Zuckerman, Ron - Stony Brook University

个人简介

Ronald Zuckermann received his B.S. in Chemistry in 1984 from Harvey Mudd College where he did undergraduate research in synthetic organic chemistry. He then went on to UC Berkeley to study Bioorganic Chemistry with Dr. Peter Schultz. His thesis work was on the synthesis of semi-synthetic nucleases capable of the sequence-specific cleavage of RNA. After receiving the first Schultz group Ph.D. in 1989, he became one of the founding chemists at Protos Corp., a combinatorial drug discovery start-up in Emeryville, CA. There he helped develop several key drug discovery technologies such as robotic combinatorial library synthesizers, affinity selection methods and a novel class of heteropolymers called "Peptoids". Chiron Corp. acquired Protos in 1991 where this work continued and was applied to small molecule drug discovery, new biomaterials and DNA delivery. Dr. Zuckermann was promoted to Research Fellow in 2003. In early 2006, he left Chiron to join the Lawrence Berkeley National Laboratory, where he is currently Facility Director of the Biological Nanostructures Facility at The Molecular Foundry. There he is expanding the application of peptoid polymers to mimic the structure and function of proteins, by folding peptoid chains into defined nanoarchitectures. He was promoted to Senior Scientist in 2011. He has published over 115 papers and is co-inventor on 38 patents.

研究领域

Molecular biomimicry with peptoid polymers. Atomically-defined soft nanostructured materials. Methods and technologies for rapid combinatorial discovery. Materials science applications of sequence-specific heteropolymers. Design and synthesis of functional artificial proteins.

近期论文

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Modeling Sequence-Specific Polymers Using Anisotropic Coarse-Grained Sites Allows Quantitative Comparison with Experiment. Haxton, T.K.; Mannige, R.V.; Zuckermann, R.N.; Whitelam, S.W., J. Chem. Theory Comput., 11, 303-315 (2015). http://pubs.acs.org/doi/abs/10.1021/ct5010559 Structure-Determining Step in the Hierarchical Assembly of Peptoid Nanosheets. Sanii, B.; Haxton, T.K.; Olivier, G.K.; Cho, A.; Barton, B.; Proulx, C.; Whitelam, S.; Zuckermann, R.N., ACS Nano, 8, 11674-11684 (2014). http://pubs.acs.org/doi/abs/10.1021/nn505007u Morphology-Conductivity Relationship in Crystalline and Amorphous Sequence-Defined Peptoid Block Copolymer Electrolytes. Sun, J.; Liao, X.; Minor, A.M.; Balsara, N.P.; Zuckermann, R.N., J. Am. Chem. Soc., 136, 14990-14997 (2014). http://pubs.acs.org/doi/abs/10.1021/ja5080689 Precision sequence control in bioinspired peptoid polymers. Sun, J.; Proulx, C.; Zuckermann, R.N., In Sequence-Controlled Polymers: Synthesis, Self-Assembly, and Properties; ACS Symposium Series, Francois-Lutz, J., Ed. 1170, 25-53 (2014). http://pubs.acs.org/doi/abs/10.1021/bk-2014-1170.ch003 Assembly and molecular order of two-dimensional peptoid nanosheets through the oil–water interface. Robertson, E.J.; Olivier, G.K.; Qian, M.; Proulx, C.; Zuckermann, R.N.; Richmond, G.L., Proc. Natl. Acad. Sci. U.S.A., 111, 13284–13289 (2014). LBNL press release: "Peptoid Nanosheets at the Oil/Water Interface" U. Oregon story: "New nano-sized scaffolding technique" JSTO in the News: "Oil and Water is the Right Mix for Better Chem-Bio Detection" Tuning calcite morphology and growth acceleration by a rational design of highly stable protein-mimetics. Chen, C.-L.; Qi, J.; Tao, J.; Zuckermann, R.N.; DeYoreo, J.J., Sci. Reports, in press (2014). http://www.nature.com/srep/2014/140905/srep06266/full/srep06266.html "Inspired by Nature, Scientists Design Protein-esque Molecules to Lock Up Carbon Dioxide" Matching 4.7-Å XRD spacing in Amelogenin Nanoribbons and Enamel Matrix. Sanii, B.; Martinex-Avila, O.; Simpliciano, C.; Zuckermann, R.N.; Habelitz, S., J. Dent. Res., 93, 918-922 (2014). http://jdr.sagepub.com/content/93/9/918 Sequence of Hydrophobic and Hydrophilic Residues in Amphiphilic Polymer Coatings Affects Surface Structure and Marine Antifouling/Fouling Release Properties. van Zoelen, W.; Buss, H.G.; Ellebracht, N.C.; Lynd, N.A.; Fischer, D.A.; Finlay, J.; Hill, S.; Callow, M.E.; Callow, J.A.; Kramer, E.J.; Zuckermann, R.N.; Segalman, R.A., ACS Macro Letters, 3, 364 (2014). http://pubs.acs.org/doi/abs/10.1021/mz500090n Nanometer-scale siRNA carriers incorporating peptidomimetic oligomers: physical characterization and biological activity. Konca, Y.U.; Kirshenbaum, K.; Zuckermann, R.N., Int. J. Nanomed., 9, 2271 (2014). http://dx.doi.org/10.2147/IJN.S57449 Development and Use of an Atomistic CHARMM-Based Forcefield for Peptoid Simulation. Mirijanian, D.T.; Mannige, R.V.; Zuckermann, R.N.; Whitelam, S., J. Comput. Chem., 35, 360-370 (2014). http://dx.doi.org/10.1002/jcc.23478 Crystallization in Sequence-Defined Peptoid Diblock Copolymers Induced by Microphase Separation. Sun, J.; Teran, A.A.; Liao, X.; Balsara, N.P.; Zuckermann, R.N., J. Am. Chem. Soc., 136, 2070-2077 (2014). http://dx.doi.org/10.1021/ja412123y