研究领域
细胞内的蛋白质合成后要被运输到不同的区域发挥作用，神经元是一种特化的细胞，除了胞体它还具有长的轴突和树突，因此蛋白质在细胞内的长距离运输就更为重要。我们实验室对两部分的研究内容感兴趣，一方面是受体和离子通道运输的调控机制及在感觉传递中的生理病理意义，另一方面是蛋白质运输的轨道微管翻译后修饰的调控及对神经元发育和神经系统疾病的影响。
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1. Li L, Wei D, Wang Q, Pan J, Liu R, Zhang X and Bao L. (2012) MEC-17 deficiency leads to reduced α-tubulin acetylation and impaired migration of cortical neurons. J. Neurosci., 32: 12673-12683.
2. Chen XQ, Wang B, Wu C, Pan J, Yuan B, Su YY, Jiang XY, Zhang X and Bao L. (2012) Endosome-mediated retrograde axonal transport of P2X3 receptor signals in primary sensory neurons. Cell Res., 22: 677-696.
3. He SQ, Zhang ZN, Guan JS, Liu HR, Zhao B, Wang HB, Li Q, Yang H, Luo J, Li ZY, Wang Q, Lu YJ, Bao L and Zhang X. (2011) Facilitation of μ-opioid receptor activity by preventing δ-opioid receptor-mediated codegradation. Neuron, 69: 120-131.
4. Li Q, Su YY, Wang H, Li L, Wang Q and Bao L. (2010) Transmembrane segments prevent surface expression of sodium channel Nav1.8 and promote calnexin-dependent channel degradation. J. Biol. Chem., 285: 32977-32987.
5. Liu C, Li Q, Su YY and Bao L (2010) Prostaglandin E2 promotes Nav1.8 trafficking via its intracellular RRR motif through the protein kinase A pathway. Traffic, 11: 405-417.
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