dependent signal transduction for type I interferon receptor. Cell. 2007;131(1):93-105. 2. Ma L, Gao JS, Guan Y, Shi X, Zhang H, Ayrapetov MK, Zhang Z, Xu L, Hyun YM, Kim M, Zhuang S, Chin YE. Acetylation modulates prolactin receptor dimerization. Proc Natl Acad Sci U S A. 2010;107(45):19314-9. 3. Guan YJ, Zhang Z, Yu C, Ma L, Hu W, Xu L, Gao JS, Chung CS, Wang L, Yang ZF, Fast LD, Chung AS, Kim M, Ayala A, Zhuang S, Zheng S, Chin YE. Phospho-SXXE/D motif mediated TNF receptor 1-TRADD death domain complex formation for T cell activation and migration. J Immunol. 2011;187(3):1289-97. 4. Qi H, Zhu H, Lou M, Fan Y, Liu H, Shen J, Li Z, Lv X, Shan J, Zhu L, Chin YE*, Shao J.* Interferon regulatory factor 1 transactivates expression of human DNA polymerase η in response to carcinogen N-methyl-N'-nitro-N-nitrosoguanidine. J Biol Chem. 2012;287(16):12622-33. (*equal corresponding authors). 5. Lang JY, Shi Y, Chin YE. Reprogramming cancer cells: back to the future. Oncogene. 2012 Aug 6. 349.

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