林一瀚 - 北京前沿交叉学科研究院 -

研究领域

本实验室聚焦干细胞、免疫细胞、及肿瘤细胞的异质性和细胞命运决策机制。通过发展新型的定量单细胞实验与分析技术，并结合系统生物学方法与合成生物学手段，在单细胞水平上研究细胞异质性及命运决策的关键调控要素，以期在单细胞水平上深入理解发育、免疫、疾病等重要过程，并进一步利用药物或合成生物器件对这些过程进行精准干预。近期具体研究方向包括：新型单细胞工具的开发（single-cell techniques）；基因转录调控的噪音与动力学（noise and dynamics）；转录调控中的相分离现象（phase separation）；表观调控机制（epigenetic regulation）；基因网络中的反馈回路（feedback loops）；干细胞稳态维持及分化（homeostasis and differentiation）。

近期论文

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1. Jiegen Wu, Xu Han, Haotian Zhai, Tingyu Yang, Yihan Lin*. Evidence for rate-dependent filtering of global extrinsic noise by biochemical reactions in mammalian cells. Molecular Systems Biology 2020, 16, e9335 (*corresponding author). 2. Jianhan Zhang#, Xu Han#, Yihan Lin*, Dissecting the regulation and function of ATP at the single-cell level, PLOS Biology 2018, 16(12): e3000095 (*corresponding author) 3. Rosa Martinez-Corral, Elba Raimundez, Yihan Lin, Michael B. Elowitz, Jordi Garcia-Ojalvo*, Self-amplifying pulsatile protein dynamics without positive feedback, Cell Systems 2018, 7(4): 453-462 4. Jin Park, Marta Dies, Yihan Lin, Sahand Hormoz, …, Michael B. Elowitz*, Molecular time sharing through dynamic pulsing in single cells, Cell Systems 2018, 6(2): 216-229 Prior to PKU: 5. Yihan Lin, Chang Ho Sohn, Chiraj K. Dalal, Long Cai & Michael B. Elowitz*. Combinatorial gene regulation by modulation of relative pulse timing, Nature 2015, 527(7576):54-58 6. Joseph H. Levine#, Yihan Lin#, & Michael B. Elowitz*. Functional roles of pulsing in genetic circuits. Science, 342(6163): 1193-1200, 2013 (# co-first author) 7. Yihan Lin and Michael B. Elowitz*, Central dogma goes digital, Molecular Cell, 61: 791-792, 2016. 8. Yihan Lin, Ying Li, Sean Crosson, Aaron R. Dinner* & Norbert F. Scherer*, Phase resetting reveals network dynamics underlying a bacterial cell cycle, PLOS Computational Biology, 8(11): e1002778, 2012 9.Yihan Lin, Sean Crosson* & Norbert F. Scherer*, Single-gene tuning of Caulobacter cell cycle period and noise, swarming motility, and surface adhesion, Molecular Systems Biology, 6: 445, 2010.