tenOever, Benjamin R - Icahn School of Medicine at Mount Sinai

个人简介

Ben completed his postdoctoral formation in Molecular Biology from Harvard University in 2007 after receiving his PhD in Medicine from McGill University in 2004. This training was subsequently applied to the study of host and pathogen interactions, with a focus on the molecular biology of virus infection. In August of 2007, Dr. tenOever joined the Icahn School of Medicine at Mount Sinai as an Assistant Professor of Microbiology. He is now a Fishberg Professor of Medicine, an Icahn Professor of Microbiology, and the Director of the Virus Engineering Center for Therapeutic and Research (VECToR) at Mount Sinai. He is a 2008 Pew Scholar, a recipient of the 2009 Presidential Award in Science and Engineering, a 2010 recipient of the American Society of Microbiology Young Investigator Award, a 2011 Cozzarelli Prize winner, and he received the Burroughs Wellcome Award for Investigators in the Pathogenesis of Infectious Disease. From 2012 to 2013, he was honored with Outstanding Young Investigator Awards from the American Society of Gene and Cell Therapy and the American Society of Virology. He was also named a finalist for the Vilcek Award for creative promise and served as a US Ambassador of Science in France as a Distinguished Chair of the Fulbright Commission in 2015/2016. Most recently he was honored with a 2017/2018 Innovator Prize by the Pew Charitable Trust.

研究领域

The tenOever lab is interested in the way cells have evolved to defend themselves against virus infection and using this information to generate novel antiviral therapies and biological tools. Our primary interests at this time are to learn more about the biology of SARS-CoV-2 and test FDA-approved drugs in various model systems to find therapeutics for COVID-19 that could be used immediately.

近期论文

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Blanco-Melo D, Nilsson-Payant B, Liu W, Uhl S, Hoagland D, Moeller R, Jordan TX, Oishi K, Panis M, Sachs D, Wang TT, Schwartz RE, Lim JK, Albrecht R, and tenOever BR. Imbalanceed host response to SARS-CoV-2 drives development COVID-19. Cell 2020, In press. Blanco-Melo D, Bilsson-Payan B, Uhl S, Escudero-Perez B, Olschewski S, Thibault P, Panis M, Rosenthal M, Munoz-Fontela C, Lee B, tenOever BR. Engineering An inability to maintain the ribonucleoprotein genomic structure is responsible for hos detection of negative-sense RNA viruses. bioRxiv 2020, bioRxiv 2020.03.12.989319; doi: https://doi.org/10.1101/2020.03.12.989319. Suryawanshi H, Morozov P, Muthukumar T, tenOever BR, Yamaji M, Williams Z, Tuschl T. Cell-Type-Specific Expression of Renin-Angiotensin-System Components in the Human Body and Its Relevance to SARS-CoV-2 Infection. bioRxiv 2020.04.11.034603; doi: https://doi.org/10.1101/2020.04.11.034603. Moeller R, Oishi K, tenOever BR. Engineering an RNA-based tissue-specific platform for genetic editing through use of a miRNA-enabled Cas12a. bioRxiv 2020, bioRxiv 2020.03.04.977363; doi: https://doi.org/10.1101/2020.03.04.977363. McCune BT, Lanahan MR, tenOever BR, and Pfeiffer JK, Rapid dissemination and monopolization of viral populations in mice revealed using a panel of barcoded viruses. J Virol. 2020, 94 (2); 1590-19 doi: 10.1128/JVI.01590-19. tenOever BR, Synthetic Virology: Building Viruses to Better Understand Them. Cold Spring Harb. 2019 Dec 30. pii: a038703. doi: 10.1101/cshperspect.a038703. Munoz-Moreno R, Martinez-Romero C, Blanco-Melo D, Forst CV, Nachbagauer R, Benitez AA, Mena I, Aslam S, Balasubramaniam V, Lee I, Panis M, Ayllon J, Sachs D, Park M, Krammer F, tenOever BR, and Garcia-Sastre A. Viral fitness landscapes in diverse host species reveal multiple evolutionary lines for the NS1 gene of influenza A viruses. Cell Reports. 2019. 29(12), 3997-4009. Eggenberger J, Blanco-Melo D, Panis M, Brennand KJ, tenOever BR. Type I interferon response impairs differentiation potential of pluripotent stem cells. PNAS 2019. https://doi.org/10.1073/pnas.1812449116. Aguado L, Jordan T, Hsieh E, Blanco-Melo D, Heard J, Panis M, Vignuzzi M, tenOever BR. Homologous recombination is an intrinsic defense against antiviral RNA interference. PNAS 2018. doi: 10.1073/pnas.1810229115. Moeller R, Schwarz TM, Noriega VM, Panis M, Sachs D, Tortorella D, tenOever BR. miRNA-mediated targeting of human cytomegalovirus reveals biological host and viral targets of IE2. PNAS. 2018 doi: 10.1073/pnas.1719036115 Han J, Perez JT, Chen C, Li Y, Benitez A, Kandasamy M, Lee Y, Andrade J, tenOever B, Manicassamy B. Genome-wide CRISPR/Cas9 screen identifies host factors essential for influenza A virus replication. Cell Reports. 2018 doi: 10.1016/j.celrep2018.03.045 Aguado LC, tenOever BR. RNase III Nucleaes and the Evolution of Antiviral Systems. Bioessays. 2018 Feb;40(2). doi: 10.1002/bies.201700173. Aguado LC, Schmid S, May J, Sabin LR, Panis M, Blanco-Melo D, Shim JV, Sachs D, Cherry S, Simon AE, Levraud JP, tenOever BR. RNase III nucleases from diverse kingdoms serve as antiviral effectors. Nature. 2017 Jul 6;547(7661):114-117. PMID 28658212 Aguado LC, tenOever BR. RNase III nucleases and the evolution of antiviral systems. Bioessays. 2017 Dec 21 doi: 10.1002/bies.20170173. PMID 29266287 Wohlbold TJ, Podolsky KA, Chromikova V, Kirkpatrick E, Falconieri V, Meade P, Amanat F, Tan J, tenOever BR, Tan GS, Subramaniam S, Palese P, Krammer F. Broadly protective murine monoclonal antibodies against influenza A virus target highly conserved neuraminidase epitopes. Nat Microbiol. 2017;10:1415. doi: 10.1038/s41564-017-0011-8. PMID: 28827718. Duehr J, Wohlbold TJ, Oestereich L, Chromikova V, Amanat F, Rajendran M, Gomez-Medina S, Mena I, tenOever BR, García-Sastre A, Basler CF, Munoz-Fontela C, Krammer F. Novel cross-reactive monoclonal antibodies against Ebolavirus glycoproteins show protection in a murine challenge model. J Virol. 2017. Jun 7. pii: JVI.00652-17 PMID: 28592526 tenOever BR. Questioning antiviral RNAi in mammals. Nat. Microbiology. 2017 Apr 25;2:17052 PMID: 28440277 Beaty SM, Park A, Won ST, Hong P, Lyons M, Vigant F, Freiberg AN, tenOever BR, Duprex WP, Lee B. Efficient and Robust Paramyxoviridae Reverse Genetics Systems. mSphere. 2017 Mar 29;2(2). pii: e00376-16. PMID: 28405630 Morales, L., Oliveros, JC., Fernandez-Delgado, R., tenOever, BR., Enjuanes, L. and Sola, I. Contribution of host and viral small non-coding RNAs to SARS-CoV lung pathology. Cell Host & Microbe 2017, Mar 8;21(3):344-355. PMID: 28216251 Aguado LC, tenOever BR. RNA virus building blocks – miRNAs not included. PLoS Pathogens. 2018 May 31;14 (5).