刘兴 - 中国科学院大学 - 现代农业科学学院

个人简介

教育背景 2008-09--2013-07 中国科学院水生生物研究所博士学位 2003-09--2007-07 武汉大学理学学士学位

研究领域

1)以斑马鱼作为模式生物，解析鱼类低氧耐受与低氧适应的遗传基础； 2)低氧信号转导的调控及其分子机制； 3)低氧信号与肿瘤转移和先天免疫的关系； 4)鱼类抗病与抗逆遗传育种。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

[1] Zeshan Lin#, Lei Chen#, Xianqing Chen#, Yingbin Zhong#, Yue Yang#, Wenhao Xia#, Chang Liu, Wenbo Zhu, Han Wang, Biyao Yan, Yifeng Yang, Xing Liu, Kjersti Sternang Kvie, Knut H？kon R？ed, Kun Wang, Wuhan Xiao, Haijun Wei, Guangyu Li, Rasmus Heller, M. Thomas P. Gilbert, Qiang Qiu*, Wen Wang*, Zhipeng Li*. Biological adaptations in the Arctic cervid, the reindeer (Rangifer tarandus). Science, 2019, 364 eaav6312. [2] Guangqing Yu#, Xing Liu#, Jinhua Tang, Chenxi Xu, Gang Ouyang, Wuhan Xiao*. Neddylation Facilitates the Antiviral Response in Zebrafish. Frontiers in Immunology, 2019, 10: 1432. [3] Chenxi Xu, Xing Liu, Huangyuan Zha, Sijia Fan, Dawei Zhang, Wuhan Xiao*. A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein. PLoS Pathogens, 2018, 18(8): e1007259. [4] Xiaolian Cai, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Wuhan Xiao*. Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish. Journal of Biological Chemistry, 2018, 293(40): 15370-15380. [5] Jing Wang, Dawei Zhang, Juan Du, Chi Zhou, Zhi Li, Xing Liu, Gang Ouyang, Wuhan Xiao*. Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity. Nucleic Acids Research, 2017, 45(22): 12700-12714.. [6] Xing Liu, Xiaolian Cai, Dawei Zhang, Chenxi Xu, Wuhan Xiao*. Zebrafish foxo3b negatively regulates anti-viral response through suppressing the transactivity of irf3 and irf7. Journal of Immunology, 2016, 197(12): 4736-4749. [7] Xing Liu#, Xiaolian Cai#, Bo Hu#, Zhichao Mei, Dawei Zhang, Gang Ouyang, Jing Wang, Wei Zhang, Wuhan Xiao*. Forkhead transcription factor (FOXO3a) modulates hypoxia signaling via up-regulation of the von Hippel-Lindau gene (VHL). Journal of Biological Chemistry, 2016, 291(49): 25692-25705. [8] Xing Liu, Zhu Chen, Gang Ouyang, Tieshan Song, Huageng Liang, Wei Liu, Wuhan Xiao*. ELL associated factor 2 (EAF2) inhibits transforming growth factor beta signaling through a direct interaction with Smad3. Journal of Biological Chemistry, 2015, 290(43): 25933-25945. [9] Xing Liu, Zhu Chen, Chenxi Xu, Xiaoqian Leng, Hong Cao, Gang Ouyang, Wuhan Xiao*. Repression of hypoxia-inducible factor alpha signaling by Set7-mediated methylation. Nucleic Acids Research, 2015, 43(10): 5081-5098. [10] Yu Chen, Chi Zhou, Wei Ji , Zhichao Mei, Bo Hu, Wei Zhang, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Jiangang Zhou, Wuhan Xiao*. ELL targets c-Myc for proteasomal degradation and suppresses tumour growth. Nature Communications, 2016, 7: 11057. [11] Juan Du, Dawei Zhang. Wei Zhang, Gang Ouyang, Jing Wang, Xing Liu, Sun Li, Wei Liu, Wuhan Xiao*. pVHL negatively regulates antiviral signaling by targeting MAVS for proteasomal degradation. Journal of Immunology, 2015, 195(4): 1782-1790. [12] Jing Wang, Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. The Von Hippel-Lindau protein suppresses androgen receptor activity. Molecular Endocrinology, 2014, 28(2): 239-248. [13] Zhu Chen, Xing Liu, Zhichao Mei, Zhou Wang*, Wuhan Xiao*. EAF2 suppresses HIF-1alpha transcriptional activity by disrupting its interaction with the co-activator CBP/p300. Molecular and Cellular Biology, 2014, 34(6): 1085-1099. [14] Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of Histone Deacetylase 1. Molecular and Cellular Biology, 2014, 34(4): 765-775. [15] Wei Ji, Jing Wang, Wei Zhang, Xing Liu, Gang Ouyang, Wuhan Xiao*. pVHL acts as a downstream target of E2F1 to suppress E2F1 activity. Biochemical Journal, 2014, 457: 185-195. [16] Jing-xia Liu, Dawei Zhang, Xunwei Xie, Gang Ouyang, Xing Liu, Yonghua Sun, Wuhan Xiao*. Eaf1 and Eaf2 negatively regulate canonical Wnt/beta-catenin signaling. Development, 2013, 140: 1067-1078. [17] Xi Feng, Xing Liu, Wei Zhang, Wuhan Xiao*. p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO Journal, 2011,30: 3397-3415.