个人简介

Ph.D. Boston College, 1995 NSF Postdoctoral Fellow, Harvard University, 1995-1997

研究领域

Organic and Organometallic Chemistry

Synthetic organic chemistry has undergone a paradigm shift over the past 15 years with new metal-catalyzed transformations enabling bond formation in ways that chemists previously only dreamed about. Realizing the impact that new catalytic asymmetric reactions will have on the continued evolution of organic synthesis, we have focused our research on the development of new processes and on studying their utility in complex molecule synthesis. Control of enantioselectivity is an overarching theme as adequate control of molecular shape is paramount in the design of effective therapeutics, materials, and commodity chemicals. Our progress towards these goals depends upon expertise in many areas of chemistry including organometallic chemistry, physical organic chemistry, and synthetic organic chemistry. Additionally, computational chemistry plays a central role in ligand design and in prediction of reaction outcomes. Efforts in new reaction development are intimately intertwined with efforts in total synthesis of natural products. Our approaches to the natural products borrelidin, inostamycin, fraxinellone and dihydroxanthatin all served to highlight the utility of newly developed reactions and serve as a device to measure the limitations of catalytic methods. In addition to expanding the frontiers of chemistry, these studies prepare students for a variety of careers that involve the synthesis and manipulation of chemical structures.

近期论文

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"Synthesis of Vinyl Boronates from Aldehydes by a practical Boron-Wittig Reaction" J. R. Coombs, L. Zhang, and J. P. Morken, Org Lett. 2015, Accepted. DOI: 10.1021/acs.orglett.5b00480 "Diastereoselective Ni-catalyzed 1,4-hydroboration of chiral dienols" R. J. Ely, Z. Yu, and J. P. Morken. Tetrahedron Lett (Wasserman Memorial Issue), 2015, Accepted. doi:10.1016/j.tetlet.2015.01.123 "Nonracemic Allylic Boronates through Enantiotopic-Group-Selective Cross-Coupling of Geminal (bis)Boronates and Vinyl Halides" B. Potter, A. A. Szymaniak, E. K. Edelstein, and J. P. Morken. J. Am. Chem. Soc. 2014, 136, 17918. "Enantiomerically Enriched Tris(boronates): Readily Accessible Conjunctive Reagents for Asymmetric Synthesis" J. R. Coombs, L. Zhang, and J. P. Morken. J. Am. Chem. Soc. 2014, 136, 16140. "Enantioselective Carbocyle Formation through Intramolecular Pd-Catalyzed Allyl-Aryl Cross-Coupling" C. H. Schuster, J. R. Coombs, Z. A. Kasun, and J. P. Morken Org. Lett. 2014, 16, 4420. "Simple Access to Elusive α-Boryl Carbanions and Their Alkylation: An Umpolung Construction for Organic Synthesis" K. Hong, X. Liu, and J. P. Morken J. Am. Chem. Soc. 2014, 136, 10581. "Synthesis of (+)-Discodermolide by Catalytic Stereoselective Borylation Reactions" Z. Yu, R. J. Ely, and J. P. Morken Angew. Chemie. Int. Ed. 2014, 126, 9786-9790. "Congested C–C Bonds by Pd-Catalyzed Enantioselective Allyl–Allyl Cross-Coupling, a Mechanism-Guided Solution" M. J. Ardolino and J. P. Morken J. Am. Chem. Soc. 2014, 136, 7092-7100. "A Catalytic Enantiotopic-Group-Selective Suzuki Reaction for the Construction of Chiral Organoboronates" C. Sun, B. Potter and J. P. Morken J. Am. Chem. Soc. 2014, 136, 6534-6537. "Asymmetric Synthesis from Terminal Alkenes by Cascades of Diboration and Cross-Coupling" S. N. Mlynarski, C. H. Schuster and J. P. Morken Nature 2014, 505, 386-390. "A Catalytic Enantioselective Tandem Allylation Strategy for Rapid Terpene Construction: Application to the Synthesis of Pumilaside Aglycon" G. E. Ferris, K. Hong, I. A. Roundtree and J. P. Morken J. Am. Chem. Soc. 2013, 135, 2501-2504.