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Wee1InhibitorAZD1775EffectivelyInhibitstheMalignantPhenotypesofEsophagealSquamousCellCarcinomaInVitroandInVivo.BiS,WeiQ,ZhaoZ,ChenL,WangC,XieS.FrontPharmacol.2019Aug2;10:864.doi:10.3389/fphar.2019.00864.eCollection2019.
DKK1inhibitsbreastcancercellmigrationandinvasionthroughsuppressionofβ-catenin/MMP7signalingpathway.NiuJ,LiXM,WangX,LiangC,ZhangYD,LiHY,LiuFY,SunH,XieSQ,FangD.CancerCellInt.2019Jun24;19:168.doi:10.1186/s12935-019-0883-1.eCollection2019.
ElucidationoftheDifferencesinCinobufotalin'sPharmacokineticsBetweenNormalandDiethylnitrosamine-InjuredRats:TheRoleofP-Glycoprotein.ZhangX,LiuT,ZhangY,LiuF,LiH,FangD,WangC,SunH,XieS.FrontPharmacol.2019May17;10:521.doi:10.3389/fphar.2019.00521.eCollection2019.
Suppressionofepidermalgrowthfactorreceptor-mediatedβ-cateninnuclearaccumulationenhancestheanti-tumoractivityofphosphoinositide3-kinaseinhibitorinbreastcancer.NiuJ,WangX,LiangC,ZhangYD,LiuFY,LiHY,XieSQ,SunH,FangD.CellBiolInt.2019Aug;43(8):931-939.doi:10.1002/cbin.11183.Epub2019Jun18.
Targetingp21-activatedkinase1inhibitsgrowthandmetastasisviaRaf1/MEK1/ERKsignalinginesophagealsquamouscellcarcinomacells.ChenL,BiS,HouJ,ZhaoZ,WangC,XieS.CellCommunSignal.2019Apr11;17(1):31.doi:10.1186/s12964-019-0343-5.
InhibitionofPIKfyveusingYM201636suppressesthegrowthoflivercancerviatheinductionofautophagy.HouJZ,XiZQ,NiuJ,LiW,WangX,LiangC,SunH,FangD,XieSQ.OncolRep.2019Mar;41(3):1971-1979.doi:10.3892/or.2018.6928.Epub2018Dec12.
UridinediphosphatereleasemechanisminO-N-acetylglucosamine(O-GlcNAc)transferasecatalysis.SheN,ZhaoY,HaoJ,XieS,WangC.BiochimBiophysActaGenSubj.2019Mar;1863(3):609-622.doi:10.1016/j.bbagen.2018.12.005.Epub2018Dec11.
Akt1inhibitionpromotesbreastcancermetastasisthroughEGFR-mediatedβ-cateninnuclearaccumulation.LiW,HouJZ,NiuJ,XiZQ,MaC,SunH,WangCJ,FangD,LiQ,XieSQ.CellCommunSignal.2018Nov16;16(1):82.doi:10.1186/s12964-018-0295-1.
ProtectedandDe-protectedPlatinum(IV)GlycoconjugatesWithGLUT1andOCT2-MediatedSelectiveCancerTargeting:DemonstratedEnhancedTransporter-MediatedCytotoxicPropertiesinvitroandinvivo.MaJ,LiuH,XiZ,HouJ,LiY,NiuJ,LiuT,BiS,WangX,WangC,WangJ,XieS,WangPG.FrontChem.2018Sep21;6:386.doi:10.3389/fchem.2018.00386.eCollection2018.
SulfationdispositionofliquiritigenininSULT1A3overexpressingHEK293cells:Theroleofbreastcancerresistanceprotein(BCRP)andmultidrugresistance-associatedprotein4(MRP4)insulfateeffluxofliquiritigenin.LiuT,ZhangX,ZhangY,HouJ,FangD,SunH,LiQ,XieS.EurJPharmSci.2018Nov1;124:228-239.doi:10.1016/j.ejps.2018.08.041.Epub2018Aug31.
SynthesisandbiologicalevaluationofnovelasymmetricnaphthalenediimidederivativesasanticanceragentsdependingonROSgeneration.XuX,WangS,ChangY,GeC,LiX,FengY,XieS,WangC,DaiF,LuoW.Medchemcomm.2018Jul6;9(8):1377-1385.doi:10.1039/c8md00265g.eCollection2018Aug1.
DiscoveryofthePolyamineConjugatewithBenzo[cd]indol-2(1H)-oneasaLysosome-TargetedAntimetastaticAgent.LiJ,TianR,GeC,ChenY,LiuX,WangY,YangY,LuoW,DaiF,WangS,ChenS,XieS,WangC.JMedChem.2018Aug9;61(15):6814-6829.doi:10.1021/acs.jmedchem.8b00694.Epub2018Jul23.
SensitizationofTRPV1receptorsbyTNF-αorchestratesthedevelopmentofvincristine-inducedpain.WangY,FengC,HeH,HeJ,WangJ,LiX,WangS,LiW,HouJ,LiuT,FangD,XieSQ.OncolLett.2018Apr;15(4):5013-5019.doi:10.3892/ol.2018.7986.Epub2018Feb7.
Theleadoptimizationofthepolyamineconjugateofflavonoidwithanaphthalenemotif:Synthesisandbiologicalevaluation.LiQ,ZhuZX,ZhangX,LuoW,ChangLP,ChenS,WangYX,XieSQ,ChangCC,WangCJ.EurJMedChem.2018Feb25;146:564-576.doi:10.1016/j.ejmech.2018.01.074.Epub2018Jan31.
Synthesisandbiologicalevaluationofnaphthalimide-polyamineconjugatesmodifiedbyalkylationasanticanceragentsthroughp53pathway.DaiF,HeH,XuX,ChenS,WangC,FengC,TianZ,DongH,XieS.BioorgChem.2018Apr;77:16-24.doi:10.1016/j.bioorg.2017.12.036.Epub2018Jan4.
Synthesisandbiologicalevaluationofnovelalkylatedpolyamineanaloguesaspotentialanticanceragents.LiM,WangY,GeC,ChangL,WangC,TianZ,WangS,DaiF,ZhaoL,XieS.EurJMedChem.2018Jan1;143:1732-1743.doi:10.1016/j.ejmech.2017.10.069.
MEKinhibitor,PD98059,promotesbreastcancercellmigrationbyinducingβ-cateninnuclearaccumulation.ZhaoY,GeCC,WangJ,WuXX,LiXM,LiW,WangSS,LiuT,HouJZ,SunH,FangD,XieSQ.OncolRep.2017Nov;38(5):3055-3063.doi:10.3892/or.2017.5955.Epub2017Sep13.
Design,SynthesisandEvaluationofNaphthalimideDerivativesasPotentialAnticancerAgentsforHepatocellularCarcinoma.GeC,ChangL,ZhaoY,ChangC,XuX,HeH,WangY,DaiF,XieS,WangC.Molecules.2017Feb22;22(2).pii:E342.doi:10.3390/molecules22020342.
Design,Synthesis,andBiologicalEvaluationofMitochondria-TargetedFlavone-Naphthalimide-PolyamineConjugateswithAntimetastaticActivity.DaiF,LiQ,WangY,GeC,FengC,XieS,HeH,XuX,WangC.JMedChem.2017Mar9;60(5):2071-2083.doi:10.1021/acs.jmedchem.6b01846.Epub2017Feb21.
Extracellularpolyamines-inducedproliferationandmigrationofcancercellsbyODC,SSAT,andAkt1-mediatedpathway.DaiF,YuW,SongJ,LiQ,WangC,XieS.AnticancerDrugs.2017Apr;28(4):457-464.doi:10.1097/CAD.0000000000000465.
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