Chen, Shuibing - Weill Cornell Medical College

个人简介

Kilts Family Associate Professor of Surgery, Surgery , Weill Cornell Medical College 2019 - Associate Professor of Chemical Biology in Surgery, Surgery , Weill Cornell Medical College 2017 - Associate Professor of Chemical Biology in Biochemistry, Biochemistry , Weill Cornell Medical College 2017 - Assistant Professor of Chemical Biology in Surgery, Surgery , Weill Cornell Medical College 2011 - 2017 Assistant Professor of Chemical Biology in Biochemistry, Biochemistry , Weill Cornell Medical College 2011 - 2017 Education and Training B.S., Tsinghua University (China) 99 Ph.D., Kellogg School of Science and Technology, The Scripps Research Institute 2002 - 2006 M.S., Tsinghua University (China) 2002

研究领域

The major research interest in the Chen Laboratory is to manipulate stem cell fate using chemical and biological approaches and to generate functional tissues and organs that can be used for translational research. Our current main focus is on human pluripotent stem cells (PSCs), including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs). We combine our knowledge of stem cell biology, developmental biology, chemical biology, medicine chemistry and tissue engineering to derive functional cells, tissues and organs from human pluripotent stem cells. Our long-term goal is to apply patient specific PSC-derived tissues or organs for replacement therapy and build up “disease in a dish” platforms for drug discovery.

近期论文

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A human embryonic stem cell reporter line for monitoring chemical-induced cardiotoxicity. Cardiovascular Research. 2020 Academic Article CLIC4 regulates late endosomal trafficking and matrix degradation activity of MMP14 at focal adhesions in RPE cells. Scientific Reports. 2019 Academic Article Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells. Nature Communications. 2019 Academic Article Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-β. Cell Chemical Biology. 2019 Academic Article Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. Neuron. 2019 Academic Article Author Correction: A recellularized human colon model identifies cancer driver genes (Nature Biotechnology, (2016), 34, 8, (845-851), 10.1038/nbt.3586). Nature Biotechnology. 2019 Article Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation. Nature Genetics. 2019 Academic Article Discovery of a drug candidate for GLIS3-associated diabetes. Nature Communications. 2018 Academic Article Male germ cells support long-term propagation of Zika virus. Nature Communications. 2018 Academic Article PRMT5-mediated regulation of developmental myelination. Nature Communications. 2018 Academic Article Derivation and characterization of a UCP1 reporter human ES cell line. Stem Cell Research. 2018 Academic Article ROCKII inhibition promotes the maturation of human pancreatic beta-like cells. Nature Communications. 2017 Academic Article A Modular Platform for Differentiation of Human PSCs into All Major Ectodermal Lineages. Cell Stem Cell. 2017 Academic Article An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis. Cell Reports. 2017 Academic Article Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing. Nature Medicine. 2017 Academic Article Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E. Cell Reports. 2017 Academic Article Efficient generation of cardiac purkinje-like cells from embryonic stem cells by activating cAMP signaling. Current protocols in stem cell biology. 2017 Academic Article Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells. Scientific Reports. 2017 Academic Article High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain. Cell Stem Cell. 2017 Academic Article Multifunctional in vivo imaging of pancreatic islets during diabetes development. Journal of Cell Science. 2016 Academic Article Discovery of a Small-Molecule BMP Sensitizer for Human Embryonic Stem Cell Differentiation. Cell Reports. 2016 Academic Article Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease. Nature. 2016 Academic Article A recellularized human colon model identifies cancer driver genes. Nature Biotechnology. 2016 Academic Article Dynamic self-organization of microwell-aggregated cellular mixtures. Soft Matter. 2016 Academic Article Modeling cystic fibrosis using pluripotent stem cell-derived human pancreatic ductal epithelial cells. Stem Cells Translational Medicine. 2016 Academic Article An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery. Cell Stem Cell. 2015 Academic Article Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell. 2015 Academic Article Efficient Generation of Cardiac Purkinje Cells from ESCs by Activating cAMP Signaling. Stem Cell Reports. 2015 Academic Article