陈勇 - 中国科学院大学 - 生命科学学院

个人简介

招生专业 071010-生物化学与分子生物学 086000-生物与医药招生方向表观遗传学的结构生物学研究表观遗传学的结构生物学研究教育背景 1999-09--2005-01 清华大学博士学位 1995-09--1999-07 清华大学学士学位工作简历 2012-08~现在, 上海生命科学研究院生化细胞所, 研究员 2005-05~2012-08,美国密歇根大学, 博士后教授课程 bio2000 分子生物学奖励信息（1）中国科学院优秀研究生导师奖, 院级, 2016 科研项目（ 1 ）组蛋白甲基转移酶SET1家族蛋白活性调控的结构基础, 主持, 国家级, 2015-01--2018-12 （ 2 ）蛋白质复合物调控染色体结构的分子机理, 主持, 国家级, 2013-01--2017-12 （ 3 ）端粒酶复合体与染色质重塑复合物的结构与功能研究, 主持, 部委级, 2014-01--2018-12 （ 4 ）非编码RNA和MLL复合物协同作用调控基因转录的分子机制, 主持, 省级, 2014-09--2017-08 （ 5 ） SWI/SNF家族染色质重塑蛋白复合物的结构和功能研究, 主持, 国家级, 2017-01--2020-12 （ 6 ） SET1家族复合物在胚胎干细胞命运决定中发挥功能的分子机制, 主持, 国家级, 2020-01--2023-12

近期论文

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（1） The structural basis for specific recognition of H3K14 acetylation by Sth1 in the RSC chromatin remodeling complex, Structure, 2020, 通讯作者（2） The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex, Nucleic Acids Research, 2019, 通讯作者（3） Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast, Nucleic Acids Research, 2019, 通讯作者（4） The inner nuclear membrane protein Bqt4 in fission yeast contains a DNA-binding domain essential for telomere association with the nuclear envelope, Structure, 2019, 通讯作者（5） The structural biology of the shelterin complex, Biological Chemistry, 2019, 通讯作者（6） CRISPR-CAS9-mediated base editing screening in mice identifies DND1 amino acids that are critical for primordial germ cell development, Nature Cell biology, 2018, 通讯作者（7） Structural basis for DAXX interaction with ATRX, Protein & Cell, 2017, 通讯作者（8） Structural and functional analysis of the mammalian TIN2-TPP1-TRF2 telomeric complex, Cell Research, 2017, 通讯作者（9） Structure of the fission yeast S. pombe telomeric Poz1-Tpz1-Rap1 complex, Cell Research, 2017, 通讯作者（10） Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction, J.Med. Chem., 2017, 第 6 作者（11） NBS1 phosphorylation status dictates repair choice of dysfunctional telomeres, Molecular Cell, 2017, 第 4 作者（12） Structural basis for activity regulation of MLL family methyltransferases, Nature, 2016, 通讯作者（13） TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions, Nature Communication, 2016, 第 2 作者（14） Dimerization of SLX4 contributes to functioning of the SLX4-nuclease complex, Nucleic Acids Research, 2016, 第 6 作者（15） Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex, J. Med. Chem, 2016, 第 5 作者（16） Essential role of lncRNA binding for WDR5 maintenance of active chromatin and embryonic stem cell pluripotency, Elife, 2014, 第 3 作者（17） Structure of the SPRY domain of Ash2L and its interactions with RbBP5 and DPY30, Cell research, 2012, 第 1 作者（18） Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding, EMBO Report, 2011, 第 1 作者（19） A Conserved Motif within RAP1 Plays Diversified Roles in Telomere Protection and Regulation in Different Organisms, Nat. Struct. Mol. Biol., 2011, 第 1 作者（20） An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain, PLoS One, 2010, 第 1 作者（21） Structural basis of selective ubiquitination of TRF1 bys SCFFBX4, Dev Cell, 2010, 第 4 作者（22） A Shared Docking Motif in TRF1 and TRF2 Used for Differential Recruitment of Telomeric Proteins, Science, 2008, 第 1 作者（23） Full-length Escherichia coli SecA dimerizes in a closed conformation in solution as determined by cryo-electron microscopy., J. Biol. Chem., 2008, 第 1 作者（24） Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins, Proc. Natl. Acad. Sci. U S A., 2008, 第 3 作者（25） The active ring-like structure of SecA revealed by electron crystallography: conformational change upon interaction with SecB, Journal of Structural Biology, 2007, 第 1 作者（26） Crystal structure of human histone lysine-specific demethylase 1 (LSD1), Proc. Natl. Acad. Sci. U S A., 2006, 第 1 作者（27） Escherichia coli CorA periplasmic domain functions as a homotetramer to bind substrate, Journal of Biological Chemistry, 2006, 第 1 作者（28） The identification of a new actin-binding region in p57, Cell research, 2006, 第 2 作者（29） Ring-like pore structures of SecA: implication for bacterial protein-conducting channels, Proc. Natl. Acad. Sci. U S A., 2003, 第 1 作者（30） Two-dimensional crystallization of a small heat shock protein HSP16.3 on lipid layer, Biochem. Biophys. Res. Commun., 2003, 第 1 作者（31） DnaK and DnaJ facilitated the folding process and reduced inclusion body formation of magnesium transporter CorA overexpressed in Escherichia coli, Protein Expr. Purif., 2003, 第 1 作者