个人简介
陈丽红,教授,博士研究生导师,辽宁省“兴辽英才计划”创新领军人才,辽宁省“百千万人才工程”千层次人选,大连市地方级领军人才。北京大学病理生理学博士,美国宾夕法尼亚大学博士后、助理研究员,现任大连医科大学医学科学研究院特聘研究员。以第一作者和通讯作者身份在在Circulation、Science Translational Medicine、PNAS、ATVB、Atherosclerosis等国际顶尖期刊和心血管领域专业杂志发表多篇学术论文,研究内容多次被国内外专业媒体如Science Daily,BioWorld等关注和报道。累积发表论文40余篇,影响因子>300分,论文引用1000余次。曾主持美国心脏协会Scientist Development Grant一项,已完成国家自然科学基金青年项目一项,现主持国家自然科学基金面上项目一项。荣获国际花生四烯酸大会青年学者奖和美国心脏协会杰出研究奖。长期担任Frontiers in Pharmacology、Journal of Pharmacological Reports期刊编委,及其它多个SCI杂志审稿人。曾任PPAR Research期刊客座主编。中国生理学会整合生理学专业委员会委员。
在研项目:
1.国家自然科学基金面上项目:巨噬细胞COX-2/mPGES-1/PGE2/EP4通路在急性心肌梗死中的作用,2017.1-2020.12, 57万元,项目负责人
研究领域
前列腺素及生物节律在慢性心血管及代谢性疾病中的作用。致力于利用细胞生物学和分子生物学手段,结合基因敲除和转基因动物模型及临床研究,揭示高血压等慢性心血管及代谢性疾病的发病机理并将研究成果向临床转化。
近期论文
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1.Lihong Chen,Guangrui Yang, Jiayang Zhang,Baoyin Ren,Soonyew Tang,Xuanwen Li,Garret A. FitzGerald. Time dependent hypotensive effect of aspirin in mice. Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2819-2826. doi: 10.1161/ATVBAHA.118.311296.
2.Jing Wang,Min Liu,Xiaoyan Zhang,Guangrui Yang,Lihong Chen*. Physiological and pathophysiological implications of PGE2 and the PGE2 synthases in the kidney. Prostaglandins Other Lipid Mediat. 2018 Jan;134:1-6.
3.Guangrui Yang and Lihong Chen*. An update of microsomal prostaglandin E synthase (mPGES)-1 and PGE2 receptors in cardiovascular health and diseases. Oxid Med Cell Longev. 2016; 2016:5249086.
4.Guangrui Yang,Lihong Chen (co-first),Gregory R. Grant Georgios Paschos,Wen-Liang Song, Erik S. Musiek,Vivian Lee,Sarah C. McLoughlin,Tilo Grosser,George Cotsarelis and Garret A. FitzGerald. Timed expression of Bmal1 influences aging and survival. Science Translational Medicine. Sci Transl Med. 2016 Feb 3;8(324):324ra16.
5.Lihong Chen,Guangrui Yang,James Monslow,Leslie Todd,David P. Cormode,Jun Tang,Gregory R. Grant,Jonathan H. DeLonge,Soon Yew Tang,John A. Lawson,Ellen Pure,and Garret A. FitzGerald. Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice. Proc Natl Acad Sci. 2014,111(18): 6828-6833
6.Lihong Chen,Guangrui Yang,Xiufeng Xu,Gregory Grant,John A. Lawson,Mohammad Bohlooly-Y and Garret A. FitzGerald. Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1. Circulation. 2013,127(2): 233-243.
7.Lihong Chen,Yifei Miao,Yahua Zhang,Dou Dou,Limei Liu,Xiaoyu Tian,Guangrui Yang,Dan Pu,Xiaoyan Zhang,Jihong Kang,Yuansheng Gao,Shiqiang Wang,Matthew D. Breyer,Nanping Wang,Yi Zhu,Yu Huang,Richard M. Breyer and Youfei Guan. Inactivation of the E-prostanoid 3 receptor attenuates the angiotensin II pressor pesponse via decreasing arterial contractility. Arterioscler Thromb Vasc Biol. 2012,32(12): 3024-3032.
8.Lihong Chen,Guangrui Yang,Xiaoyan Zhang,Jing Wu,Qing Gu,Mingfen Wei,Jichun Yang,Yi Zhu,Nanping Wang and Youfei Guan. Induction of MIF expression by oxidized LDL via activation of NF-κB in vascular smooth muscle cells. Atherosclerosis. 2009, 207(2): 428-433.