Evans, Todd R. - Weill Cornell Medicine - Developmental Biology in Surgery

个人简介

Ph.D., Columbia University 1987 B.A., Northwestern University 1982

研究领域

From Stem Cells to Organs toward Regenerative Medicine During embryogenesis, molecular networks direct with temporal and spatial precision the specification of stem and progenitor cell populations, the differentiation of specific cell lineages and the morphogenesis of unique and complex organs. These same pathways continue to be used throughout life to maintain organ homeostasis, and disruptions in the various components cause human diseases. As an example, GATA transcription factors regulate development and function of the hematopoietic, cardiovascular, and gut-derived organ systems, and alterations in their activities are responsible for a variety of human syndromes and diseases. We are developing novel animal and stem cell models to manipulate components of GATA and other key regulatory pathways, and to define specificity for component functions. Having first "built" organs, we believe these molecular pathways can be reemployed to enhance regeneration of injured or diseased organs. A major goal of this work is to define potential targets for treating debilitating human diseases including cancer, heart disease, liver disease, diabetes, and asthma.

近期论文

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Pandey, S., Banks, K.M., Kumar, R., Kuo, A., Wen, D., Hla, T, and Evans, T. (2020). Sphingosine Kinases Protect Murine ESCs from Sphingosine-induced Cell Cycle Arrest. Stem Cells. In Press. Lan, Y., Pan, H., Li, C., Banks, K.M., Sam, J., Ding, B., Elemento, O., Goll, M. and Evans, T. TETs Regulate Proepicardial Cell Migration through Extracellular Matrix Organization during Zebrafish Cardiogenesis. (2019). Cell Reports. 26: 720-734. Fernando, T., Marullo, R., Pera, B., Phillip, J., Yang, S.N., Lundell-Smith, G., Torregroza, I., Ahn, H., Evans, T., Györffy, B., Prive, G.G., Hirano, M., Melnick, A., and Cerchietti, L. (2019). BCL6 Evolved to Enable Stress Tolerance in Vertebrates and is Broadly Required by Cancer Cells to Adapt to Stress. Cancer Discov. 9: 662-697. Li, H., Saucedo-Cuevas, L., Yuan, L., Ross, D., Johansen, A., Sands, D., Stanley, V., Guemez-Gamboa, A., Gregor, A., Evans, T., Chen, S., Tan, L., Molina, H., Sheets, N., Shiryaev, S.A., Terskikh, A.V., Gladfelter, A.S., Shresta, S., Xu, Z., Gleeson, J.G. (2019). Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. Neuron. 101: 1-10. Badieyan, Z.S. and Evans, T. (2019). Application of Chemically Modified mRNA in Cell Fate Conversion and Tissue Engineering. Stem Cells Trans. Med. 8: 833-843. Cook, B., Rafiq, R., Lee, H., Banks, K.M., El-Debs, M., Chiaravalli, J., Glickman, J.F., Das, B.C., Chen, S., Evans, T. (2019). Discovery of a Small Molecule Promoting Mouse and Human Osteoblast Differentiation via Activation of p38 MAPK-beta. Cell Chem. Biol. 26: 1-10. Li, Q.V., Dixon, G., Verma, N., Rosen, B.P., Gordillo, M., Xu, C., Wang, Q., Soh, C.-L., Yang, D., Crespo, M., Luo, R., Shukla, A., Xiang, Q., Dundar, F., Zumbo, P., Witkin, M., Koche, R., Betel, D., Chen, S., Massague, J., Garippa, R., Evans, T., Beer, M.A., Huangfu, D. (2019). Genome-Scale Screens Uncover JNK/JUN Signaling as a Key Barrier from Pluripotency to Human Endoderm Differentiation. Nature Genetics. 51: 999-1010. Kumar, R. and Evans, T. (2019). The Cytosine Deaminase AICDA Regulates FGF/ERK Signaling to Achieve the Naïve Pluripotent State During Reprogramming. Stem Cells. 37: 1003-1017. Jaffré, F., Miller, C.L., Schanzer, A., Evans, T., Roberts, A.E., Hahn, A., Kontaridis, M.I. (2019). Inducible Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome. Circulation. 140: 207-224. Tsai, S.-Y., Ghazizadeh, Z., Wang, H.-J., Amin, S., Ortega, F.A., Badieyan, Z.S., Hsu, Z.-T., Gordillo, M., Kumar, R., Christini, D.J., Evans*, T. and Chen*, S. (2019). A Human Embryonic Stem Cell Reporter Line for Monitoring Chemical-induced Cardiotoxicity. Cardiovasc. Res. cvz148, https://doi.org/10.1093/cvr/cvz148. Lee, H. and Evans, T. (2019). TMEM88 Inhibits Wnt Signaling by Promoting Wnt Signalosome Localization to Multivesicular Bodies. iScience. 19: 267-280. Lan, Y. and Evans, T. (2019). Epigenetic Regulation of Cardiac Development and Disease through DNA Methylation. J. Life Sciences. 1: 1-10. Tan, L., Lacko, L.A., Zhou, T., Tomoiaga, D., Hurtado, R., Zhang, T., Sevilla, A., Zhong, A., Mason, C., Noggle, S., Evans, T., Stuhlmann, H., Schwartz, R.E., Chen, S. (2019). Pre- and Peri-implantation Zika Virus Infection Impairs Fetal Development by Targeting Trophectoderm Cells. Nature Comm. 10: 4155. Doi: 10.1038/s41467-019-12063-2. Surya SL, Long MJC, Urul DA, Zhao Y, Mercer EJ, EIsaid IM, Evans T, Aye Y. (2018). Cardiovascular Small Heat Shock Protein HSPB7 Is a Kinetically Privileged Reactive Electrophilic Species (RES) Sensor. ACS Chem. Biol. 13: 1824-1831. www.ncbi.nlm.nih.gov/pubmed/29397684 Mercer EJ, Lin YF, Cohen-Gould L, Evans T. (2018). Hspb7 is a cardioprotective chaperone facilitating sarcomeric proteostasis. Dev. Biol. 435: 41-55. Ghazizadeh, Z., Fattahi, F., Mirzaei, M., Chae, S., Byun, K., Tabar, M.S., Ahmad, S.T., Mirshahvaladi, S., Shabani, P., Fonoudi, H., Baharvand, H., Aghdami, N., Evans, T., Lee, B., Salekdeh, G.H. (2018). Prospective Isolation of ISL1+ Cardiac Progenitors from human ESCs for Myocardial Infarction Therapy. Stem Cell Reports. 10: 848-859. Amin, S., Cook, B., Zhou, T., Ghazizadeh, Z., Lis, R., Zhang, T., Khalaj, M., Crespo, M., Perera, M., Xiang, J.Z., Zhu, Z., Tomishima, M., Evans, T., Huangfu, D., and Chen, S. (2018). Discovery of a Drug Candidate for GLIS3-Associated Diabetes. Nature Comm.9: 2681. Zhou, T., Kim, T.W., Chong, C.N., Tan, L., Amin, S., Badieyan, Z., Mukherjee, S., Ghazizadeh, Z.,Zeng, H., Guo, M., Crespo, M.,Zhang, T., Kenyon, R., Robinson, C.L.,Apostolou, E.,Wang, H., Xiang, J.Z., Evans, T., Studer, L., Chen. S. (2018). A hPSC-based Platform to Discover Gene-Environment Interactions that Impact Human β -Cell and Dopamine Neuron Survival. Nature Comm.9: 4815. Guo M, Zhang T, Dong X, Xiang JZ, Lei M, Evans T, Graumann J, Chen S. (2017). Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E .Cell Reports 19: 1512-1521. www.ncbi.nlm.nih.gov/pubmed/28538172 Shi ZD, Lee K, Yang D, Amin S, Verma N, Li QV, Zhu Z, Soh CL, Kumar R, Evans T, Chen S, Huangfu D. (2017). Genome Editing in hPSCs Reveals GATA6 Haploinsufficiency and a Genetic Interaction with GATA4 in Human Pancreatic Development. Cell Stem Cell 20: 675-688. www.ncbi.nlm.nih.gov/pubmed/28196600 Tsai SY, Chen S, Evans T. Efficient Generation of Cardiac Purkinje-like Cells from Embryonic Stem Cells by Activating cAMP Signaling. Curr. Protoc. Stem Cell Biol. 40: 1F.16.1-1F.16.13 www.ncbi.nlm.nih.gov/pubmed/28152183