刘将新 - 中国科学院昆明植物研究所 -

个人简介

2003-09--2008-07 中国科学技术大学博士 1999-09--2003-06 四川大学学士

研究领域

1. 活性天然产物新靶点的鉴定和确证 2. 基于药物靶点和核磁共振技术NMR的活性天然产物筛选 3. 活性天然产物的成药性评价

近期论文

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Liu, Jiangxin, Ren, Jian, Yang, Kun, Chen, Shuang, Yang, Xinni, Zhao, Qin-Shi*. Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase. European Journal of Medicinal Chemistry, 2022, 235:114294. Liu, Jiangxin; Wu, Xing-De; Li, Wenyan; Yuan, Zaifeng; Yang, Kun; Zhao, Qin-Shi*; Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism. Bioorganic Chemistry, 2021, 112: 104963 Bi, Ran; Yang, Xinni; Zhou, Haofeng; Peng Liyan; Liu, Jiangxin*; Zhao Qin-Shi*. Eleven undescribed alkaloids from the rhizomes of Sinomenium acutum and their IDO1 and TDO inhibitory activities. Phytochemistry, 2022, 200: 113244 Yang Emily #, Yoo Chan #, Liu Jiangxin#, Wang He, Cao Jun, Li Fay-Wei, Pryer Kathleen M., Sun Tai-ping, Weigel Detlef, Zhou Pei*, Chen Meng*. NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches. Nature Communications, 2019, 10:2630 (共第一作者) Nuan Ning, Zhao Qiyu, Duan Zilei, Ji Mengyao, Xing Meichen, Zhu Tengyu, Mwangi James, Rong Mingqiang*, Liu Jiangxin*, Lai Ren*. Identification and Characterization of ShSPI, a Kazal-Type Elastase Inhibitor from the Venom of Scolopendra Hainanum. Toxins, 2019, 11(12): 0-708. Rong, Mingqiang#; Liu, Jiangxin#; Zhang, Meilin#; Wang, Gan; Zhao,Gang; Wang, Guodong; Zhang, Yaping; Hu, Kaifeng*; Lai, Ren*. A sodium channel inhibitor ISTX-I with a novel structure provides a new hint at the evolutionary link between two toxin folds. Scientific Reports, 2016, 6:29691 (共第一作者) Shao, Li-Dong#; Su, Jia#; Ye, Baixin#; Liu, Jiang-Xin#; Zuo, Zhi-Li, Li, Yan; Wang, Yue-Ying*; Xia, Chengfeng*; Zhao, Qin-Shi*. Design, Synthesis, and Biological Activities of Vibsanin B Derivatives:A New Class of HSP90 C‑Terminal Inhibitors. Journal of Medicinal Chemistry. 2017, 60, 9053-9066 (共第一作者) Liu, Jiangxin; Fan, Shilong; Lee, Chul-Jin; Arno, L Greenleaf; Zhou, Pei*. Specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the carboxyl-terminal domain repeat. The Journal of Biological Chemistry, 2013, 288:10890-10901 Wojtaszek, Jessica#; Liu, Jiangxin#; Souza, Sanjay#; Wang, Su; Xue, yaohua; Walker, Graham C; Zhou, Pei*. Multifaceted recognition of vertebrate Rev1 by translesion polymerases zeta and kappa. The Journal of Biological Chemistry, 2013,287: 26400-26408 (共第一作者) Liu, Jiangxin; Zhang, Jiahai; Yang, Yinshan; Huang, Hongda; Shen, Weiqun; Hu, Qi; Wang, Xingsheng; Wu, Jihui; Shi, Yunyu, Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor. Protein Science, 2008.17(6): 1003~1014