个人简介

Ph.D., Yale University, 1986 American Cancer Society Postdoctoral Fellow, Harvard University, 1986–87; 1988–90

研究领域

Organic and Organometallic Chemistry

We discover, design and develop new catalysts for chemical synthesis that are easily prepared, are stable to air and moisture and can be recycled. We introduce efficient new chiral catalysts that can be used to synthesize important enantiomerically pure compounds for the preparation of biologically and medicinally active agents. Our focus is on transformations that are truly important (such as conjugate additions and olefin metathesis), but cannot be catalyzed efficiently by existing methods. We are interested in complex molecule total synthesis (testing our catalysts), study of reaction mechanism (how do our catalysts work?) and new approaches to catalyst discovery (combinatorial chemistry).

近期论文

查看导师最新文章 （温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

“Synthesis of Linear (Z)-,-Unsaturated Esters by Catalytic Cross-Metathesis. The Influence of Acetonitrile,” E. C. Yu, B. M. Johnson, E. M. Townsend, R. R. Schrock, A. H. Hoveyda Angew. Chem., Int. Ed. 2016, 55, 13210. “Catalytic Enantioselective 1,6-Conjugate Additions of Propargyl and Allyl Groups,” F. Meng, X. Li, S. Torker, Y. Shi, X. Shen, A. H. Hoveyda Nature 2016, 537, 387. “Catalytic Enantioselective Conjugate Additions of (pin)B-Substituted Allylcopper Compounds Generated in situ from Butadiene or Isoprene,” X. Li, F. Meng, S. Torker, Y. Shi, A. H. Hoveyda Angew. Chem., Int. Ed. 2016, 55, 9997. “Practical and Broadly Applicable Catalytic Enantioselective Additions of Allyl–B(pin) Compounds to Ketones and -Ketoesters,” D. W. Robbins, K. Lee, D. L. Silverio, A. Volkov, S. Torker, A. H. Hoveyda Angew. Chem., Int. Ed. 2016, 55, 9610. “Catalytic Enantioselective Addition of Organoboron Reagents to Fluoroketones Controlled by Electrostatic Interactions,” K. Lee, D. L. Silverio, S. Torker, F. Haeffner, D. W. Robbins, F. W. van der Mei, A. H. Hoveyda Nature Chemistry 2016, 8, 768. “Kinetically E-Selective Olefin Metathesis Reactions,” T. T. Nguyen, M. J. Koh, X. Shen, F. Romiti, R. R. Schrock, A. H. Hoveyda Science 2016, 352, 569. “Controllable ROMP Tacticity by Harnessing the Fluxionality of Stereogenic-at-Ruthenium Complexes," M. S. Mikus, S. Torker, A. H. Hoveyda Angew. Chem., Int. Ed. 2016, 55, 4997. “Lewis Acid Catalyzed Borotropic Shifts in the Design of Diastereo- and Enantioselective -Additions of Allylboron Moieties to Aldimines,” F. W. van der Mei, H. Miyamoto, D. L. Silverio, A. H. Hoveyda Angew. Chem., Int. Ed. 2016, 55, 4701. “Catalytic SN2'- and Enantioselective Allylic Substitution with a Diborylmethane Reagent and Application in Synthesis,” Y. Shi, A. H. Hoveyda Angew. Chem., Int. Ed. 2016, 55, 3455. “Direct Synthesis of Z-Alkenyl Halides through Catalytic Cross-Methathesis,” M. J. Koh, T. T. Nguyen, H. Zhang, R. R. Schrock, A. H. Hoveyda Nature 2016, 531, 459. “Regarding a Persisting Puzzle in Olefin Metathesis with Ru Complexes: Why are Transformations of Alkenes with a Small Substituent Z-Selective?,” S. Torker, M. J. Koh, R. K. Khan, A. H. Hoveyda Organometallics 2016, 35, 543. “Mechanism of NHC-Catalyzed Conjugate Additions of Diboron and Borosilane Reagents to ,-Unsaturated Carbonyl Compounds,” H. Wu, J. M. Garcia, F. Haeffner, S. Radomkit, A. R. Zhugralin, A. H. Hoveyda J. Am. Chem. Soc. 2015, 137, 10585. “N-Heterocyclic Carbene–Copper-Catalyzed Group-, Site-, and Enantioselective Allylic Substitution with a Readily Accessible Propargyl(pinacolato)boron Reagent: Utility in Stereoselective Synthesis and Mechanistic Attributes,” Y. Shi , B. Jung , S. Torker, A. H. Hoveyda J. Am. Chem. Soc. 2015, 137, 8948. “N-Substituted Tertiary and O-Substituted Quaternary Carbon Stereogenic Centers by Site-, Diastereo- and Enantioselective Vinylogous Mannich Reactions,” D. L. Silverio, P. Fu, E. L. Carswell, M. L. Snapper, A. H. Hoveyda Tetrahedron Lett. 2015, 56, 3489.(Special issue in memory of Professor Harry H. Wasserman) “Synthesis of Molybdenum and Tungsten Alkylidene Complexes that Contain the 2,6-Bis(2,4,6-triisopropylphenyl)phenylimido (NHIPT) Ligand,” J. C. Axtell, R. R. Schrock, Peter Müller, A. H. Hoveyda Organometallics 2015, 34, 2110. “Synthesis of Alternating trans-AB Copolymers through Ring-Opening Metathesis Polymerization Initiated by Molybdenum Alkylidenes,” H. Jeong, J. M. John, R. R. Schrock, A. H. Hoveyda J. Am. Chem. Soc. 2015, 137, 2239. "High-Value Alcohols and Higher-Oxidation-State Compounds by Catalytic Z-Selective Cross-Metathesis," M. J. Koh, R. K. M. Khan, S. Torker, M. Yu, M. S. Mikus, A. H. Hoveyda Nature 2015, 517, 181. “Catalyst-Controlled Stereoselective Olefin Metathesis as a Principal Strategy in Multistep Synthesis Design: A Concise Route to (+)-Neopeltolide,” M. Yu, R. R. Schrock, A. H. Hoveyda Angew. Chem., Int. Ed. 2015, 54, 215.