个人简介

B.Sc., Cornell University Ph.D., Brown University Research Associate, The James Franck Institute, The University of Chicago

研究领域

Physical and Theoretical Chemistry

My research is in theoretical biophysics and physical chemistry. Our interdisciplinary research program utilizes and develops a range of novel and powerful techniques that spans fields from modern physical chemistry, biophysics, and soft condensed matter physics. The driving force in the advances of our research program is our close collaboration with experiments groups. A number of areas of current interest to us include (i) ion atmosphere around DNA, RNA, and riboswitch; (ii) stochastic process of rare events in biological systems.

近期论文

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Haran, T. E.; Cohen, I.; Spasic, A.; Yang, K.; Mohanty, U. “Dynamics of Curved DNA Molecules: Prediction and Experiment.” J. Am. Chem. Soc. 125, 11160-11161 (2003). Haran, T. E.; Cohen, I.; Spasic, A.; Yang, K.; Mohanty, U. “Characteristics of Migration Patterns of DNA Oligomers in Gels and its Relationship to the Question of Intrinsic DNA Bending.” J. Am. Chem. Soc. 126, 2372-2377 (2004). Mohanty, U.; “Fragility Metrics in Glass-Forming Liquids.” Adv. Chem. Phys. 129, 73-105 (2004). Spasic. A.; Yang, K.; Mohanty, U. “Towards a Model for the Mobility of Circularly Permuted DNA Fragments in Gel.” Ed. Somasundaran, P.; Markovic, B., American Chemical Society Symposium Series Vol 69, #878, 149-166 (2004). Spasic, A.; Hess, G.; Becker, K. A.; Hansen, M.; Bleil, R.; Mohanty, U. “Asymmetric Charge Neutralization of DNA.” Ed. Stellwagen, N. C. and Mohanty, U., American Chemical Society Symposium Series #884, Chapter 6, 133-143 (2004). Mohanty, U.; Spasic, A.; Kim, H. D.; Chu, S. “Ion Atmosphere of Three-Way Junction Nucleic Acid.” J. Phys. Chem. B. 109, 21267-21272 (2005). Schultes, E.; Spasic, A.; Mohanty, U.; Bartel, D. “Collapse of Randomly Generated RNA Sequences.” Nature and Structural Biology 12, 1130-1136 (2005). Taubes, C. H.; Mohanty, U.; Chu, S. “Ion Atmosphere Around Nucleic Acid.” J. Phys. Chem. B. 109, 21267-21272 (2005). Casalini, R.; Mohanty, U.; Roland, C. M. “Thermodynamic Interpretation of the Scaling Dynamics of Supercooled Liquids.” J. Chem. Phys. 125, 014505-014513(2006). Mohanty, U.; Spasic, A. “Counterion Condensation in Nucleic acid.” Adv. Chem. Phys. Volume 139, 139-176 (2008). Mohanty, U. “Temperature Dependence of Relaxation Time in Adam-Gibbs Model of Glass-Forming Liquids: Fluctuation Effects.” Ed. Co, A.; Leal, L. G.; Colby, R. H.; Giacomin, A. J., America Institute of Physics Proceedings of XVth International Congress on Rheology 1027, 1324-1326 (2008). Spasic, A.; Sanyasi, S.; Mohanty, U.; Chu, S. “Polyelectrolyte Behavior and Kinetics of aa-tRNA on the Ribosome.” J. Phys. Chem. B 125, 014505-014513 (2008). Guo, Z.; Taubes, C. H.; Maher, J; Mohanty, U. “DNA on a Tube: Electrostatic Contribution to DNA Stiffness.” J. Phys. Chem. B 2008, 112, 16163-16169 (2008) Haran, T.; Mohanty, U. “The Unique Structure of A-tracts and Intrinsic DNA Bending.” Q. Rev. Biophys. 42, 41-81 (2009). Roberts, M.; Mohanty, U.; Redfield, A. “Phospholipids Reorientation at the Lipid/Water Interface Measured by High Resolution 31P NMR Field Cycling Spectroscopy.” Biophys. J. 97, 132-141 (2009). Guo, Z.; Mohanty, U.; Nohere, J.; Sawyer, T.; Sherman, W.; Krilov, G. “Probing the Alpha-Helical Stability of p53 Peptides: Molecular Dynamics Simulations and Analysis.” Chem. Biol. Drug. Design. 75, 348-359 (2010). Guo, Z.; Gibson, M.; Sanyasi, S.; Chu, S.; Mohanty, U. “Role of Large Thermal Fluctuations and Magnesium Ions in t-RNA Selectivity of the Ribosome.” Proc. Nat. Acad. USA. 108, 3947-51 (2011). Hayes, R. L.; Noel, J. K.; Mohanty, U.; Whitford, P.; Hennelly, S.; Onuchic, J. N.; Sanbonmatsu, K. “Magnesium Fluctuations Modulate RNA Dynamics in SAM-I Riboswitch.” J. Am. Chem. Soc. 134, 12043-12053 (2012). Guo, Z.; Streu, K.; Krilov, G.; Mohanty, U. “Probing the Origin of Single and Double Stapled p53 Analogs Bound to MDM2.” Chem. Biol. Drug. Design (≈19 journal pages, in press). Hayes, R. L.; Noel, J. K.; Whitford, P.; Mohanty, U,; Sanbonmatsu, K.; Onuchic, J. N. “Reduced Model Captures Mg2+-RNA Interaction Free Energy of Riboswitches.” Biophysical J. (≈18 journal pages, in press).