Han, Gang - University of Massachusetts Medical School - Department of Biochemistry and Molecular Pharmacology

个人简介

B.S. Nanjing University, Ph.D. University of Massachusetts-Amherst, Postdoctoral Fellow. The Molecule Foundry, Lawrence Berkeley Lab.

研究领域

My research focuses on developing both small and bright tools for biomedical applications, that is, designing synthetic/semi-synthetic nanomaterials with unique programmable physical properties for basic science and biomedical applications. These nanomaterials will be developed using a synergetic multidisciplinary approach, including synthetic chemistry, materials science, biochemistry, and cell biology. In particular, we are most interested in developing optically active nanomaterials for probing signal transduction pathways, single-molecule imaging, synthesizing functional nanoscale scaffolds for targeted and traceable delivery of small molecules to cells and organelles, as well as for accurately detecting biomarkers in early stage disease. Research Topics Synthesis, modification and application of upconversion nanoparticles (UCNPs) for biomedical applications Synthesis, modification and application of persistent luminescence nanoparticles (PLNPs) for biomedical applications Synthesis, modification and application of organic dyes for biomedical applications

近期论文

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Nhung Thi Nguyen#, Kai Huang#, Hongxiang Zeng, Ji Jing, Rui Wang, Joyce Chen, Zixian Huang, Xin Liu, Anjana Rao, Yun Huang*, Gang Han*, Yubin Zhou* Nano-optogenetic Immunoengineering: Photo-Tunable Remote Control of CAR T-cells. Nature Nanotechnology(2021). In Press Huang K, Li Z, Li Y, Yu N, Gao X, Huang L, Lim SF, Han G. Three-Dimensional Colloidal Controlled Growth of Core-Shell Heterostructured Persistent Luminescence Nanocrystals. Nano Lett. 2021 Jun 8. doi: 10.1021/acs.nanolett.0c04940.In press . Lian He, Peng Tan, Lei Zhu, Kai Huang, Nhung T Nguyen, Rui Wang, Lei Guo, Ling Li, Yuhan Yang, Zixian Huang, Yun Huang,* Gang Han,* Junfeng Wang,* Yubin Zhou* Circularly permuted LOV2 as a modular photoswitch for optogenetic engineering. Nat Chem Biol (2021). In press https://doi.org/10.1038/s41589-021-00792-9 He, L., Huang, Z., Huang, K., Chen, R., Nguyen, N. T., Wang, R., Cai, X., Huang, Z., Siwko, S., Walker, J. R., Han, G.,* Zhou, Y.,* Jing, J.* Optogenetic Control of Non‐Apoptotic Cell Death. Adv. Sci. 2021, 2100424. Li, Z., Zhao, Y., Huang, K., Huang, L., Zhang, Y., Yang, H. and Han, G. Enhancing Rechargeable Persistent Luminescence via Organic Dye Sensitization. (2021), Angew. Chem. Int. Ed.. In press https://doi.org/10.1002/anie.202101492 (cover article) Huang, L., Le, T., Huang, K., Han, G. Enzymatic enhancing of triplet–triplet annihilation upconversion by breaking oxygen quenching for background-free biological sensing. Nat Commun 2021, 12, 1898. Chen, X., Li, Y., Huang, K., Huang, L., Tian, X., Dong, H., Kang, R., Hu, Y., Nie, J., Qiu, J., Han, G., Trap Energy Upconversion‐Like Near‐Infrared to Near‐Infrared Light Rejuvenateable Persistent Luminescence. Adv. Mater. 2021, 33, 2008722. (cover article) Huang, K., Dou, X., Zhang, Y., Gao, X., Lin, J., Qu, J., Li, Y., Huang, P., Han, G. Enhancing Light and X‐Ray Charging in Persistent Luminescence Nanocrystals for Orthogonal Afterglow Anti‐Counterfeiting. Adv. Funct. Mater. 2021, 2009920. Ling Huang, Le Zeng, Yongzhi Chen, Nuo Yu, Lei Wang, Kai Huang, Yang Zhao & Gang Han Long wavelength single photon like driven photolysis via triplet triplet annihilation Nature Communications, 05 January 2021, volume 12, Article number: 122 (2021) Zhanjun Li, Nuo Yu, Juanjuan Zhou, Yang Li, Yuanwei Zhang, Ling Huang, Kai Huang, Yang Zhao, Sharon Kelmar, Jinyi Yang, Gang Han Coloring Afterglow Nanoparticles for High-Contrast Time-Gating-Free Multiplex Luminescence Imaging Adv Mater 2020 Nov 3;Online ahead of print. Huang L, Wu W, Li Y, Huang K, Zeng L, Lin W, Han G. Highly Effective Near-Infrared Activating Triplet-Triplet Annihilation Upconversion for Photoredox Catalysis. J Am Chem Soc. 2020 142(43):18460-18470. Xiaohui Lin, Yang Li*, S. Saravanakumar, Qiang Tang, Shaoan Zhang, Xiuping Gao, Yihua Hu*, Kai Huang, Gang Han*. Sunlight-operable light converting smart windows for fertilizer-free plant growth enhancement. Nano Today. 2020;34:100918. Yekui Zhou, Yuanwei Zhang, Wenhai Lin, Samuel J. Kesseli, Ling Huang, Yang Zhao, Xikuang Yao, Kai Huang, Gang Han*. Wavelength-Selective Light-Controlled Stepwise Photolysis from Single Gold Nanoparticles. Advanced Healthcare Materials. 2020:2000321. Huiwang Lian, Yang Li*, Kaniyarakkal Sharafudeen, Weiren Zhao, Gopi R. Krishnan, Shaoan Zhang, Jianrong Qiu*, Kai Huang, Gang Han*.Highly Thermotolerant Metal Halide Perovskite Solids. Advanced Materials. 2020;32:2002495. (cover featured) Zhijia Wang, Ling Huang, Yuxin Yan, Ahmed M. El-Zohry, Antonio Toffoletti, Jianzhang Zhao*, Antonio Barbon*, Bernhard Dick*, Omar F. Mohammed*, Gang Han*. Elucidation of the Intersystem Crossing Mechanism in a Helical BODIPY for Low-Dose Photodynamic Therapy. Angewandte Chemie International Edition. 2020:doi:10.1002/anie.202005269. T Vaneckova, J Bezdekova, G Han, V Adam, M Vaculovicova Application of molecularly imprinted polymers as artificial receptors for imaging Acta Biomater. 2020 Jan 1;101:444-458. doi: 10.1016/j.actbio.2019.11.007. Epub 2019 Nov 6. W Lin, W Zhang, S Liu, Z Li, X Hu, Z Xie, C Duan, G Han Engineering pH-Responsive BODIPY Nanoparticles for Tumor Selective Multimodal Imaging and Phototherapy. ACS Appl Mater Interfaces. 2019 Nov 27;11(47):43928-43935. doi: 10.1021/acsami.9b16403. Epub 2019 Nov 13. M Chang, M Wang, M Shu, Y Zhao, B Ding, S Huang, Z Hou, G Han, J Lin Enhanced photoconversion performance of NdVO4/Au nanocrystals for photothermal/photoacoustic imaging guided and near infrared light-triggered anticancer phototherapy. Acta Biomater. 2019 Nov;99:295-306. doi: 10.1016/j.actbio.2019.08.026. Epub 2019 Aug 19. Xiaojing Dou, Yang Li, Tereza Vaněčková, Ru Kang, Yihua Hu, Hongli Wen, Xiuping Gao, Shaoan Zhang, Markéta Vaculovičová, Gang Han Versatile persistent luminescent oxycarbonates: Morphology evolution from nanorods through bamboo-like nanorods to nanoparticles. Journa of Luminescence. 2019; 215:116635. doi.org/10.1016/j.jlumin.2019.116635 Yang Zhao, Jing Peng, Jinyi Yang, Enlong Zhang, Ling Huang, Hong Yang, Eugenia Kakadiaris, Jingjin Li, Bin Yan, Zhiqun Shang, Ning Jiang, Xuening Zhang, Gang Han, Yuanjie Niu Enhancing Prostate‐Cancer‐Specific MRI by Genetic Amplified Nanoparticle Tumor Homing. Adv Mater. 2019 Jul;31(30):e1900928. doi: 10.1002/adma.201900928. Epub 2019 Jun 11.