个人简介
贺海波,男,出生1972年1月,湖北鄂州人,中国药科大学药学博士,浙江大学药学博士后、副教授、硕士研究生导师,中国药理学会会员、中国中医药学会会员、中华中医药学会中药基础理论分会青年委员、世界中联药膳食疗研究专业委员会常务理事、中国民族医药学会理事、宜昌市药学会副会长、中医药学会副秘书长、三峡大学第二人民医院特聘教授。主要从事三峡库区及神农架林区民间药物化学成分分离纯化、活性评价,中药药理、毒理学研究,中药抗肿瘤及防治心脑血管、消化及内分泌代谢疾病研究,食品、保健品和新药的研究与开发,茶叶、青钱柳、湖北海棠、木瓜等相关药食同源产品的应用开发研究。近5年来,主持了国家、省部级及横向合作等科研项目20余项,发表科研论文60余篇,其中SCI/EI收录30余篇,获湖北省科技进步奖三等奖1项、中华中医药学会科技进步奖三等奖1项、宜昌市科技进步奖一等奖2项,获国家发明专利5项,主编专著2部,参与完成了“地奥心血康”、“更年安神胶囊”等新药的研究开发,主持完成了“复方杜仲降压胶囊”、“参芪咀嚼片”等保健品的研究与开发,主持完成“活血益肾颗粒”、“祛风活络颗粒”、“痔疮颗粒”等医院制剂的研究与开发,主持完成了鱼腥草复合袋泡茶、青钱柳茶等相关茶产品的研究与开发,木瓜食品的研究开发,保健型柑橘果醋的研究与开发,天麻保鲜、深加工等研究。
已申请专利和专著:
1.贺海波,邹坤,杨小姣,刘呈雄,白彩虹,王倩,汪鋆植,郭志勇,薛艳红,杨进.载体皂苷RCE-4在制备预防或治疗肿瘤的药物中的用途,2015,中国,专利号:ZL201510398812.0.
2.张继红,贺海波,刘雄,周继刚,石孟琼,罗涛,段砚方,李玉倩,蔡燕,覃慧林,珠子参皂苷诱导干细胞分化肝细胞及治疗肝病药物的应用.2015,中国,申请号:CN201510366605.7.
3.贺海波,张永峰,石孟琼,汪鋆植,覃慧林,刘呈雄,张继红.木瓜总三萜及其组分在制药中的应用,2015,中国,申请号:CN201510661042.4.
4.贺海波,覃慧林,石孟琼,张永峰,刘呈雄,汪鋆植,张继红,一种皱皮木瓜提取物,提取方法及其应用,2015,申请号:CN201510660595.8.
5.贺海波,邹坤,石孟琼,汪鋆植,覃慧林,刘光耀,梅志刚,程凡,柳蔚,文宏桥.一种含鱼腥草叶的复合保健茶及其应用,2014,中国,申请号:CN201410748468.9.
6.易国之,卢训丛,贺海波,陈涛.芦荟种植新技术[M],湖北:湖北科学技术出版社,2011.
7.贺海波,宋先仁,石孟琼,冯芹,汪鋆植.《肿瘤科中医特效药膳精粹》,华中科技大学出版社,127千字,2015.
近年来获得的科研奖励:
1.贺海波(2/13),益贞颗粒的研制及其在治疗围绝经期综合症中的应用.中华中医药学会,科学技术奖,三等奖,2016.
2.贺海波(2/7),益贞颗粒的研制及其在治疗围绝经期综合症中的应用,湖北省人民政府,湖北省科技进步奖,三等奖,2016.
3.贺海波(2/15),益贞颗粒的研制及其在治疗围绝经期综合症中的应用,宜昌市人民政府,宜昌市科技进步奖,一等奖,2014.
近五年科研项目
1.宜昌市科技局项目,A18-302-a02,青砖茶珍的制备及对肠道菌群失衡的调节作用研究,2019/01-2020/12,3万元,在研,主持;
2.省部级科研机构发布的开放基金,2016KXN03,基于清除ROS及自噬与凋亡互反馈调控研究珠子参皂苷抗心肌缺血/再灌注损伤的分子机制,2016/07-2018/06,2万元,在研,主持;
3.省部级科研机构发布的开放基金,2016NP05,鄂西土家族传统发酵豆豉后发酵期间菌相分析、纤溶酶高产菌株分离筛选及其活性评价,2016/07-2018/06,2万元,在研,主持;
4.宜昌市青钱柳生物科技有限公司合作项目,SDHZ2016028,青砖茶珍的制备及对肠道菌群失衡的调节作用研究,2016/03-2019/03,10万元,在研,主持;
5.安琪酵母股份有限公司合作项目,SDHZ2013020,酵母浸出物(Yeastextract)内毒素检测方法和去除工艺的建立及无血清培养基产品(含质量标准)的研发,2013/04-2016/03,30万元,在研,主持;
6.宜昌市中医院合作项目,SDHZ2012046,基于系统生物学理论的胸痹心痛证方证证治规律研究,2012/04-2014/12,10万元,已结题,主持;
近期论文
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1)HeHaibo,LiXiaomei,LiDaojun,DingYonghong,ZhangYongfeng,XuHaiyan,FengMinlu,XiangChangqing,ZhouJigang,ZhangJihong,LiuHongjun,ChenMaohua.SaponinsfromRhizomaPanacisMajorisattenuatemyocardialischemia/reperfusioninjuryviatheactivationoftheSirt1/FoxO1/Pgc-1αandNrf2/antioxidantdefensepathwaysinrats.PharmacognMag,2018,14(54):1-11.
2)WangJunzhi,ZhangPan,HeHaibo*,SeXinxin,SunWenjun,ChenBeiyan,ZhangLin,YanXiming,ZouKun.EburicoicacidfromLaetiporussulphureus(Bull.:Fr.)MurrillattenuatesinflammatoryresponsesthroughinhibitingLPS-inducedactivationofPI3K/Akt/mTOR/NF-κBpathwaysinRAW264.7cells.NaunynSchmiedebergsArchPharmacol,2017,390(8):845-856.
3)BaiCaihong,YangXiaojiao,ZouKun,HeHaibo*,WangJunzhi,QinHuilin,YuXiaoqin,LiuChengxiong,ZhengJuyan,ChengFan,ChenJianfeng.AntiproliferativeeffectofRCE-4fromReineckiacarneaonhumancervicalcancerHeLacellsbyinhibitingthePI3K/Akt/mTORsignalingpathwayandNF-κBactivation.NaunynSchmiedebergsArchPharmacol,2016,389(6):573-584.
4)ZhangQioayin,WangJunzhi,HeHaibo*,LiuHongbin,YanXiming,ZouKun.TrametenolicacidBreversesmultidrugresistanceinbreastcancercellsthroughregulatingtheexpressionlevelofP-glycoprotein.PhytotherRes,2014,28(7):1037-1044.
5)WeiNa,ZhangChangcheng,HeHaibo*,WangTing,LiuZhaoqi,LiuGuangyao,SunZhiwei,ZhouZhiyong,BaiCaihong,YuanDing.ProtectiveeffectofsaponinsextractfromPanaxjaponicusonmyocardialinfarction:involvementofNF-κB,Sirt1andmitogen-activatedproteinkinasesignallingpathwaysandinhibitionofinflammation.JPharmPharmacol,2014,66(11):1641-1651.
6)WangSa,HeHaibo*,XiaoShuzhang,WangJunzhi,BaiCaihong,NaWei,KunZou.ComparisonbetweenthecardioprotectiveeffectsoflabeledandunlabeledoleanoicacidwithnewBOPIMdyeonprimaryneonatalratcardiomyocytesfollowinghypoxia/reoxgenationinjury.PharmacologicalRep,2014,66(4):677-685.
7)HuangShaolan,HeHaibo*,ZouKun,BaiCaihong,XueYanhong,WangJunzhi,ChenJianfeng.Protectiveeffectoftomatineagainsthydrogenperoxide-inducedneurotoxicityinneuroblastoma(SH-SY5Y)cells.JPharmPharmacol,2014,66(4):844-854.
8)YuanDing,WangHongwu,HeHaibo*,JiaLiangliang,HeYumin,WangTing,ZengXiao,LiYuzhou,LiShouchao,ZhangChangcheng.ProtectiveEffectsoftotalFlavonoidsfromEpimediumonthemalemousereproductivesystemagainstcyclophosphamide-inducedoxidativeinjurybyup-regulatingtheexpressionsofSOD3andGPX1.PhytotherRes,2014,28(1):88-97.
9)JinGuilan,QinHuilin,HeHaibo*,ChengFan,GongDachun,XuBang,JiaLiangliang,XiWei,WangHongwu,XiangXiangfei.Neuroprotectiveeffectsofbreviscapineagainstoxidative-stress-InducedcelldeathinPC12cells:InvolvementofNrf2/HO-1pathway.MedicineSciencesandBioengineering,2014,277-282.
10)BaiCaihong,HeHaibo*,ChengFan,ZouKun,WangJunzhi,LiuGuangyao,DengWei,ChenZhifeng,ChenXiao,ChenJianfeng.AsteroidalsaponinRCE-4inhibitslipopolysaccharide-stimulatedinflammatoryresponsesviablockingPI3K/Akt-mediatedNF-κBactivationinRAW264.7cells.AppliedMechanicsandMaterials,2014,568-570:1901-1906.
11)WeiNa,YuanDing,HeHaibo*,XuYuanqing,ZhangChangcheng,WangTing,LiuChaoqi,LiuGuangyao.SaponinsfromPanaxjaponicasreducesmyocardialinfarctioninducedReactiveOxygenSpeciesproductionandcardiomyocyteapoptosisviaactivationoftheNrf-2pathway.AdvancedMaterialsResearch,2014,881-883:339-346.
12)BaiCaihong,HeHaibo*,ChengFan,WangJunzhi,ChenXiao,ZouKun,LiuGuangyao,ChenZhifeng,ChenJianfeng.CardioprotectiveeffectsofsaponinsfromRhizomaPanacisMajorisonmyocardialischemia/reperfusioninjuryviascavengingexcessivereactiveoxygenspecies.AdvancedMaterialsResearch,2014,165-172:165-172.
13)ZhangJihong,ShiMengqiong,HeHaibo*,BaiCaihong,WangJunzhi,ChengFan,LiuGuangyao,DengWei,ZouKun,ChenZhifeng.HepatoprotectiveeffectsofsaponinsfromRhizomaPanacisMajorisonhepaticfibrosisinducedbycarbontetrachlorideinrats.AppliedMechanicsandMaterials,2014,568-570,1915-1920.
14)WeiNa,YuanDing,HeHaibo*,XuYuanqing,ZhangChangcheng,WangTing,LiuChaoqi,LiuGuangyao.SaponinsfromPanaxjaponicasreducesmyocardialinfarctioninducedReactiveOxygenSpeciesproductionandcardiomyocyteapoptosisviaactivationoftheNrf-2pathway.AdvancedMaterialsResearch,2013,784-789:367-371.
15)Denggaigai,Wangjunzhi,ZhangQiaoyin,HeHaibo*,WuFangfang,FengTianyan,ZhouJigang,ZouKun,MasaoHattoric.HepatoprotectiveeffectsofPhloridzinonhepaticfibrosisinducedbycarbontetrachlorideagainstoxidativestress-triggereddamageandfibrosisinrats.Biol.Pharm.Bull,2012,35(7):1118-112.
16)HuilinQin,YongfengZhang,HaiboHe*,JunzhiWang,HuajunLuo.Totaltriterpenefromhaenomelesspeciosa(sweet)NakaionattenuatestheadjuvantinducedarthritisbyregulatingMAPK/NF-κBpathwayandpro-inflammatorycytokineinrats.(submittedtoJEthnopharmacol).
17)HaiboHe,HuilinQin,YongfengZhang,XiaomeiLI,XiaoqinLi,WeihongYan,YulingLi.ProtectiveeffectsoftotaltriterpenefromChaenomelesspeciosa(Sweet)Nakaiagainstindomethacin-inducedgastriculcerinratsandpotentialunderlyingmechanisms.(submittedtoJPharmPharmacol).