刘雪松 - 上海科技大学 - 生命科学与技术学院

个人简介

2002年本科毕业于武汉大学生命科学学院。 2007年在中科院上海生命科学研究院健康科学研究所获博士学位。 2008年至2015年在美国哈佛大学医学院以及公共卫生学院从事博士后研究工作。 2015年6月加入上海科技大学生命科学与技术学院任助理教授、研究员

研究领域

癌症生物学

实验室主要研究方向是肿瘤分子遗传和免疫基因组学。研究内容包括：1，肿瘤分子遗传，结合小鼠模型，生化细胞手段研究肿瘤新靶标和机制。研究新肿瘤特异基因、新肿瘤DNA变异的功能；制备新式肿瘤小鼠模型，精确模拟由体细胞多基因突变引发的人类肿瘤。2，肿瘤免疫基因组，从肿瘤基因组角度研究免疫治疗的标志物和靶标。发现新的肿瘤基因组标志物以高效区分免疫治疗有反应和不反应病人；提高肿瘤细胞免疫原性，把免疫治疗不反应病人变成有反应病人。研究手段有：肿瘤基因组生物信息学分析、生化细胞技术和小鼠模型。详情可参考实验室主页：http://liuxslab.slst.shanghaitech.edu.cn

近期论文

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#Firstauthor;*Correspondingauthor. 22.WangS(#),CowleyLA(#),LiuXS(*).SexDifferencesinCancerImmunotherapyEfficacy,Biomarkers,and TherapeuticStrategy.Molecules 2019,24,3214. 21.WangS,LiuXS.TheUCSCXenaToolsRpackage:atoolkitforaccessinggenomicsdatafromUCSCXena platform,fromcancermulti-omicstosingle-cellRNA-seq.JournalofOpenSourceSoftware,4(40),1627,(2019). 20.HeZ(#),WangS(#),ShaoY(#),ZhangJ(#),WuX,ChenY,HuJ,ZhangF,LiuXS(*).RasdownstreameffectorGGCTalleviatesoncogenicstress.iScience 2019Jul26;19:256-266. 19.WangS(#),ZhangJ,HeZ,WuK,LiuXS(*).Thepredictivepoweroftumormutationalburdeninlungcancer immunotherapyresponseisinfluencedbypatients'sex.IntJCancer.2019Apr10.doi:10.1002/ijc.32327. 18.WangSX(#),JiaMM(#),HeZK,LiuXS(*).APOBEC3BandAPOBECmutationalsignatureaspotential predictivemarkersforimmunotherapyresponseinnon-smallcelllungcancer.Oncogene. 2018Jul;37(29):3924-3936. 17.GerarduzziC(#),dePoloA,LiuXS,ElKharbiliM,LittleJB,YuanZM(*).Humanepidermalgrowthfactorreceptor4(Her4)Suppressesp53ProteinviaTargetingtheMDMX-MDM2ProteinComplex:IMPLICATIONOFANOVELMDMXSER-314PHOSPHOSITE.JBiolChem.2016Dec9;291(50):25937-25949. 16.ChenM(#),ZhangJ,SampieriK,ClohessyJG,MendezL,Gonzalez-BillalabeitiaE,LiuXS,LeeYR,FungJ, KatonJM,MenonAV,WebsterKA,NgC,PalumbieriMD,DiolombiMS,BreitkopfSB,Teruya-FeldsteinJ, SignorettiS,BronsonRT,AsaraJM,Castillo-MartinM,Cordon-CardoC,PandolfiPP(*).Anaberrant SREBP-dependentlipogenicprogrampromotesmetastaticprostatecancer.NatGenet.2018Feb;50(2):206-218. 15. LiuXS(#),LiuZ,GerarduzziC,ChoiDE,GanapathyS,PandolfiPP,YuanZM(*).SomatichumanZBTB7A zincfingermutationspromotecancerprogression.Oncogene.2016Jun9;35(23):3071-8. doi:10.1038/onc.2015.371. 14. LiuXS (#),ChandramoulyG,RassE,GuanY,WangG,HobbsRM,RajendranA,XieA,ShahJV,DavisAJ, ScullyR(*),LunardiA (#,*),PandolfiPP(*).LRFmaintainsgenomeintegritybyregulatingthenon-homologous endjoiningpathwayofDNArepair.NatureCommunications.2015Oct8;6:8325.doi:10.1038/ncomms9325. 13. LiuXS(#),GenetMD,HainesJE,MehannaEK,WuS,ChenHI,ChenY,QureshiAA,HanJ,ChenX, FisherDE,PandolfiPP,YuanZM(*).ZBTB7AsuppressesmelanomametastasisbytranscriptionallyrepressingMCAM. MolCancerRes.2015,13(8):1206-17. 12.LiuXS(#),LittleJB,YuanZM(*).Glycolyticmetabolisminfluencesglobalchromatinstructure.Oncotarget. 2015,6(6):4214-25. 11.LiuXS(#),HainesJE,MehannaEK,GenetMD,Ben-SahraI,AsaraJM,ManningBD,YuanZM(*).ZBTB7A actsasatumorsuppressorthroughthetranscriptionalrepressionofglycolysis.GenesDev.2014,28(17):1917-28.(HighlightedinNatureReviewsCancer:IsabelLokody,NatureReviewsCancer,14,649(2014)) 10.González-BillalabeitiaE(#),SeitzerN(#),SongSJ,SongMS,PatnaikA,LiuXS,EppingMT,PapaA,Hobbs RM,ChenM,LunardiA,NgC,WebsterKA,SignorettiS,LodaM,AsaraJM,NardellaC,ClohessyJG,CantleyLC,PandolfiPP(*).VulnerabilitiesofPTEN-TP53-deficientprostatecancerstocompoundPARP-PI3Kinhibition. CancerDiscov. 2014,4(8):896-904. 9.WangG(#),LunardiA(#),ZhangJ,ChenZ,AlaU,WebsterKA,TayY,Gonzalez-BillalabeitiaE,EgiaA,ShafferDR,CarverB,LiuXS,TaulliR,KuoWP,NardellaC,SignorettiS,Cordon-CardoC,GeraldWL,PandolfiPP(*). Zbtb7asuppressesprostatecancerthroughrepressionofaSox9-dependentpathwayforcellularsenescence bypassandtumorinvasion.NatGenet. 2013,45(7):739-46. 8.ZhangHX(#),LiuZX(#),SunYP(#),ZhuJ,LuSY,LiuXS,HuangQH,XieYY,ZhuHB,DangSY,ChenHF, ZhengGY,LiYX,KuangY,FeiJ,ChenSJ,ChenZ(*),WangZG(*).Rig-IregulatesNF-κBactivitythroughbinding toNf-κb13'-UTRmRNA.ProcNatlAcadSciUSA. 2013,110(16):6459-64. 7. LiuXS (#),ZhaoXD(#),WangX(#),YaoYX,ZhangLL,ShuRZ,RenWH,HuangY,HuangL,GuMM,KuangY,WangL,LuSY,ChiJ,FenJS,WangYF,FeiJ,DaiW(*),WangZG(*).GerminalCellAplasiainKif18a MutantMaleMiceDuetoImpairedChromosomeCongressionandDysregulatedBubR1andCENP-E.GenesCancer. 2010,1(1):26-39.(*co-firstauthor)(Highlightedascoverstory) 6.ShuRZ(#),ZhangF,LiuXS,LiCL,WangL,TaiYL,WuXL,YangX,LiaoXD,JinY,GuMM,HuangL,PangXF,WangZG(*).Targetdeletionofthecytoskeleton-associatedproteinpalladindoesnotimpairneuriteoutgrowthinmice.PLoSOne. 2009,4(9):e6916. 5.WuXL(#),GuMM(#),HuangL,LiuXS,ZhangHX,DingXY,XuJQ,CuiB,WangL,LuSY,ChenXY,Zhang HG,HuangW,YuanWT,YangJM,GuQ,FeiJ,ChenZ,YuanZM,WangZG(*).Multiplesynostosessyndromeis duetoamissensemutationinexon2ofFGF9gene.AmJHumGenet. 2009,85(1):53-63. 4.WangY(#),ZhangHX,SunYP,LiuZX,LiuXS,WangL,LuSY,KongH,LiuQL,LiXH,LuZY,ChenSJ,ChenZ,BaoSS,DaiW,WangZG(*).Rig-I-/-micedevelopcolitisassociatedwithdownregulationofGalphai2.CellRes. 2007,17(10):858-68. 3. LiuXS(#),LiXH,WangY,ShuRZ,WangL,LuSY,KongH,JinYE,ZhangLJ,FeiJ,ChenSJ,ChenZ,GuMM,LuZY,WangZG(*).Disruptionofpalladinleadstodefectsindefinitiveerythropoiesisbyinterferingwitherythroblas-ticislandformationinmousefetalliver.Blood.2007,110(3):870-76. 2.LiuXS(#),LuoHJ,YangH,WangL,KongH,JinYE,WangF,GuMM,ChenZ,LuZY,WangZG(*).Palladin regulatescellandextracellularmatrixinteractionthroughmaintainingnormalactincytoskeletonarchitectureand stabilizingbeta1-integrin.JCellBiochem.2007,100(5):1288-300. 1.LuoH(#),LiuX(#),WangF,HuangQ,ShenS,WangL,XuG,SunX,KongH,GuM,ChenS,ChenZ, WangZ(*).Disruptionofpalladinresultsinneuraltubeclosuredefectsinmice.MolCellNeurosci. 2005,29(4):507-15