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Zuo EW*, Sun YD, Yuan TL, He BB, Zhou CY, Ying WQ, Liu J, Wei W, Zeng R, Li YX*, Yang H*. A rationally engineered cytosine base editor retains high on-target activity while reducing both DNA and RNA off-target effects. Nat Methods 2020;17(6):600-604
Li CY, Lu WL, Yang LG, Li ZW, Zhou XY, Guo R, Wang JQ, Wu ZB, Dong ZY, Ning G, Shi YJ, Gu YM, Chen P, Hao ZJ, Han TT, Yang MQ, Wang W, Huang XH, Li YX*, Gao S*, Hu RG*. MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3. National Science Review 2020;7:671-685
Zuo E, Sun Y, Wei W, Yuan T, Ying W, Sun H, Yuan L, Steinmetz LM*, Li Y*, Yang H*. Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos. Science 2019;364(6437):289-292
Zhou C, Sun Y, Yan R, Liu Y, Zuo E, Gu C, Han L, Wei Y, Hu X, Zeng R, Li Y*, Zhou H*, Guo F*, Yang H*. Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis. Nature 2019;571(7764):275-278
Qiu Z, Li H, Zhang Z, Zhu Z, He S, Wang X, Wang P, Qin J, Zhuang L, Wang W, Xie F, Gu Y, Zou K, Li C, Li C, Wang C, Cen J, Chen X, Shu Y, Zhang Z, Sun L, Min L, Fu Y, Huang X, Lv H, Zhou H, Ji Y, Zhang Z, Meng Z, Shi X*, Zhang H*, Li Y*, Hui L*. A Pharmacogenomic Landscape in Human Liver Cancers. Cancer Cell 2019;36(2):179-193
Li W, Yang L, He Q, Hu C, Zhu L, Ma X, Ma X, Bao S, Li L, Chen Y, Deng X, Zhang X, Cen J, Zhang L, Wang Z, Xie WF, Li H*, Li Y*, Hui L*. A Homeostatic Arid1a-Dependent Permissive Chromatin State Licenses Hepatocyte Responsiveness to Liver-Injury-Associated YAP Signaling. Cell Stem Cell 2019;25(1):54-68.e5
Benpeng Miao, Zhen Wang*, Yixue Li*. Genomic Analysis Reveals Hypoxia Adaptation in the Tibetan Mastiff by Introgression of the Gray Wolf from the Tibetan Plateau, Mol Biol Evol 2017;34(3):734-743
Li Mao#, Chenglin Liu#, Zhen Wang, Xiaofeng Niu, Liang Xue, Zhilei Zhou, Zhenying Cai, Meng Yu, Yixue Li*, Dianqing Wu*, Lin Li*. A genome-wide loss-of-function screening method for minimizing false-negatives caused by functional redundancy. Cell research 2016;26(9):1067-1070
Xiao Gou#, Zhen Wang#, Ning Li#, Feng Qiu#, Ze Xu, Dawei Yan, Shuli Yang, Jia Jia, Xiaoyan Kong, Zehui Wei, Shaoxiong Lu, Linsheng Lian, Changxin Wu, Xueyan Wang, Guozhi Li, Teng Ma, Qiang Jiang, Xue Zhao, Jiaqiang Yang, Baohong Liu, Dongkai Wei, Hong Li, Jianfa Yang, Yulin Yan, Guiying Zhao, Xinxing Dong, Mingli Li, Weidong Deng, Jing Leng, Chaochun Wei, Chuan Wang, Huaming Mao*, Hao Zhang*, Guohui Ding*, Yixue Li*. Whole-genome sequencing of six dog breeds from continuous altitudes reveals adaptation to high-altitude hypoxia. Genome Res 2014;24(8):1308-1315
Zhijian Cao#, Yao Yu#, Yingliang Wu#, Pei Hao#, Zhiyong Di#, Yawen He#, Zongyun Chen, Weishan Yang, Zhiyong Shen, Xiaohua He, Jia Sheng, Xiaobo Xu, Bohu Pan, Jing Feng, Xiaojuan Yang, Wei Hong, Wenjuan Zhao, Zhongjie Li, Kai Huang, Tian Li, Yimeng Kong, Hui Liu, Dahe Jiang, Binyan Zhang, Jun Hu, Youtian Hu, Bin Wang, Jianliang Dai, Bifeng Yuan, Yuqi Feng, Wei Huang, Xiaojing Xing, Guoping Zhao, Xuan Li*, Yixue Li*, Wenxin Li*. The genome of Mesobuthus martensii reveals a unique adaptation model of arthropods, Nat Commun 2013;4:2602
Yunwen Hu#, Shuihua Lu, Zhigang Song#, Wei Wang#, Pei Hao#, Jianhua Li#, Xiaonan Zhang#, Huiling Yen, Bisheng Shi, Tao Li, Wencai Guan, Lei Xu, Yi Liu, Sen Wang, Xiaoling Zhang, Di Tian, Zhaoqin Zhu, Jing He, Kai Huang, Huijie Chen, Lulu Zheng, Xuan Li, Jie Ping, Bin Kang, Xiuhong Xi, Lijun Zha, Yixue Li, Zhiyong Zhang, Malik Peirisx*, Zhenghong Yuan*. Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet 2013;381(9885):2273-2279
Huaixing Li#, Wei Gan#, Ling Lu#, Xiao Dong#, Xueyao Han#, Cheng Hu#, Zhen Yang#, Liang Sun#, Wei Bao#, Pengtao Li#, Meian He, Liangdan Sun, Yiqin Wang, Jingwen Zhu, Qianqian Ning, Yong Tang, Rong Zhang, Jie Wen, Di Wang, Xilin Zhu, Kunquan Guo, Xianbo Zuo, Xiaohui Guo, Handong Yang, Xianghai Zhou, DIAGRAM Consortium, AGEN-T2D Consortium, Xuejun Zhang, Lu Qi, Ruth J.F. Loos, Frank B. Hu, Tangchun Wu, Ying Liu, Liegang Liu, Ze Yang, Renming Hu, Weiping Jia, Linong Ji, Yixue Li*, Xu Lin*. A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes 2013;62(1):291-298
Jirimutu#, Zhen Wang#, Guohui Ding#, Gangliang Chen#, Yamin Sun#, Zhihong Sun#, Heping Zhang, Lei Wang, Surong Hasi, Yan Zhang, Jianmei Li, Yixiang Shi, ZeXu, Chuan He, Siriguleng Yu, Shengdi Li, Wenbin Zhang, Mijiddorj Batmunkh, Batsukh Ts, Narenbatu, Unierhu, Shirzana Bat-Ireedui, Hongwei Gao, Banzragch Baysgalan, Qing Li, Zhiling Jia, Turigenbayila,Subudenggerile, Narenmanduhu, Zhaoxia Wang, Juan Wang, Lei Pan, Yongcan Chen, Yaichil Ganerdene, Dabxilt, Erdemt, Altansha, Altansukh, Tuya Liu, Minhui Cao, Aruuntsever, Bayart, Hosblig, Fei He, A Zha-ti, Guangyong Zheng, Feng Qiu, Zikui Sun, Lele Zhao,Wenjing Zhao, Baohong Liu, Chao Li, Yunqin Chen, Xiaoyan Tang, Chunyan Guo, Wei Liu, Liang Ming, Temuulen, Aiying Cui, YiLi, Junhui Gao, Jing Li, Wurentaodi, Shen Niu, Tao Sun, Zhengxiao Zhai, Min Zhang, Chen Chen, Tunteg Baldan, Tuman Bayaer, Yixue Li*, He Meng*. Genome sequences of wild and domestic bactrian camels. Nature communications 2012;3:1202
Zhen Wang#, Guohui Ding#, Ludwig Geistlinger, Hong Li, Lei Liu, Rong Zeng*, Yoshio Tateno*, Yixue Li*. Evolution of protein phosphorylation for distinct functional modules in vertebrate genomes. Molecular biology and evolution 2011;28(3):1131-1140
Shimin Zhao, Wei Xu,Wenqing Jiang, Wei Yu, Yan Lin, Tengfei Zhang, Jun Yao, Li Zhou, Yaxue Zeng, Hong Li, Yixue Li, Jiong Shi, Wenlin An, Susan M. Hancock, Fuchu He, Lunxiu Qin, Jason Chin, Pengyuan Yang, Xian Chen, Qunying Lei, Yue Xiong*, Kunliang Guan*. Regulation of cellular metabolism by protein lysine acetylation. Science 2010;327(5968):1000-1004
Ruoyu Luo#, Haibin Wei#, Lin Ye, Kankan Wang, Fan Chen, Lijun Luo, Lei Liu, Yuanyuan Li, M. James C. Crabbe, Li Jin, Yixue Li*, Yang Zhong*. Photosynthetic metabolism of C3 plants shows highly cooperative regulation under changing environments: a systems biological analysis. Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):847-852
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