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个人简介

1983年毕业于南京大学生物系。1995年毕业于法国巴黎大学,获博士学位,1995年至1998年美国国立卫生研究院(NIH)博士后。1999年回中国医学科学院基础医学研究所,现任北京协和医学院教授,博士研究生导师。

研究领域

生殖系统免疫调节与相关的不孕不育。

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1.Jiang Q, Wang F, Shi L, Zhao X, Gong M, Liu W, Song C, Li Q, Chen Y, Wu H, and Han D. C-X-C Motif Chemokine Ligand 10 Produced by Mouse Sertoli Cells in Response to Mumps Virus Infection Induces Male Germ Cell Apoptosis. Cell Death Dis 2017; 8: e3146. 2.Su L, Cheng YC, Lee WM, Zhang M, Yang F, Zhao B, Han D, Liu Y, and Hu D. Abcb1a and Abcb1b Genes Function Differentially in Blood-Testis Barrier Dynamics in the Rat. Cell Death Dis 2017; 8: e3038. 3.Yan K, Feng D, Liang J, Wang Q, Deng L, Zhang X, Ling B, and Han D. Cytosolic DNA Sensor-Initiated Innate Immune Responses in Mouse Ovarian Granulosa Cells. Reproduction 2017; 153: 821-34. 4.王菲,韩代书。感染及免疫相关的男性不育。中国科学:生命科学,2017; 47:180-189 5.Wu H, Zhao X, Wang F, Jiang Q, Shi L, Gong M, Liu W, Gao B, Song C, Li Q, Chen Y, and Han D. Mouse Testicular Cell Type-Specific Antiviral Response against Mumps Virus Replication. Front Immunol 2017; 8: 117. 6.江倩, 赵祥, 薛社普, 韩代书. 睾丸免疫调节与睾丸炎: Tyro3/Axl/Mer 受体酪氨酸激酶与模式识别受体的功能. 科学通报, 2017; 62: 1153–1162 7.Ma W, Li S, Ma S, Jia L, Zhang F, Zhang Y, Zhang J, Wong G, Zhang S, Lu X, Liu M, Yan J, Li W, Qin C, Han D, Qin C, Wang N, Li X, and Gao GF. Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice. Cell 2016; 167: 1511-24.e10. 8.Wang Q, Wu H, Cheng L, Yan K, Shi L, Zhao X, Jiang Q, Wang F, Chen Y, Li Q, Han D. Mumps virus induces innate immune responses in mouse ovarian granulosa cells through the activation of Toll-like receptor 2 and retinoic acid-inducible gene I. Mol Cell Endocrinol. 2016; 436:183-94. 9.Cheng L, Chen Q, Zhu W, Wu H, Wang Q, Shi L, Zhao X, Han D. Toll-like Receptors 4 and 5 Cooperatively Initiate the Innate Immune Responses to Uropathogenic Escherichia coli Infection in Mouse Epididymal Epithelial Cells. Biol Reprod. 2016; 94:58. 10.Li N, Mruk DD, Mok KW, Li MW, Wong CK, Lee WM, Han D, Silvestrini B, Cheng CY. Connexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogenesis and barrier disruption. FASEB J. 2016; 30:1436-52. 11.Chen Q, Deng T, Han D. Testicular immunoregulation and spermatogenesis. Semin Cell Dev Biol. 2016. pii: S1084-9521(16)30019-2. 12.Wu H, Shi L, Wang Q, Cheng L, Zhao X, Chen Q, Jiang Q, Feng M, Li Q, Han D. Mumps virus-induced innate immune responses in mouse Sertoli and Leydig cells. Sci Rep. 2016; 6:19507 13.Deng T, Chen Q, Han D. The roles of TAM receptor tyrosine kinases in the mammalian testis and immunoprivileged sites. Front Biosci (Landmark Ed). 2016; 21:316-27. 14.Li N, Mruk DD, Mok KW, Li MW, Wong CK, Lee WM, Han D, Silvestrini B, Cheng CY. Connexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogenesis and barrier disruption. FASEB J. 2016; 30:1436-52. 15.Yan K, Cheng L, Liu P, Liu Z, Zhao S, Zhu W, Wang Q, Wu H, Han D. Polyinosinic-Polycytidylic Acid Perturbs Ovarian Functions Through Toll-Like Receptor 3-Mediated Tumor Necrosis Factor A Production in Female Mice. Biol Reprod. 2015; 93:11. 16.Li N, Mruk DD, Wong CK, Lee WM, Han D, Cheng CY. Actin-bundling protein plastin 3 is a regulator of ectoplasmic specialization dynamics during spermatogenesis in the rat testis. FASEB J. 2015; 29:3788-805. 17.Li N, Mruk DD, Wong CK, Han D, Lee WM, Cheng CY. Formin 1 Regulates Ectoplasmic Specialization in the Rat Testis Through Its Actin Nucleation and Bundling Activity. Endocrinology. 2015; 156:2969-83. 18.Zhu W, Zhao S, Liu Z, Cheng L, Wang Q, Yan K, Chen Q, Wu H, Han D. Pattern recognition receptor-initiated innate antiviral responses in mouse epididymal epithelial cells. J Immunol. 2015; 194:4825-35. 19.Liu Z, Zhao S, Chen Q, Yan K, Liu P, Li N, Cheng CY, Lee WM, Han D. Roles of Toll-like receptors 2 and 4 in mediating experimental autoimmune orchitis induction in mice. Biol Reprod. 2015; 92:63. 20.Yu L, Liu P, Liu Z, Zhu W, Yan K, Chen Q, Han D. p204-mediated innate antiviral responses in mouse adipose cells and their effects on cell functions. Immunol Cell Biol. 2015; 93:147-57.

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