研究领域
1. 研究人类端粒结合蛋白调控端粒结构与端粒酶的分子机制； 2. 研究端粒与DNA修复因子的关系； 3. 研究表观遗产调控过程中重要蛋白质复合物的结构与功能。
近期论文
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1. Huang J, Gurung B, Wan B, Matkar S, Veniaminova NA, Merchant JL, Hua X and Lei M* (2012). The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature482: 542-546.
2. Zeng Z, Min B, Huang J, Hong K, Yang Y, Collins K and Lei M* (2011). Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA. Proc Natl Acad Sci USA 108: 20357- 20361.
3. Chen Y, Rai R, Zhou Z, Kanoh J, Ribeyre C, Yang Y, Zheng H, Damay P, Wang F, Tsujii H, Hiraoko Y, Shore D, Hu H, Chang S and Lei M* (2011). A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms. Nat Struct Mol Biol 18:213-228.
4. Zeng Z, Wang W, Yang Y, Chen Y, Yang X, Diehl J, Liu X and Lei M* (2010). Structural basis of selective ubiquitination of TRF1 by SCFFbx4. Dev Cell 18: 214-225.
5. Sun J, Yu EY, Yang Y, Confer LA, Sun SH, Wan K, Lue NF and Lei M* (2009). Stn1-Ten1 is an Rpa2-Rpa3-like complex at telomeres. Genes Dev. 23: 2900-2914.
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