研究领域

研究领域：生化与分子生物学

研究兴趣：

1. 细胞内蛋白质的运输机制，阐释植物细胞中蛋白质从内质网运出并到达最终目的地的运输途径的分子机制。

2. 植物对环境的应答，探索植物适应环境变化的机制。

近期论文

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▲ Lixin Li, Ahmed Atef, Agnieszka Piatek1, Zahir Ali, Marek Piatek, Altan Sharakou, Mustapha Aouida, Ali Mahjoub, Guangchao Wang, Suhail Khan, Nina V. Fedoroff and Magdy M. Mahfouz Characterization and DNA Binding Specificities of Ralstonia TAL-like Effectors Nucleic Acids Research submitted ▲ Lixin Li, Tomoo Shimada, Hideyuki Takahashi, Yasuko Koumoto, Makoto Shirakawa, Junpei Takagi, Baoyu Tu, Hongmin Jin, Baoda Han, Meihui Jia, Maki Kondo, Mikio Nishimura and Ikuko Hara-Nishimura A complex comprised of MAG2 and three MAG2 INTERACTING PROTEINs, an ER-localized tethering machinery, is required for efficient transport of seed storage proteins in Arabidopsis plant journal under second review ▲ Mahfouz MM, Li L. TALE nucleases and next generation GM crops. GM Crops. 2011 Apr-Jun;2(2):99-103 ▲ Mahfouz MM, Li L, Shamimuzzaman M, Wibowo A, Fang X, Zhu JK De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks. Proc Natl Acad Sci U S A 2011 Feb 8;108(6):2623-8 ▲ Mahfouz MM, Li L, Piatek M, Fang X, Mansour H, Bangarusamy DK, Zhu JK. Targeted transcriptional repression using a chimeric TALE-SRDX repressor protein. Plant Mol Biol 2012 Feb;78(3):311-21 ▲ Li L, Piatek MJ, Atef A, Piatek A, Wibowo A, Fang X, Sabir JS, Zhu JK, Mahfouz MM. Rapid and highly efficient construction of TALE-based transcriptional regulators and nucleases for genome modification. Plant Mol Biol. 2012 Mar;78(4-5):407-16 ▲ Ryohei Thomas Nakano, Ryo Matsushima, Haruko Ueda, Kentaro Tamura, Tomoo Shimada, Lixin Li, Maki Kondo, Mikio Nishimura, and Ikuko Hara-Nishimura ERMO1/GNL1 and ERMO2/SEC24 Are Required for Maintenance of ER Morphology in Arabidopsis thaliana Plant Cell 2009 Nov;21(11):3672-85. ▲ Tomoo Shimada, Yasuko Koumoto, Lixin Li, Misako Yamazaki, Maki Kondo, Mikio Nishimura　and Ikuko Hara-Nishimura AtVPS29, a Putative Component of Retromer, is Required for the Efficient Sorting of Storage Proteins Plant Cell Physiology Vol. 47, No. 9, 1187-1194, September, 2006 ▲ Lixin Li, Tomoo Shimada, Hideyuki Takahashi, Yoichiro Fukao, Maki Kondo, Mikio Nishimura, and Ikuko Hara-Nishimura. MAIGO2 Is Involved in Exit of Seed Storage Proteins from the Endoplasmic Reticulum in Arabidopsis thaliana Plant Cell Vol. 18, 3535–3547, 2006