Wang, Jun - The University of Arizona

个人简介

BS, Chemistry, Wuhan University (China), 2003 MS, Chemistry, National University of Singapore, 2006 PhD, Chemistry, University of Pennsylvania, 2010

研究领域

Research in the Wang Laboratory is directed towards drug discovery targeting drug-resistant viruses, and elucidating the mechanism of drug resistance. We are exploring both small molecule- and miniprotein-based therapeutics to target either viral proteins or host factors. Techniques implemented in the Wang laboratory include but not limited to structure-based drug design, high-throughput screening, medicinal chemistry, electrophysiology, peptide chemistry, biophysics and virology. We are a diverse group and researchers in the Wang Lab have opportunity to explore all aspects of preclinical drug discovery in the same lab starting from molecular-level design to in vivo animal model studies. Project 1: Antiviral Drug Discovery and Mechanistic Studies of Drug Resistance Project 2: Structural Biology and Drug Discovery Targeting Ion Channels Project 3: Miniprotein-based theapeutics

近期论文

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Thomaston JL, Polizzi NF, Konstantinidi A, Wang J, Kolocouris A,* DeGrado WF.* (2018) Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters. J. Am. Chem. Soc. ASAP. PubMed Zhang, J., Hu, Y.M., Musharrafieh, R., Yin, H., Wang, J.* (2018) Focusing on the influenza polymerase complex: recent progress in drug discovery and assay development. Curr. Med. Chem. ASAP. PubMed Zhao X, Li R, Zhou Y, Xiao M, Ma C, Yang Z, Zeng S, Du Q, Yang C, Jiang H, Hu Y, Wang K, Mok CKP, Sun P, Dong J, Cui W, Wang J, Tu Y, Yang Z, Hu W.* (2018) Discovery of highly potent pinanamine-based inhibitors against amantadine- and oseltamivir-resistant influenza A viruses. J. Med. Chem. 2018, 61, 5187-5198. PubMed Mandour YM, Breitinger U, Ma C, Wang J, Boeckler FM, Breitinger HG, Zlotos DP. (2018) Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7. Drug Des. Devel. Ther. 12, 1019-1031. PubMed Zhang, J., Hu, Y.M., Foley, C., Wang, Y.X., Musharrafieh, R., Xu, S.T., Zhang, Y.T., Ma, C.L., Hulme, C., Wang, J.* (2018) Exploring Ugi-azide four-component reaction products for broad-spectrum influenza antivirals with a high genetic barrier to drug resistance. Sci. Rep. 8, 4653. PubMed Musharrafieh, R., Ma, C.L., Wang, J.* (2018) Profiling the in vitro drug-resistance mechanism of influenza A viruses towards the AM2-S31N proton channel blockers. Antiviral Res. 153, 10-22. PubMed Drakopoulos, A., Tzitzoglaki, C., McGuire, K., Hoffman, A., Konstantinidi, A., Kolokouris, D., Ma, C.L., Freudenberger, K., Hutterer, J., Gauglitz, G., Wang, J., Schmidtke, M., Busath, D., Kolocouris, A.* (2018) Unraveling the binding, proton blockage, and inhibition of influenza M2 WT and S31N by rimantadine variants. ACS Med. Chem. Lett. 2018, 9, 198-203. PubMed Wang, Y. X., Hu, Y.M., Xu, S. T., Zhang, Y.T., Musharrafieh, R., Hau, R., Ma, C.L., Wang, J.* (2018) In vitro pharmacokinetic optimizations of AM2-S31N channel blockers led to the discovery of slow-binding inhibitors with potent antiviral activity against drug-resistant influenza A viruses. J. Med. Chem. 61, 1074-1085. PubMed Ma, C.L., Wang, J.* (2018) Functional studies reveal the similarities and differences between AM2 and BM2 proton channels from influenza viruses. Biochim. Biophys. Acta.-Biomembrane 1860, 272-280. PubMed Williams, J.K., Shcherbakov, A.A., Wang, J., Hong, M.* (2017) Protonation equilibria and pore-opening structure of the dual-histidine influenza B virus M2 transmembrane proton channel from solid-state NMR. J. Biol. Chem. 292, 17876-17884. PubMed Hu, Y.M., Zhang, J.T., Musharrafieh, R., Hau, R., Ma, C.L., Wang, J.* (2017) Chemical genomics approach leads to the identification of hesperadin, an aurora B kinase inhibitor, as a broad-spectrum influenza antiviral. Int. J. Mol. Sci. 18, E1929. PubMed Hu, Y.M., Zhang, J.T., Musharrafieh, R., Ma, C.L., Hau, R., Wang, J.* (2017) Discovery of dapivirine, a nonnucleoside HIV-1 reverse transcriptase inhibitor, as a broad-spectrum antiviral against both influenza A and B viruses. Antiviral Res. 145, 103-113. PubMed Barniol-Xicota M, Gazzarrini S, Torres E, Hu Y, Wang J, Naesens L, Moroni A, Vazquez S.* (2017) Slow but steady wins the race: dissimilarities among new dual inhibitors of the wild-type and the V27A mutatn M2 channels of influenza A virus. J Med Chem 60, 3727-3738. PubMed Hu, Y.M., Wang, Y.X., Fang, L., Ma, C.L., Wang, J.* (2017) Design and expeditious synthesis of organosilanes as potent antivirals targeting multidrug-resistant influenza A viruses. E J Med Chem 135, 70-76. PubMed Hu, Y.M., Sneyd, H., Dekant, R., Wang, J.* (2017) Influenza A virus nucleoprotein: a highly conserved multi-functional viral protein as a hot antiviral drug target. Curr Top Med Chem 17, 2271-2285. PubMed Li, F., Hu, Y.M., Wang, Y.X., Ma, C.L., Wang, J.* (2017) Expeditious Lead Optimization of Isoxazole-Containing Influenza A Virus M2-S31N Inhibitors Using the Suzuki–Miyaura Cross-Coupling Reaction. J Med Chem 60, 1580-1590. PubMed Drakopoulos, A., Tzitzoglaki, C., Ma, C.L., Freudenberger, K. M., Hoffmann, A., Hu, Y.M., Gauglitz, G., Schmidtke, M., Wang, J.,* Kolocouris, A.,* (2017) Affinity of rimantadine enantiomers against Influenza A/M2 protein Revisited ACS Med Chem Lett 8, 145-150. PubMed Hu Y, Musharrafieh R, Ma C, Zhang J, Smee DF, DeGrado WF, Wang J.* (2017) An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses. Antiviral Res 140, 45-54. PubMed Li, F., Ma, C.L., Hu, Y.M., Wang, Y.X., Wang, J.* (2016) Discovery of potent antivirals aganist amantadine-resistant influenza A viruses by targeting the M2-S31N proton channel ACS Infect Dis 2, 726-133. PubMed Ma, C.L., Li, F., Musharrafieh, R., Wang, J.*(2016) Discovery of cyclosporine A and its analogs as broad-spectrum anti-influenza drugs with a high in vitro genetic barrier to drug resistance. Antiviral Res 133, 62-72. PubMed Ma,C.L., Zhang, J.T., Wang, J.* (2016) Pharmacological Characterization of the Spectrum of Antiviral Activity and Genetic barrier of Drug Resistance of M2-S31N Channel Blockers. Mol Pharmacol mol.116.105346. PubMed