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(1)小分子药物靶向治疗 (2)肿瘤药物研究

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1. (First author) S.X. Wang#, Z. Du#, J. Luo, X. Wang, H. Li, Y. Liu, Y. Zhang, J. Ma, W. Xiao, Y. Wang*, X. Zhong*, Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer. Journal of cancer research and clinical oncology (2015). 2. (Co-first author) Y. Zhang#, S.X. Wang#, J.W. Ma, H.Y. Li, J.C. Ye, S.M. Xie, B. Du*, X.Y. Zhong*, EGCG inhibits properties of glioma stem-like cells and synergizes with temozolomide through downregulation of P-glycoprotein inhibition. Journal of neuro-oncology 121 (2015) 41-52. 3. (Corresponding author) Y.T. Liu#, X. Wang#, Y. Wang, Y. Zhang, K. Zheng, H.Z. Yan, L. Zhang, W.B. Chen, X.Y. Wang, Q.Y. Liu, S.X. Wang*, Y.F. Wang*, Combination of SNX-2112 with 5-FU exhibits antagonistic effect in esophageal cancer cells. International journal of oncology 46 (2015) 299-307. 4. (First author) S.X. Wang#, X. Wang#, Z. Du, Y.T. Liu, D.N. Huang, K. Zheng, K.S. Liu, Y. Zhang, X.Y. Zhong*, Y.F. Wang*, SNX-25a, a novel Hsp90 inhibitor, inhibited human cancer growth more potently than 17-AAG. Biochemical and biophysical research communications 450 (2014) 73-80. 5. (Corresponding author) K.S. Liu, H. Liu, J.H. Qi, Q.Y. Liu, Z. Liu, M. Xia, G.W. Xing, S.X. Wang*, Y.F. Wang*, SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells. Cancer letters 318 (2012) 180-188.

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