个人简介
招生专业
071010-生物化学与分子生物学
100701-药物化学
招生方向
天然产物化学
教育背景
1986-09--1989-07 中国科学院昆明植物研究所 理学硕士
1978-09--1982-06 西北师范大学 理学学士
教授课程
植物与人类健康和社会发展
有机结构分析
科学通识课:科研论文写作(微观领域)
天然产物化学
专利
1.吴萍; 魏孝义; 姚磊; 薛璟花. 一类Peptaibol抗菌肽化合物及其制备方法和应用. 中国专利, 授权, 2016, 专利号:CN201610058220.9。
2. 吴 萍、史敬芳、蒋子华、魏孝义,番荔枝内酯衍生物及其制备方法和用途,2015.4,中国,ZL201210040071.5。
3. 徐良雄,魏孝义,薛璟花,吴萍,莫纳西林类β-雷琐酸大环内酯在血吸虫病防治中的用途,2014.9, 中国,201210094426.9。
4. 徐良雄,段学武,魏孝义,薛璟花,吴萍,一种大环内酯化合物在植物霜霉病防治中的应用,2014.8, 中国,ZL201310277076.4。
5. 徐良雄,魏孝义,薛璟花,吴萍,游晓莹,一种β-间二羟基苯甲酸大环内酯衍生物在有害螺类防治中的应用,2013.3, 中国,ZL201110207371.3。
6. 徐良雄,魏孝义,薛璟花,吴萍,游晓莹,β-雷琐酸大环内酯在有害螺类防治中的用途,2013.1, 中国,L201110207375.1。
科研项目
( 1 ) 鼎湖山自然保护区真菌抗细菌代谢产物的研究, 主持, 国家级, 2012-01--2015-12
( 2 ) 抗肿瘤番荔枝内酯受体介导衍生物的合成及其靶向输送作用, 主持, 国家级, 2015-01--2018-12
( 3 ) 特色植物资源利用、保鲜及作物遗传改良新技术, 主持, 部委级, 2015-07--2017-06
( 4 ) 五种蕨类植物的内生真菌抗MRSA活性代谢产物的研究, 主持, 国家级, 2019-01--2022-12
参与会议
(1)枝顶孢属真菌Acremine类代谢产物 中国化学会第12届全国天然有机化学学术会议 2018-07-28
(2)鼎湖山来源真菌生物活性代谢产物的研究 中国化学会第31届学术年会 2018-04-04
(3)Four cyclodepesipeptide chymotrypsin inhibitors from soil-derived Streptomyces sp. SC0581 中国化学会第十一届全国天然有机化学学术会议 2016-09-26
(4)溶杆菌PTM代谢产物绝对构型的归属 第五届岭南有机化学论坛 魏孝义 2015-12-04
(5)理论计算在天然产物手性光学特性分析中的应用 第五届中国科学院超级计算应用大会 魏孝义 2015-10-09
(6)Configurations of HSAF and Analogues 第二届溶杆菌学术论坛 魏孝义 2015-07-18
(7)一株Acremonium真菌的抗菌肽和Acremine类代谢产物 中国化学会第十届全国天然有机化学学术会议 吴萍 姚磊 薛璟花 魏孝义 2014-11-21
获奖
(1) 鱼藤酮生物农药产业体系的构建及关键技术集成,二等奖,国家科技进步二等奖,第二完成单位,2010
(2) 鱼藤酮资源植物与鱼藤酮生物农药的研究应用,二等奖,省级,2008
合作情况
与日本丸善制药株式会社合作进行中国甘草资源保护与可持续利用研究
与美国University of Nebraska−Lincoln化学系合作进行次生代谢产物生物合成研究
与美国University of Arizona资源与环境学院合作进行真菌次生代谢产物生物合成研究
与加拿大Lakehead University化学系合物进行生物活性天然产物结构修饰研究
近期论文
查看导师新发文章
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(1) Dinghupeptins A−D, Chymotrypsin Inhibitory Cyclodepsipeptides Produced by a Soil-Derived Streptomyces., Journal of Natural Products, 2018, 通讯作者
(2) Methylglucosylation of aromatic amino and phenolic moieties of drug-like biosynthons by combinatorial biosynthesis, Methylglucosylation of aromatic amino and phenolic moieties of drug-like biosynthons by combinatorial biosynthesis, PNAS, 2018, 其他(合作组作者)
(3) Antifungal and Cytotoxic β‑Resorcylic Acid Lactones from a Paecilomyces Species, Antifungal and Cytotoxic β‑Resorcylic Acid Lactones from a Paecilomyces Species, Journal of Natural Products, 2017, 通讯作者
(4) Synthesis, cytotoxic activity and drug combination study of tertiary amine derivatives of 20,40- dihydroxyl-60-methoxyl-30,50-dimethylchalcone, Synthesis, cytotoxic activity and drug combination study of tertiary amine derivatives of 20,40- dihydroxyl-60-methoxyl-30,50-dimethylchalcone, RSC Advances, 2017, 通讯作者
(5) Cycloheximide congeners produced by Streptomyces sp. SC0581 and photoinduced interconversion between (E)- and (Z)-2,3-dehydroanhydrocycloheximides, Beilstein Journal of Organic Chemistry, 2017, 通讯作者
(6) Two new 2,5-diketopiperazines produced by Streptomyces sp. SC0581, Phytochemistry Letters, 2017, 通讯作者
(7) Non-flavonoid phenolics from Averrhoa carambola fresh fruit, Journal of Functional Foods, 2017, 第 5 作者
(8) Phenolics from strawberry cv. Falandi and their antioxidant and alpha-glucosidase inhibitory activities, Food Chemistry, 2016, 第 4 作者
(9) Spiro Meroterpenoids from Ganoderma applanatum, Journal of Natural Products, 2016, 第 2 作者
(10) Bioactive Pentacyclic Triterpenoids from the Leaves of Cleistocalyx operculatus, Journal of Natural Products, 2016, 通讯作者
(11) Chrysamides A−C, Three Dimeric Nitrophenyl trans-Epoxyamides Produced by the Deep-Sea-Derived Fungus Penicillium chrysogenum SCSIO41001, Organic Letters, 2016, 第 5 作者
(12) Norsesquiterpenoids and triterpenoids from strawberry cv. Falandi, Food Chemistry, 2016, 第 4 作者
(13) Synthesis and cancer cell growth inhibitory activity of icaritin derivatives, Eur. J. Med. Chem., 2015, 通讯作者
(14) Bioactive Polycyclic Tetramate Macrolactams from Lysobacter enzymogenes and Their Absolute Configurations by Theoretical ECD Calculations, J. Nat. Prod., 2015, 通讯作者
(15) Bisacremines A-D, Dimeric Acremines Produced by a Soil-Derived Acremonium persicinum Strain, J. Nat. Prod., 2015, 通讯作者
(16) Bisacremines E-G, Three Polycyclic Dimeric Acremines Produced by Acremonium persicinum SC0105., Organic Letters, 2015, 通讯作者
(17) Arthpyrones A-C, Pyridone Alkaloids from a Sponge-Derived Fungus Arthrinium arundinis ZSDS1-F3, Organic Letters, 2015, 第 2 作者
(18) New glucosidated pyrazinoquinazoline indole alkaloids from fungus Aspergillus fumigatus derived of a jellyfish, Tetrahedron, 2015, 第 2 作者
(19) Cytotoxic and Antibacterial Quinone Sesquiterpenes from a Myrothecium Fungus, J. Nat. Prod., 2014, 通讯作者
(20) Penicillitone, a Potent in Vitro Anti-inflammatory and Cytotoxic Rearranged Sterol with an Unusual Tetracycle Core Produced by Penicillium purpurogenum., organic letters, 2014, 通讯作者
(21) Synthesis and tumor cell growth inhibitory activity of biotinylated annonaceous acetogenins. , Eur. J. Med. Chem., 2014, 通讯作者
(22) Anti-inflammatory cyclopeptides from exocarps of sugar-apples., Food Chemistry, 2014, 通讯作者
(23) Absolute configurations of four resorcylic acid lactones, paecilomycins J-M, CD/TDDFT calculations., Chirality, 2014, 通讯作者
(24) Guignardins AeF, spirodioxynaphthalenes from the endophytic fungus Guignardia sp. KcF8 as a new class of PTP1B and SIRT1 inhibitors, Tetrahedron, 2014, 第 2 作者
(25) Sinulolides A–H, New Cyclopentenone and Butenolide Derivatives from Soft Coral Sinularia sp., Mar. Drugs, 2014, 第 2 作者
(26) Abietane diterpenoids from Isodon lophanthoides var. graciliflorus and their cytotoxicity, Food Chemistry, 2013, 第 4 作者
(27) Paecilomycins J–M, four new b-resorcylic acid lactones from Paecilomyces sp. SC0924, Tetrahedron Letters, 2013, 通讯作者
(28) Flavonoids from the capitula of Eriocaulon australe, Food Chemistry, 2013, 第 4 作者
(29) Phenolic Constituents from the Roots of Mikania micrantha and Their Allelopathic Effects, J. Agric. Food Chem. , 2013, 第 4 作者
(30) Podocarpane, isopimarane, and abietane diterpenoids from Isodon lophanthoides var. graciliflorus, Food Chemistry, 2013, 通讯作者
(31) Antifungal activity of hypothemycin against Peronophythora Litchii in Vitro And in Vivo., J. Agric. Food Chem., 2013, 通讯作者
(32) Resin glycosides from the aerial parts of Operculina turpethum, Phytochemistry, 2012, 通讯作者
(33) Monocillin II Inhibits Human Breast Cancer Growth Partially by Inhibiting MAPK Pathways and CDK2 Thr160 Phosphorylation, ChemBioChem, 2012, 通讯作者
(34) Three new ?-resorcylic acid lactones from Paecilomyces sp SC0924, Chinese J. Chem., 2012, 通讯作者
(35) Further sesquiterpenes from the mycelia cultures of Dichomitus squalens, Helv. Chim. Acta, 2011, 通讯作者
(36) Bioactive Dammarane-Type Saponins from Operculina turpethum, J. Nat. Prod., 2011, 通讯作者
(37) Three New 3,6-Dioxygenated Diketopiperazines from the Basidiomycete Lepista sordida, Helv. Chim. Acta , 2011, 通讯作者
(38) Monoterpenoid Indole Alkaloids Mediating DNA Strand Scission from Turpinia arguta, Planta Med., 2011, 通讯作者
(39) Antioxidant Phenolic Compounds of Cassava (Manihot esculenta) from Hainan, Molecules, 2011, 通讯作者
(40) beta-Resorcylic acid lactones from a Paecilomyces Fungus, J. Nat. Prod., 2010, 通讯作者
(41) Phytoecdysteroids from the rhizomes of Brainea insignis, Phytochemistry, 2010, 通讯作者
(42) The first cyclic phenolic acid glycoside dimer and new alpha-tetralone and triterpenoid glucosides from Gentiana loureirii, Chem. Pharm. Bull., 2010, 通讯作者
(43) A new coumarin from Sarcandra glabra, Fitoterapia, 2010, 通讯作者
(44) Iridoids from Gentiana loureirii, Phytochemistry, 2009, 通讯作者
(45) Polyoxygenated methyl cyclohexanoids from a terrestrial Ampelomyces fungus, J. Nat. Prod., 2009, 通讯作者
(46) Polyphenols from longan seeds and their radical-scavenging activity, Food Chem., 2009, 通讯作者
(47) Prenylflavonols from the leaves of Macaranga sampsonii, Chem. Pharm. Bull., 2009, 通讯作者
(48) Sesquiterpenes and Lignans from Tephrosia vogelii, Helv. Chim. Acta, 2009, 通讯作者