肖俊宇 - 北京前沿交叉学科研究院 -

研究领域

我们关注细胞内受磷酸化调控的各种过程。在近期工作中，我们研究了一类分泌系统内的新型激酶，系统阐明了其中多个成员的功能和调控机制，并揭示了它们与人体疾病的关系。同时，我们也关注脂肪代谢过程中的关键酶和复合体。最近，我们利用冷冻电镜技术，解析了人源线粒体三功能酶近原子分辨率的结构，阐明了其组装方式及与线粒体内膜结合的机制。

近期论文

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1.Liang, K., Li, N., Wang, X., Dai, J., Liu, P., Wang, C., Chen, X.W., Gao, N., Xiao, J.* (2018). Cryo-EM structure of human mitochondrial trifunctional protein. Proc Natl Acad Sci U S A 115:7039-7044. 2.Zhang, H., Zhu, Q., Cui, J., Wang, Y., Chen, M.J., Guo, X., Tagliabracci, V.S., Dixon, J.E., Xiao, J.* (2018). Structure and evolution of the Fam20 kinases. Nature Communications 9:1218. 3.Liu, Y., Bhowmick, T., Liu, Y., Gao, X., Mertens, H.D.T., Svergun, D.I., Xiao, J.*, Zhang, Y.*, Wang, J.H.*, Meijers, R*. (2018). Structural Basis for Draxin-Modulated Axon Guidance and Fasciculation by Netrin-1 through DCC. Neuron. 97(6):1261-1267. 4.Du, S., Qu, L.J., Xiao, J.* (2018). Crystal structures of the extracellular domains of the CrRLK1L receptor-like kinases ANXUR1 and ANXUR2. Protein Sci. 27:886-892. 5.Sun, X., Li, Y., He, W., Ji, C., Xia, P., Wang, Y., Du, S., Li, H., Raikhel, N., Xiao, J.*, Guo, H.* (2017). Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase. Nature Communications 8:15758. 6.Cui, J., Zhu, Q., Zhang, H., Cianfrocco, M.A., Leschziner, A.E., Dixon, J.E.*, Xiao, J.* (2017). Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding. eLife 6, e23990. 7.Zhu, Q., Venzke, D., Walimbe, A.S., Anderson, M.E., Fu, Q., Kinch, L.N., Wang, W., Chen, X., Grishin, N.V., Huang, N., Yu, L., Dixon, J.E., Campbell, K.P.*, Xiao, J.* (2016). Structure of protein O-mannose kinase reveals a unique active site architecture. eLife 5, e22238. 8.Tagliabracci, V.S.*, Wen, J., Xiao, J.* (2016). Methods to Purify and Assay Secretory Pathway Kinases. Methods Mol Biol 1496:197-215.