季雄 - 北京前沿交叉学科研究院 -

研究领域

研究兴趣包括基因表达调控，三维功能基因组和非编码RNA。以早期胚胎干细胞和癌症细胞为模型，运用基因组学，蛋白质组学，生物信息学，基因组编辑，生物成像和生物化学等多学科技术开展染色体结构调控的分子机制，动态变化和疾病的相关研究。本实验室将致力于：1，染色质结构和调控因子的系统鉴定。2，单细胞和全基因组水平上染色质结构装配与动态调控研究。3，研究干细胞命运决定，细胞周期以及疾病发生过程中的染色质结构的分子机制和结构基础。

近期论文

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1. Ji, X., Dadon, D.B., Powell, B.E., Fan, Z.P., Borges-Rivera, D., Shachar, S., Weintraub, A.S., Hnisz, D., Pegoraro, G., Lee, T.I., et al. (2016). 3D Chromosome Regulatory Landscape of Human Pluripotent Cells. Cell Stem Cell 18, 262-275. 2. Ji, X., Dadon, D.B., Abraham, B.J., Lee, T.I., Jaenisch, R., Bradner, J.E., and Young, R.A. (2015). Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions. Proceedings of the National Academy of Sciences of the United States of America 112, 3841-3846. 3. Ji, X., Zhou, Y., Pandit, S., Huang, J., Li, H., Lin, C.Y., Xiao, R., Burge, C.B., and Fu, X.D. (2013). SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell 153, 855-868. 4. Liu, X.S., Wu, H., Ji, X., Stelzer, Y., Wu, X., Czauderna, S., Shu, J., Dadon, D., Young, R.A., and Jaenisch, R. (2016). Editing DNA Methylation in the Mammalian Genome. Cell 167, 233-247 e217. 5. Sigova, A.A., Abraham, B.J., Ji, X., Molinie, B., Hannett, N.M., Guo, Y.E., Jangi, M., Giallourakis, C.C., Sharp, P.A., and Young, R.A. (2015). Transcription factor trapping by RNA in gene regulatory elements. Science 350, 978-981.