Gao, Jianmin - Boston College - Department of Chemistry

个人简介

Education Ph.D. 07/2004 Chemistry, Stanford University, Stanford, CA B.S. 07/1999 Chemistry, University of Science and Technology of China Hefei, Anhui, P.R.China Professional Experience 07/2013-present Ass0ciate Professor of Chemistry, with Tenure Boston College, Chestnut Hill, MA 07/2007-06/2013 Assistant Professor of Chemistry Boston College, Chestnut Hill, MA 08/2004-07/2007 Postdoctoral Researcher with Professor Jeffery W. Kelly The Scripps Research Institute, La Jolla, CA 09/1999-07/2004 Ph.D. Thesis with Professor Eric T. Kool Stanford University, Stanford, CA 01/1998-06/1999 Undergraduate Reseacher with Professor Qing-Xiang Guo University of Science and Technology of China, Hefei China SELECTED HONORS AND AWARDS Boston College Graduate School Teaching/Mentoring Award (2020) Chinese-American Chemistry Professors Association (CAPA) Distinguished Faculty Award (2019) Smith Family Young Investigator Award, 2007

研究领域

The Gao lab works in the general areas of organic chemistry and chemical biology. Specifically, we are interested in understanding and ultimately gaining control over the functions of cell membranes. As a defining feature of a cell, the cell membrane hosts close to one third of the entire proteome and mediates numerous signaling pathways. Our lab uses organic synthesis to create novel peptides and peptidomimetics that functionally mimic natural membrane proteins, including channel formers and lipid-targeting proteins. Research activities as such allow us to elucidate new chemical principles of protein-membrane interactions. Synthetic molecules that are active on biomembranes may also serve as novel antibiotics and tumor imaging agents.

近期论文

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Sam Cambray and Jianmin Gao*, “Versatile Conjugation Chemistries of ortho-Boronyl Aryl Ketones and Aldehydes,” Acc. Chem. Res., 2018, 51, 2198-206. Kelly A. McCarthy, Michael A. Kelly, Kaicheng Li, Samantha Cambray, Azade Hosseini, Tim van Opijnen, and Jianmin Gao*, “Phage display of dynamic covalent binding motifs enables facile development of targeted antibiotics,” J. Am. Chem. Soc., 2018, 140, 6137-45. Anupam Bandyopadhyay,# Samantha Cambray,# and Jianmin Gao*, “Fast diazaborine formation of semicarbazide enables facile labeling of bacterial pathogens,” J. Am. Chem. Soc., 2017, 139, 871-8. Anupam Bandyopadhyay, Kelly A. McCarthy, Michael A. Kelly and Jianmin Gao*, “Targeting Bacteria via Iminoboronate Chemistry of Amine-Presenting Lipids,” Nat. Commun., 2015, DOI: 10.1038/ncomms7561.