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研究领域

内质网形态发生和维持的分子机制及其生理功能的研究。

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1. Lipid interaction of the C terminus and association of the transmembrane segments facilitate atlastin-mediated homotypic endoplasmic reticulum fusion. Liu TY, Bian X, Sun S, Hu X, Klemm RW, Prinz WA, Rapoport TA, Hu J. Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):E2146-54. 2. Structures of the atlastin GTPase provide insight into homotypic fusion of endoplasmic reticulum membranes. Bian X, Klemm RW, Liu TY, Zhang M, Sun S, Sui X, Liu X, Rapoport TA, Hu J.Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):3976-81. 3. A class of dynamin-like GTPases involved in the generation of the tubular ER network. Hu J, Shibata Y, Zhu PP, Voss C, Rismanchi N, Prinz WA, Rapoport TA, Blackstone C. Cell. 2009 Aug 7;138(3):549-61. 4. Membrane proteins of the endoplasmic reticulum induce high curvature tubules. Hu J, Shibata Y, Voss C, Shemesh T, Li Z, Coughlin M, Kozlov MM, Rapoport TA, Prinz WA. Science. 2008 Feb 29;319(5867):1247-50.

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