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个人简介

1982年毕业于西安医学院,1991-1994年德国Erlangen-Nuernburg大学博士学位。1995-1998年德国科隆大学病毒学研究所博士后、助理研究员。现任中国疾病预防控制中心传染病预防控制国家重点实验室副主任,全球公共卫生中心主任,病毒病所朊病毒病室主任。2006-2012年任中国疾病预防控制中心科技处处长,2012-2016年任中国疾病预防控制中心病毒病所副所长。2003-2013年任第十届、第十一届北京市政协委员。2013年至今任第十二届全国政协委员。

研究领域

(1)朊病毒和朊病毒病 (2)新发病毒性传染病 (3)肿瘤相关病毒

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. Shi Q, Zhou W, Chen C, Xiao K, Wang Y, Gao C, Dong XP. Rare genetic Creutzfeldt-Jakob disease with T188K mutation: analysis of clinical, genetic and laboratory features of thirty Chinese patients. J Neurol Neurosurg Ps, 2017 Oct;88(10):889-890 2. Shi Q, Chen LN, Lv Y, Zhang BY, Xiao K, Zhou W, Chen C, Sun J, Yang XD, Dong XP. Comparative proteomics analyses for 139A and ME7 scrapie infected mice brains in the middle and terminal stages. Proteom Clin Appl, 2017 May;11(5-6) 3. Shi Q, Xiao K, Chen C, Zhou W, Gao C, Wang J, Zhang BY, Wang Y, Zhang F, Dong XP. Clinical and laboratory features of 14 young Chinese probable sCJD patients. Prion, 2017, 11:128-135. 4. Chen LN, Sun J, Yang XD, Xiao K, Lv Y, Zhang BY, Zhou W, Chen C, Gao C, Shi Q, Dong XP. The brain NO levels and NOS activities ascended in the early and middle stage and descended in the terminal stage in scrapie infected animal models. Mol Neurobiol, 2017, 54:1786-1796. 5. Yang XD, Shi Q, Sun J, Lv Y, Ma Y, Chen C, Xiao K, Zhou W, Dong XP. Aberrant alterations of mitochondrial factors Drp1 and Opa1 in the brains of scrapie experiment rodents. J Mol Neurosci, 2017, 61:368-378. 6. Guo YJ, Shi Q, Yang XD, Li JL, Ma Y, Xiao K, Chen C, Dong XP, Increases of Galectin-1 and its S-nitrosylated form in the brain tissues of scrapie infected rodent models and human prion diseases. Mol Neurobiol, 2017, 54:3707-3716 7. Gao C, Han J, Zhang J, Wei J, Zhang BY, Tian C, Zhang J, Shi Q, Dong XP. Protein Misfolding Cyclic Amplification Cross-Species Products of Mouse-Adapted Scrapie Strain 139A and Hamster-Adapted Scrapie Strain 263K with Brain and Muscle Tissues of Opposite Animals Generate Infectious Prions. Mol Neurobiol. 2017 Jul;54(5):3771-3782. 8. Zhang RQ, Chen C, Xiao LJ, Sun J, Ma Y, Yang XD, Xu XF, Xiao K, Shi Q, Chen ZB, Dong XP. Aberrant alterations of the expressions and S-nitrosylation of calmodulin and the downstream factors in the brains of the rodents during scrapie infection. Prion, 2017, 11:352-367. 9. Chen C, Xu XF, Zhang RQ, Ma Y, Lv Y, Li JL, Shi Q, Xiao K, Sun J, Yang XD, Shi Q, Dong XP. Remarkable increases of a1-antichymotrypsin in brain tissues of rodents during prion infection. Prion, 2017, 11:5, 338-351 10. Ma Y, Shi Q, Wang J, Xiao K, Sun J, Lv Y, Guo M, Zhou W, Chen C, Gao C, Zhang BY, Dong XP. Reduction of NF-κB (p65) in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents. ACS Chem Neurosci. 2017 Nov 15;8(11):2535-2548. 11. Chen C, Xu XF, Zhang RQ, Ma Y, Lv Y, Li JL, Shi Q, Xiao K, Sun J, Yang XD, Shi Q, Dong XP. Remarkable increases of α1-antichymotrypsin in brain tissues of rodents during prion infection. Prion, 12. Shi Q, Zhou W, Chen C, Xiao K, Wang Y, Gao C, Dong XP. Rare genetic Creutzfeldt-Jakob disease with T188K mutation: analysis of clinical, genetic and laboratory features of thirty Chinese patients. J Neurol Neurosurg Ps, doi: 10.1136/jnnp-2016-314868 13. Shi Q, Chen LN, Lv Y, Zhang BY, Xiao K, Zhou W, Chen C, Sun J, Yang XD, Dong XP. Comparative proteomics analyses for 139A and ME7 scrapie infected mice brains in the middle and terminal stages. Proteom Clin Appl, doi: 10.1002/prca.201600113 14. Wang H, Tian C, Sun J, Chen LN, Lv Y, Yang XD, Xiao K, Wang J, Chen C, Shi Q, Shao QX, Dong XP. Overexpression of PLK3 mediates the degradation of abnormal prion proteins dependent on chaperone-mediated autophagy. Mol Neurobiol, DOI: 10.1007/s12035-016-9985-0 15. Shi Q, Sun H, Chen C, Zhang BY, Zhou W, Gao C, Dong XP. Treatment of redox process induces diverse effects on the recombinant human wild-type PrP and the mutated PrP with inserted or deleted octarepeats. Int J Mol Med, (accepted) 16. Gao C, Han J, Zhang J, Wei J, Zhang BY, Tian C, Zhang J, Shi Q, Dong XP. Protein misfolding cyclic amplification cross-species products of mouse-adapted scrapie strain 139A and hamster-adapted scrapie strain 263K with brain and muscle tissues of opposite animals generate infectious prions. Mol Neurobiol, 2017, 54:3771-3782 17. Guo YJ, Shi Q, Yang XD, Li JL, Ma Y, Xiao K, Chen C, Dong XP, Increases of Galectin-1 and its S-nitrosylated form in the brain tissues of scrapie infected rodent models and human prion diseases. Mol Neurobiol, 2017, 54:3707-3716 18. Shi Q, Xiao K, Chen C, Zhou W, Gao C, Wang J, Zhang BY, Wang Y, Zhang F, Dong XP. Clinical and laboratory features of 14 young Chinese probable sCJD patients. Prion, 2017, 11:128-135. 19. Chen LN, Sun J, Yang XD, Xiao K, Lv Y, Zhang BY, Zhou W, Chen C, Gao C, Shi Q, Dong XP. The brain NO levels and NOS activities ascended in the early and middle stage and descended in the terminal stage in scrapie infected animal models. Mol Neurobiol, 2017, 54:1786-1796. 20. Yang XD, Shi Q, Sun J, Lv Y, Ma Y, Chen C, Xiao K, Zhou W, Dong XP. Aberrant alterations of mitochondrial factors Drp1 and Opa1 in the brains of scrapie experiment rodents. J Mol Neurosci, 2017, 61:368-378.

学术兼职

中国微生物学会理事、中国微生物学会病毒学委员会医学病毒组组长、中华预防医学会理事、中国全球病毒网络(GVN)副主席、传染病标委会副主任委员和10多个国家及部委的专业委员会常务委员、委员。担任10余个英文和中文杂志的副主编及编委

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