研究领域
利用多能干细胞研究BMP相关信号转导通路在心肺血管病中的作用机制及探索新型治疗策略，包括：1．研究肺动脉血管中关键转录因子的特异相互作用蛋白及组织特异性的效应基因。2．对多功能干细胞进行分化，得到相关的心血管细胞；并进行体外和体内功能研究。3．研究致病突变对心肺血管发育的影响并模拟疾病建立干细胞靶向药物筛选平台。4．研究肺高压中相关炎症因素在疾病发生和发展中的作用机制。
近期论文
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1. Yanjiang Xing*, Shuang Zhao*, Qingxia Wei*, Shiqiang Gong, Xin Zhao, Fang Zhou, Rafia AI-Lamki, Daniel Ortmann, Mingxia Du, Roger Pedersen, Guangdong Shang, Shuyi Si, Nicholas W Morrell, Jun Yang*. A novel piperidine identified by stem cell based screening attenuates pulmonary arterial hypertension via regulating BMP2 and PTGS2 levels. Eur Respir J 2018; in press (https://doi.org/10.1183/13993003.02229-2017).
2. Qingxia Wei*, Shuang Zhao*, Fang Zhou*, Yanjiang Xing*, Shiqiang Gong, Jiakuan Zhao, Rafia Ai-Lamki, Daniel Ortmann, Xin Zhao, Mingxia Du, Mariaestela Ortiz, Roger Pedersen, Shuyi Si, Morrell W Nicholas, Jun Yang*. Identification of Id genes as major functional targets of BMP signalling in endothelial cells: Potential for screening and therapy. Presented at 11th Pulmonary Vascular Research Institute World Congress 2017.
3. Xiao Di , Dong Hua Ji, Yu Chen,Chang Wei Liu, Bao Liu, Jun Yang .Endovascular treatment of ectopic bronchial artery aneurysm with brachiocephalic artery stent placement and coil embolization: A case report and literature review. Medicine(Baltimore), 2016, 95(35): e4461.
4. Rafia S. Al-Lamki, Jun Wang, Jun Yang, Simon Pacey, Timothy Eisen, and John R. Bradley Tumor necrosisfactor receptor 2-signaling in CD133-expressing cells in renal clear cell carcinoma，Oncotarget，2016，7(17)：24111.
5. Shiqiang Gong ，Xiaowan Han，Xuehong Li，Xiaobo He，Jun Yang, Shuyi Si，Development of a high-throughput screening strategy for up-regulators of the OPG/RANKL ratio with the potential for anti-osteoporosis effects，J Biomol Screen，2016; 21(7):738-48.
6. Jun Yang, Li X, Morrell NW.Id proteins in the vasculature: from molecular biology to cardiopulmonary medicine. Cardiovasc Res. Dec 1;104(3):388-398, 2014（通讯并第一作者）.
7. Jun Yang, Xiaohui Li, Changxin Wu, Astrid Weiss, Ralph Schermuly, and Nicholas Morrell. Sildenafil Potentiates Bone Morphogenetic Protein Signaling in Pulmonary Arterial Smooth Muscle Cells and in Experimental Pulmonary Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology. 33(1), 34-41, 2013 （通讯并第一作者）.
8. Jun Yang, Xiaohui Li, Mark Southwood, Ye Linying, Nicholas W. Morrell. Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 305(4)，ppL312-L321, 2013（通讯并第一作者）.
9. Rafia S. Al-Lamki, Wanhua Lu, Jun Wang, Jun Yang, John R. Brdaley. TNF, Acting through inducibly expressed TNFR2, drives activation and cell cycle entry of c-kit+ cardiac stem cells in ischemic heart disease. Stem Cells. 31(9) : 1881-92，2013.
10. Takeshi Ogo, H. M. Chowdhury, Jun Yang, Lu Long, Xiaohui Li, Yamila N. Torres Cleuren, Nicholas W Morrell, Ralph T. Schermuly, Richard C. Trembath and Md. Talat Nasim. Inhibition of overactive TGF-signaling by prostacyclin analogues in pulmonary arterial hypertension (PAH). Am. J. Respir. Cell Mol. Biol. 48(6):733-41，2013.
11. Jun Yang, Xiaohui Li, Rafia Al-Lamki, Andrew lever, Nicholas W. Morrell. Induction Of Id1by Prostacyclin Analogues Inhibits Proliferation Of Pulmonary Artery Smooth Muscle Cells In Vitro And In Vivo. Circulation Research. 107(2), 252-262, 2010.
12. Hannah J. Durrington, Paul D. Upton, Simon Hoer, Jessica Boname, Benjamin Dunmore, Jun Yang, Nicholas W. Morrell. Identification of a lysosomal pathway regulating degradation of the bone morphogenetic protein receptor type-II. Journal of Biological Chemistry. 285(48): 37641-9，2010.
13. Xue Li, Jun Yang, Xiaobo He, Zhangyong Yang, Yan Ding, Huayi Shao, Zhuorong Li, Yueqin Zhang, Shuyi Si. Identification of BMP2 Up-regulators via High-Throughput Screening of a Synthetic and Natural Compound Library. Journal of Biomolecular Screening. 14(10)，1251-1256, 2009 (并列第一作者).
14. Mark Toshner, Robert Voswinkel, Mark Southwood, Rafia Al-Lamki, Jun Yang, Nicholas W. Morrell et al. Evidence for Dysfunction of Endothelial Progenitors in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 180(8) :780-7，2009.
15. Jun Yang, Rachel Davies, Lu Long, Xudong Yang, Paul Upton, Anastasia Sobolewski, Richard Trembath and Nick Morrell. Mutations in BMPRII cause dysregulation of Id gene expression in pulmonary arterial smooth muscle cells: Implication for familial pulmonary arterial hypertension. Circulation Research. 102(10), 1212-1221, 2008.
16. Anastasia Sobolewski, Nung Rudarakanchana, Jun Yang, Trina K. Jeffery, Richard Trembath, Nicholas W. Morrell. Functional rescue of mutant bone morphogenetic protein receptor type II in pulmonary arterial hypertension. Human Molecular Genetics. 17(20):3180-90，2008.
17. Jun Yang, Yueqin Zhang. Study on a novel anti-osteoporosis drug screening model targeted on Cathepsin K. Biomedical and Environmental Sciences. 17(3): 273-80, 2004.
18. Jun Yang, Shuyi Si, Yueqin Zhang. The regulation of SMAD in TGF-β superfamily signaling pathway [review]. China Biotechnology. 2003, 23(12).
19. Yan Ding, Jun Yang, Shuyi Si, Li Ruan.The mechanism of Statins upregulate BMP-2 expression in osteoblast. China Biotechnology，25(4): 18-21，2005.
20. Jun Yang, Bin Liu, Yueqin Zhang. Study on the screening model of anti-osteoporosis drugs targeting on cathepsin L. Chinese Journal of Antibiotics. 2002, 27(5):264-266.
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