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招生专业 071004-水生生物学 招生方向 鱼类免疫学,比较免疫学,感染免疫学 教育背景 2001-09--2005-01 中国科学院水生生物研究所 博士研究生 1998-09--2001-06 华中农业大学 硕士研究生 工作简历 2015-01~现在, 中国科学院水生生物研究所, 研究员 2009-04~2010-03,英国阿伯丁大学生命科学院, 访问学者 2008-06~2008-11,英国阿伯丁大学生命科学院, Honorary Research Fellow 2007-08~2015-01,中国科学院水生生物研究所, 副研究员 2005-02~2007-07,中国科学院水生生物研究所, 助理研究员 教授课程 水产动物病害防控与免疫学 奖励信息 (1) 湖北省优秀博士论文, , 省级, 2006 专利成果 ( 1 ) 一种抗菌蛋白及分离的核酸,抗菌药物和应用, 发明, 2018, 第 1 作者, 专利号: 201710973695.5 ( 2 ) 一种转录因子的核酸、蛋白质及其应用, 发明, 2019, 第 1 作者, 专利号: 201810512372.0 科研项目 ( 1 ) 鱼类模式识别受体在信号传导通路及免疫反应中的作用, 主持, 国家级, 2009-01--2012-12 ( 2 ) 淡水池塘集约化养殖的基础科学问题研究, 参与, 国家级, 2009-01--2013-12 ( 3 ) 草鱼肽聚糖识别蛋白不同剪接异构体在抗菌及炎症反应中的作用, 主持, 国家级, 2012-01--2015-12 ( 4 ) 斑马鱼胞内模式识别受体NLRC5在抗感染中的作用及其机制, 主持, 国家级, 2014-01--2017-12 ( 5 ) 斑马鱼CD44在胸腺T细胞发育以及免疫调节中的作用及其机制, 主持, 国家级, 2017-01--2020-12 ( 6 ) 鱼类组蛋白H2A基因的核苷酸多态性及其在病原感染中的作 用, 主持, 国家级, 2019-01--2022-12 参与会议 (1)鱼类NOD1/RIP2信号在幼鱼发育以及免疫反应中的调控作用及其机制 2018年鱼类分子免疫学前沿论坛 2018-10-15 (2)鱼类NLR和RLR受体的相互调控对免疫反应的影响 2018水生动物免疫学研讨会 2018-06-13 (3)鱼类模式识别受体在信号传导通路以及免疫反应中的作用 中国水产学会鱼病专业委员会学术讨论会 2013-11-05 (4)Activation of intracellular antiviral immune responses by antibacterial pattern recognition receptor NOD1 第一届鱼贝免疫学国际会议 2013-06-25

研究领域

比较免疫学;鱼类免疫学

近期论文

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(1) The negative regulation of piscine CD44c in viral and bacterial infection, Dev Comp Immunol., 2019, 通讯作者 (2) Nano-biotechnology: a new approach to treat and prevent malaria, Int J Nanomedicine, 2019, 通讯作者 (3) NS38 is required for aquareovirus replication via interaction with viral core proteins and host eIF3A, Virology, 2019, 通讯作者 (4) TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation., Front Immunol, 2018, 通讯作者 (5) The discrepancy function of NLRC5 isoforms in antiviral and antibacterial immune responses, Dev Comp Immunol, 2018, 通讯作者 (6) RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways., Front Immunol, 2018, 通讯作者 (7) Structural basis of AimP signaling molecule recognition by AimR in Spbeta group of bacteriophages, Protein Cell, 2018, 第 8 作者 (8) 大鲵短型肽聚糖识别蛋白PGRP-S的克隆及其功能研究, 水生生物学报, 2018, 通讯作者 (9) Structural insights into Cas13b-guided CRISPR RNA maturation and recognition, Cell Res, 2018, 其他(合作组作者) (10) Functional characterization of a short peptidoglycan recognition protein from Chinese giant salamander (Andrias davidianus), Oncotarget, 2017, 通讯作者 (11) Alternative Pre-mRNA Splicing in Mammals and Teleost Fish: A Effective Strategy for the Regulation of Immune Responses Against Pathogen Infection., Int J Mol Sci, 2017, 通讯作者 (12) Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes, Dev Comp Immunol, 2017, 通讯作者 (13) NOD1 deficiency impairs CD44a/Lck as well as PI3K/Akt pathway, Scientific Reports, 2017, 通讯作者 (14) NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-κB, and also MDA5, RIG-I and MAVS, Fish Shellfish Immunol, 2016, 第 2 作者 (15) TBK1-like transcript negatively regulates the production of IFN and IFN-stimulated genes through RLRs-MAVS-TBK1 pathway, Fish Shellfish Immunol, 2016, 通讯作者 (16) MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors, Dev Comp Immunol, 2015, 通讯作者 (17) Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish, Fish Shellfish Immunol, 2015, 通讯作者 (18) Transcriptomic analysis of the host response to an iridovirus infection in Chinese giant salamander, Andrias davidianus, Vet Res, 2015, 第 1 作者 (19) Expression and protective role of two novel NACHT-containing proteins in pathogen infection, Dev Comp Immunol, 2014, 通讯作者 (20) Molecular cloning and functional characterization of peptidoglycan recognition protein 6 in grass carp Ctenopharyngodon idella, Dev Comp Immunol, 2014, 通讯作者 (21) Melanoma differentiation-associated gene 5 in zebrafish provoking higher interferon-promoter activity through signalling enhancing of its shorter splicing variant, Immunology, 2014, 通讯作者 (22) Expression and functional characterization of PGRP6 splice variants in grass carp Ctenopharyngodon idella, Dev Comp Immunol, 2014, 通讯作者 (23) Intracellular interferons in fish: a unique means to combat viral infection, PLoS Pathog, 2013, 第 1 作者 (24) Functional characterization of a short peptidoglycan recognition protein, PGRP5 in grass carp Ctenopharyngodon idella., Fish Shellfish Immunol., 2013, 通讯作者 (25) Three goose-type lysozymes in the gastropod Oncomelania hupensis: cDNA sequences and lytic activity of recombinant proteins., Dev Comp Immunol., 2012, 第 3 作者 (26) Expression pattern, promoter activity and bactericidal property of β-defensin from the mandarin fish Siniperca chuatsi., Fish Shellfish Immunol., 2012, 通讯作者 (27) Expression and functional characterization of the RIG-1 like receptors MDA5 and LGP2 in rainbow trout Oncorhynchus mykiss, Journal of virology, 2011, 第 1 作者 (28) Characterization of two C-type lectin like-domain (CTLD)-containing proteins from the cDNA library of Chinese mitten crab Eriocheir sinensis, Fish Shellfish Immunol, 2011, 通讯作者 (29) Cloning of two rainbow trout nucleotide-binding oligomerization domain containing 2 (NOD2) splice variants and functional characterization of the NOD2 effector domains, Fish Shellfish Immunol, 2011, 第 1 作者 (30) Cloning and expression of Toll-like receptors 1 and 2 from a teleost fish, the orange-spotted grouper Epinephelus coioides, Vet Immunol Immunopathol, 2011, 第 3 作者

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