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研究领域

1)朊病毒病慢性感染及跨种属传播机制的研究 2)朊病毒病蛋白组学的研究 3) 朊病毒病实验室监测技术的研究

近期论文

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1. Shi Q, Li JL, Ma Y, Gao LP, Xiao K, Wang J, Zhou W, Chen C, Guo YJ, Dong XP. Decrease of RyR2 in the prion infected cell line and in the brains of the scrapie infected mice models and the patients of human prion diseases. Prion,2018,20,1-30. (IF:2.241) 2. Shi Q Chen C, Zhou W, Gao C, Xiao K, Zhang J, Wang J, Zhang BY, Wang Y, Jun J, Dong XP. The characteristics of Chinese prion diseases based on 10 years surveillance data from 2006 to 2015. Neuropsychiatry (London), 2018,8(2),739-744(IF:4.471) 3. Xiao K, Shi Q, Zhou W, Gao C, Chen C, Zhang BY, Wang J, Dong XP. Evaluation of the influences of some main elements on the PrPSc detection of RT-QuIC assay. Int J Mol Med, (accepted)(co-first) (IF:2.341) 4. Wang J, Xiao K, Zhou W, Gao C, Chen C, Shi Q, Dong XP. A Chinese patient of P102L Gerstmann-Str?ussler-Scheinker syndrome contains three other disease-associated mutations in SYNE1. Prion, 2018,2,1-6(Co-Corres) (IF:2.241) 5. Shi Q, Xiao K, Zhou W, Wang J, Chen C, Gao C, Dong XP. Fatal familial insomnia: insight of the most common genetic prion disease in China based on the analysis of 40 patients. Neuropsychiatry (London), 2018,8(2),739-744 (IF:4.471) 6. Shi Q, Sun H, Chen C, Zhang BY, Zhou W, Gao C, Dong XP. Treatment of redox process induces diverse effects on the recombinant human wild-type PrP and the mutated PrP with inserted or deleted octarepeats. Int J Mol Med, 2018, 41: 2413-2419 (IF:2.341) 7. Yang XD, Shi Q, Sun J, Lv Y, Ma Y, Chen C, Xiao K, Zhou W, Dong XP. Aberrant alterations of mitochondrial factors Drp1 and Opa1 in the brains of scrapie experiment rodents. J Mol Neurosci, 2017, 61:368-378. (2.229)(Co-Corres) 8. Chen LN, Sun J, Yang XD, Xiao K, Lv Y, Zhang BY, Zhou W, Chen C, Gao C, Shi Q, Dong XP. The brain NO levels and NOS activities ascended in the early and middle stage and descended in the terminal stage in scrapie infected animal models. Mol Neurobiol, 2017, 54:1786-1796. (6.19) (Co-Corres) 9. Ma Y, Qi Shi , Jing Wang J, Xiao K, Jing Sun J, Lv Y, Guo M, Zhou W, Cao Chen C, Gao C, Zhang BY, Dong XP. Reduction of NF-κB (p65) in scrapie-infected cultured cells and in the brains of scrapie-infected rodents. ACS Chemical Neuroscience, 2017, 8:2535-2848(3.883) 10. Shi Q, Zhou W, Chen C, Xiao K, Wang Y, Gao C, Dong XP. Rare genetic Creutzfeldt-Jakob disease with T188K mutation: analysis of clinical, genetic and laboratory features of thirty Chinese patients. J Neurol Neurosurg Ps, 2017,88 (10):889-890(IF:7.349). 11. Shi Q, Chen LN, Lv Y, Zhang BY, Xiao K, Zhou W, Chen C, Sun J, Yang XD, Dong XP. Comparative proteomics analyses for 139A and ME7 scrapie infected mice brains in the middle and terminal stages. Proteom Clin Appl, 2017,11(5-6)(IF:3.81). 12. Guo YJ, Shi Q, Yang XD, Li JL, Ma Y, Xiao K, Chen C, Dong XP, Increases of Galectin-1 and its S-nitrosylated form in the brain tissues of scrapie infected rodent models and human prion diseases. Mol Neurobiol, 2017, 54:3707-3716 (IF:5.471) 13. Shi Q, Xiao K, Chen C, Zhou W, Gao C, Wang J, Zhang BY, Wang Y, Zhang F, Dong XP. Clinical and laboratory features of 14 young Chinese probable sCJD patients. Prion, 2017, 11:128-135. (IF:2.241) 14. Chen LN, Sun J, Yang XD, Xiao K, Lv Y, Zhang BY, Zhou W, Chen C, Gao C, Shi Q, Dong XP. The brain NO levels and NOS activities ascended in the early and middle stage and descended in the terminal stage in scrapie infected animal models. Mol Neurobiol, 2017, 54:1786-1796. (IF:5.471) 15. Yang XD, Shi Q, Sun J, Lv Y, Ma Y, Chen C, Xiao K, Zhou W, Dong XP. Aberrant alterations of mitochondrial factors Drp1 and Opa1 in the brains of scrapie experiment rodents. J Mol Neurosci, 2017,61(3):368-378.(IF:2.23) 16. Shi Q, Zhou W, Chen C, Gao C, Xiao K, Wang J, Zhang BY, Wang Y, Zhang F, Dong XP. Quality Evaluation for the Surveillance System of Human Prion Diseases in China Based on the Data from 2010 to 2016. Prion, 2016, 10:484-491(IF:2.241) 17. Shi Q, Zhou W, Chen C, Zhang BY, Xiao K, Wang Y, Dong XP. Rare E196A mutation in PRNP gene of three Chinese patients with Creutzfeldt-Jacob disease. Prion, 2016, 10:331-337(IF:2.241) 18. Chen LN, Shi Q, Zhang BY, Zhang XM, Wang J, Xiao K, Lv Y, Sun J, Yang XD, Chen C, Zhou W, Han J, Dong XP. Proteomic analyses for the global S-nitrosylated proteins in the brain tissues of different human prion diseases. Mol Neurobiol, 2016, 53:5079-5096(IF:5.471) 19. Xiao K, Zhang BY, Zhang XM, Wang J, Chen C, Chen LN, Lv Y, Shi Q, Dong XP. Re-infection of the prion from a scrapie infected cell line SMB-S15 onto three strains of mice, CD1, C57 and Balb/C. Int J Mol Med, 2016, 37:716-726( co-corresponding author) (IF:2.341) 20. Wei W, Shi Q, Zhang NS, Xiao K, Chen LN, Yang XD, Ji JF, Dong XP. The expressions of prion protein in head and neck squamous cell carcinomas closely associate with the pathological and clinical progressions and the abnormalities of p53. Oncol Rep, 2016, 35: 817-824(IF:2.301).

学术兼职

中国微生物学会病毒学专业委员会青年委员会青年委员,中国微生物学会病毒学分会医学病毒组常务秘书,中国微生物学会微生物生物安全专业委员会常务委员,中国医疗保健国际交流促进会分子诊断学分会常务委员

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