Mao, Hanbin - Kent State University - Department of Chemistry and Biochemistry

个人简介

2018 - now, Professor, Advanced Materials and Liquid Crystal Institute, Kent State University, Kent, OH 2015 - now, Professor, School of Biomedical Science, Kent State University, Kent, OH 2015 - now, Professor, Department of Chemistry and Biochemistry, Kent State University, Kent, OH 2011-2015, Associate Professor, Department of Chemistry and Biochemistry, Kent State University, Kent, OH 2005-2011, Assistant Professor, Department of Chemistry, Kent State University, Kent, OH 2003-2005, Postdoctoral Associate, Department of Chemistry, University of California , Berkeley , CA 1999-2003, Ph.D. in Chemistry, Department of Chemistry, Texas A&M University, College Station, TX 1997-1999, M.A in Chemistry, Boston University, Boston , MA 1995-1997, Assistant Researcher, Institute of Pharmacy, Zhejiang Academy of Medical Sciences, Zhejiang , China 1991-1995, B.S. in Medicinal Chemistry, Department of Pharmacy, West China University of Medical Sciences, Sichuan, China

研究领域

NUCLEIC ACID STRUCTURES Nucleic acids (DNA and RNA) are fundamental components of all forms of life. They function to store, transmit, and express genetic information. In these processes, DNA and RNA structures play central roles. Taking advantage of our optical tweezers, we have studied a variety of DNA and RNA structures to reveal their implications for life activities.

近期论文

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Amalgamation of DNAzyme and Nanozyme in a燙oronazyme Li Zuo, Kehao Ren, Xianing Guo, Pravin Pokhrel, Bishal Pokhrel, Mohammad Hossain, Chen Zhao-Xu, Hanbin Mao*, and Hao Shen*. Journal of the American Chemical Society, 2023, DOI = ja-2022-12367r (Accepted). Ensemble Force Spectroscopy of a G-quadruplex Cluster on a Single-molecule Platform Pravin Pokhrel�, Jiayi Wang�, Sangeetha Selvam, Sagun Jonchhe, Shankar Mandal, Hanbin Mao*. Biomacromolecules, 2022, 23, 11, 4795�4803. Mechanical Stability of DNA Corona Phase on Gold Nanospheres Pravin Pokhrel, Kehao Ren, Hao Shen, Hanbin Mao*. Langmuir, 2022, 38, 44, 13569�13576. Zeptoliter DNA Origami Reactor to Reveal Cosolute Effects on Nanoconfined G-Quadruplexes Shankar Pandey, Sagun Jonchhe, Shubham Mishra, Tomoko Emura, Hiroshi Sugiyama, Masayuki Endo, and Hanbin Mao*. Journal of Physical Chemistry Letters, 2022, 13, 37, 8692�8698. Ensemble Force Spectroscopy by Shear Forces Pravin Pokhrel, Changpeng Hu, Hanbin Mao*. Journal of Visualized Experiments, 2022, DOI:10.3791/63741. Short LNA-modified oligonucleotide probes as efficient disruptors of DNA G-quadruplexes Souroprobho Chowdhury, Jiayi Wang, Sabrina Pia Nuccio, Hanbin Mao*, Marco Di Antonio*. Nucleic Acids Research, Volume 50, Issue 13, 22 July 2022, Pages 7247-7259. Single-molecule displacement assay reveals strong binding of polyvalent dendrimer ligands to telomeric G-quadruplex Pravin Pokhrel, Shogo Sasaki, Changpeng Hu, Deepak Karna, Shankar Pandey, Yue Ma, Kazuo Nagasawa*, Hanbin Mao*. Analytical Biochemistry, 2022, 114693. Single-Molecule Mechanochemical Sensing Changpeng Hu, Rabia Tahir, Hanbin Mao. Accounts of Chemical Research, 2022, 55, 9, 1214-1225. Small molecules modulate liquid-to-solid transitions in phase-separated Tau condensates Sagun Jonchhe, Wei Pan, Pravin Pokhrel, Hanbin Mao. Angewandte Chemie International Edition, DOI: 10.1002/anie.202113156 Dissection of nanoconfinement and proximity effects on the binding events in DNA origami nanocavity Sagun Jonchhe, Shankar Pandey, Christian Beneze, Tomoko Emura, Hiroshi Sugiyama, Masayuki Endo, Hanbin Mao. Nucleic Acids Research, 2022, 50, 2, 697-703. Chirality transmission in macromolecular domains Shankar Pandey, Shankar Mandal, Mathias Bogetoft Danielsen, Asha Brown, Changpeng Hu, Niels Johan Christensen, Alina Vitaliyivna Kulakova, Shixi Song, Tom Brown, Knud J. Jensen, Jesper Wengel, Chenguang Lou, and Hanbin Mao. Nature Communications, 2022, 13, 76. Direct Measurement of Intermolecular Mechanical Force for Nonspecific Interactions between Small Molecules Shankar Pandey, Yuan Xiang, Dirk Friedrich, Yongsheng Leng, and Hanbin Mao*. The Journal of Physical Chemistry Letters, 2021, 12, 46, 11316-11322. Measurement of Single-Molecule Forces in Cholesterol and Cyclodextrin Host-Guest Complexes Shankar Pandey, Yuan Xiang, Dilanka V. D. Walpita Kankanamalage, Janarthanan Jayawickramarajah, Yongsheng Leng*, and Hanbin Mao*. The Journal of Physical Chemistry B, 2021, 125, 40, 11112-11121. DNA Origami Nanomechanics Jiahao Ji, Deepak Karna, and Hanbin Mao. Chemical Society Reviews, 2021,50, 11966-11978. Mechanical unfolding of ensemble biomolecular structures by shear force Changpeng Hu, Sagun Jonchhe, Pravin Pokhrel, Deepak Karna, Hanbin Mao. Chemical Science, 2021, 12, 10159-10164. Chemo-Mechanical Modulation of Cell Motions Using DNA Nanosprings Deepak Karna, Morgan Stilgenbauer, Sagun Jonchhe, Kazuya Ankai, Ibuki Kawamata, Yunxi Cui, Yao-Rong Zheng, Yuki Suzuki*, and Hanbin Mao*. Bioconjugate Chemistry, 2021, 2021, 32, 2, 311-317. Mechanochemical properties of DNA origami nanosprings revealed by force jumps in optical tweezers Deepak Karna, Wei Pan, Shankar Pandey, Yuki Suzuki, Hanbin Mao. Nanoscale, 2021, 2021, 13, 8425-8430. Cooperative hetero-ligands interaction with G-quadruplexes shows evidence of allosteric binding Shankar Pandey, Yuanyuan Li, Montwaun Young, Shankar Mandal, Laichun Lu, Jacob Shelley, Hanbin Mao. Biochemistry, 2020, 59, 37, 3438-3446. Ensemble sensing using single-molecule DNA copolymers Sagun Jonchhe, Saneetha Selvam, Deepak Karna, Shankar Mandal, Benjamin Wales-McGrath, Hanbin Mao. Analytical Chemistry, 2020, 92,19, 13126-13133. A poly(thymine)-melamine duplex for the assembly of DNA nanomaterials Qian Li, Jiemin Zhao, Longfei Liu, Sagun Jonchhe, Felix J. Rizzuto, Shankar Mandal, Huawei He, Sansen Wei, Hanadi F. Sleiman*, Hanbin Mao* & Chengde Mao*. Nature Materials, 2020, 19, 1012-1018.