个人简介

Ph.D., Stanford University, 1991 NIH Postdoctoral Fellow, Harvard University, 1991-1993

研究领域

Organic and Organometallic Chemistry

The interrelated aspects of our research program include introducing new chemical transformations, building complex molecules with these new reactions, and using these compounds to study cellular function. The development of new reactions continues to be an important endeavor in organic chemistry. Our efforts have been directed toward discovering better ways of constructing medium-ring-containing compounds. Using novel transformations that build molecular complexity rapidly have allowed for the efficient construction of seven- and eight-membered ring, containing natural products. Moreover, we have also investigated whether there are new ways to discover new reactions. In this regard, we have found that "rational selection" protocols using combinatorial techniques can provide very attractive catalytic solutions to longstanding chemical problems. Employing new reactions in the total synthesis of challenging molecules is not only important for organic chemistry; it also allows us to contribute to biological chemistry. Building molecules with unique or unusual biological activities can offer powerful new tools for studying biological systems. For example, we have used the synthesis ofilimaquinone, a marine sponge metabolite, to uncover previously unknown functional aspects of the Golgi apparatus. Similarly, other natural products currently under study will be used to provide a better understanding of the biological systems they influence. Combining organic chemistry with select techniques in protein chemistry and molecular and cellular biology yields a powerful multidisciplinary approach for advancing our understanding of various important scientific issues.

近期论文

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Enantioselective Silyl Protection of Alcohols Catalyzed by an Easily Available Amino Acid-Based Small-Molecule" Zhao, Y.; Rodrigo, J.; Hoveyda, A. H.; Snapper, M.L. Nature 2006. Sept 7. "Solvent-Controlled Intramolecular [2+2] Photocycloadditions of Substituted Enones" Ng, S.M.; Bader, S.J.; Snapper, M.L. J. Am. Chem. Soc. 2006, 128, 7315. "Preparation of Alkenyl Cyclopropanes through a Ruthenium-Catalyzed Tandem Enyne Metathesis-Cyclopropanation Sequence" Kim, B.G.; Snapper, M.L. J. Am. Chem. Soc. 2006, 128, 52. "Functionalized Oxepines via Fragmentation of Highly Strained Epoxides" Leyhane, Andrew J.; Snapper, Marc L. Org. Lett. 2006, 8, 5183. "Conformationally Restricted (+)-Cacospongionolide B Analogues. Influence on Secretary Phospholipase A2 Inhibition" Murelli, Ryan P.; Cheung, Atwood K; Snapper, Marc L. J. Org. Chem. 2006, 72, 1545. "A Highly Efficient and Practical Method for Catalytic Asymmetric Vinylogous Mannich (AVM) Reactions" Carswell, Emma L.; Snapper, Marc L.; Hoveyda, Amir H. Angew. Chem. Int. Ed. 2006, 45, 7230. "Intramolecular Cyclobutadiene Cycloaddition/Cyclopropanation/Thermal Rearrangement: An Effective Strategy for the Asymmetric Syntheses of Pleocarpenene and Pleocarpenone" Williams, Michael J.; Deak, Holly L.; Snapper, Marc. L. J. Am. Chem. Soc. 2007, 129, 486. "Conjugated Ruthenium- Catalyzed Tandem Cross-Metathesis/Wittig Olefination: Generation of Conjugated Dienoic Esters from Terminal Olefins" Murelli, Ryan P.; Snapper, Marc L. Org. Lett.2007, 9, 1749. "Conformationally Restricted (+)- Cacospongionolide B Analogues. Influence on Secretary Phospholipase A2 Inhibition." Murelli, Ryan P.;Cheung, Atwood K.;Snapper, Marc L.. J. Org. Chem. 2007, 72, 1545. "Selective synthesis of ent-15-epi-F2t-isoprostane and a deuterated derivative." Shizuka, Manami; Snapper, Marc L.. Synthesis. 2007, 15, 2397 "Kinetic resolution of 1,2-diols through highly site - and enantioselective catalytic silylation" Zhao, Yu; Mitra, Aupron W.; Hoveyda, Amir H,; Snapper, Marc L.. Angew. Chem. Int. Ed. 2007, 46,8471 "A Cross-Metathesis Route to the 5-F2-Isoprostanes." Pandya, Bhaumik A.; Snapper, Marc L.. J. Org. Chem. 2008, 73, 3754 "Catalytic Asymmetirc Alkylations of Ketoimines. Enantioselective Synthesis of N-Substituted Quaternary Carbon Stereogenic Centers by Zr-Catalyzed Additions of Dialkylzinc Reagents to Aryl-, Alkyl-, and Trifluoroalkyl- Substituted Ketoimines" Fu, Peng; Snapper, Marc L.; Hoveyda, Amir H.. J. AM. Chem. Soc. 2008, 130, 5530. "Catalytic Enantioselective Hosomi-Sakurai Conjugate Allylation of Cyclic Unsaturated Ketoesters" Shizuka, Manami; Snapper, Marc L. Angew. Chem. Int. Ed. 2008, 47, 5049. "Aluminum-Catalyzed Asymmetric Alkylations of Pyridyl-Substituted Alkynyl Ketones with Dialkylzinc Reagents" Friel, Donna K.; Snapper, Marc L.; Hoveyda, Amir H. J. Am. Chem. Soc. 2008, 130, 9942. "Three-Component Ag-Catalyzed Enantioselective Vinylogous Mannich and Aza-Diels-Alder Reactions with Alkyl-Substituted Aldehydes" Mandai, Hiroki; Mandai, Kyoko; Snapper, Marc L.; Hoveyda, Amir H. J. Am. Chem. Soc. 2008, 130, 17961. "Ruthenium-catalyzed tandem enyne-cross metathesis–cyclopropanation: three-component access to vinyl cyclopropanes" Murelli, Ryan P.; Catalan, Silvia; Gannon, Michael P.; Snapper, Marc L. Tetrahedron Lett. 2008, 49, 5714. "Catalytic Enantioselective Silylation of Acyclic and Cyclic Triols: Application to Total Syntheses of Cleroindicins D, F, and C" You, Zhen; Hoveyda, Amir H.; Snapper, Marc L. Angew. Chem. Int. Ed. 2009, 48, 547. "Ag-Catalyzed Diastereo- and Enantioselective Vinylogous Mannich Reactions of r-Ketoimine Esters. Development of a Method and Investigation of its Mechanism" Wieland, Laura C.; Vieira, Erika M.; Snapper, Marc L.; Hoveyda, Amir H. J. Am. Chem. Soc. 2009, 131, 570. "A new structural class of S-adenosylhomocysteine hydrolase inhibitors" Kim, Byung Gyu; Chun, Tae Gyu; Lee, Hee-Yoon; Snapper, Marc L. Bioorg. Med. Chem. 2009, 17, 6707.