熊文勇 - 中国科学院昆明植物研究所 -

个人简介

1995年9月-1999年7月，陕西师范大学，学士 1999年9月-2004年7月，中国科学院昆明动物研究所，博士 2004年9 月-2007年7月，美国南加州大学医学院 (University of Southern California) ，博士后 2007年7月-2010年 12 月，美国康乃尔大学医学院（Cornell University），博士后 2010年12月-至今，中国科学院昆明植物研究所，植物化学与西部植物资源持续利用国家重点实验室，研究员

研究领域

治疗2型糖尿病和肥胖的药物活性筛选及作用机制研究治疗2型糖尿病天然药物研发脂肪细胞生成的调控胰岛素受体信号通路调控的GLUT4膜转运

近期论文

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Qiuyan Yan, Yanting Lu, Lulu Zhou, Junling Chen, Haijiao Xu, Mingjun Cai, Yan Shi, Junguang Jiang, Wenyong Xiong*, Jing Gao,* Hongda Wang*. Mechanistic insights into GLUT1 activating and clustering revealed by super-resolution imaging. Proc Natl Acad Sci U S A. 2018, 1803859115. Yangang Pan#, Yuebin Zhang#, Pianchou Gongpan#, Bin Wang, Bingqian Xu, Yuping Shan*, Wenyong Xiong*, Guohui Li* and Hongda Wang*. Single molecule glucose transporting process revealed by force tracing and molecular dynamics simulations. Nanoscale Horizons. 2018, C8NH00056E. Yanfen Niu, Yuanfang Zhou, Hua Lin, Li-Hui Gao, Wenyong Xiong, Huajie Zhu, Cheng-Gang Zou*, Ling Li*. Inhibition of 3,5,2',4'-tetrahydroxychalcone on production of uric acid in hypoxanthine-induced hyperuricemic mice. Biological Pharmaceutical Bulletin. 2018, 41(1): 99-105. Yanfen Niu, Hongjian Li, Lihui Gao, Hua Lin, Hsiangfu Kung, Marie Chia-mi Lin , Kwong-Sak Leung , Man-Hon Wong, Wenyong Xiong*, Ling Li*. Old Drug, New Indication: Olsalazine Sodium Reduced Serum Uric Acid Levels in Mice via Inhibiting Xanthine Oxidoreductase Activity. Journal of Pharmacological Sciences. 2017, 135(3):134-120. Yuhui Xu, Yanfen Niu, Yuan Gao, Fang Wang, Wanying Qin, Yanting Lu, Jing Hu, Li Peng, Jikai Liu*, and Wenyong Xiong*. Borapetoside E, a Clerodane Diterpenoid Extracted from Tinospora crispa, Improves Hyperglycemia and Hyperlipidemia in High-Fat-Diet-Induced Type 2 Diabetes Mice. Journal of Natural Products. 2017, 80:2319？2327. Li Peng, Yanting Lu, Yuhui Xu, Jing Hu, Fang Wang, Wanying Qin, Yumei Zhang*, Wenyong Xiong*. Pyrocincholic Acid 3β-O-β-D-quinovopyranosyl-28-O-β-D-glucopyranoside Suppresses Adipogenesis and Regulates Lipid Metabolism in 3T3-L1 Adipocytes. Natural Products and Bioprospecting. 2017, 7(3):225-234. Lan Gao, Junling Chen, Jing Gao, Hongda Wang*, Wenyong Xiong*. Super-resolution microscopy reveals the reorganization of GLUT4 on plasma membrane regulated by insulin resistance. Journal of Cell Science. 2017, 130: 396-405. Yuan Gao#, Yan-Fen Niu#, Fei Wang, Ping Hai, Fang Wang, Yin Dong, Wen-Yong Xiong*, Ji-Kai Liu*. Clerodane Diterpenoids with Anti-hyperglycemic Activity from Tinospora crispa. Natural Products and Bioprospecting. 2016, 6(5):247-255. Qinghua Kong#, Lan Gao#, Yanfen Niu, Pianchou Gongpan, Yuhui Xu, Yan Li*, Wenyong Xiong*. RACK1 is required for adipogenesis. American Journal of Physiology-Cell Physiology. 2016, 311(5): C831-C836. Junling Chen, Tianzhou, Liu, Jing Gao, Lan Gao, Lulu Zhou, Mingjun Cai, Yan Shi, Wenyong Xiong, Junguang Jiang, Ti Tong*, Hongda Wang*. Variation in carbohydrates between Cancer and Normal Cell Membranes Revealed by Super-Resolution Fluorescence Imaging. Advanced Science (Weinh). 2016, 3(12):1600270. Pianchou Gongpan, Yanting Lu, Fang Wang, Yuhui Xu & Wenyong Xiong*. AS160 controls eukaryotic cell cycle and proliferation by regulating the CDK inhibitor p21. Cell Cycle. 2016, 15(13):1733-41. Li-Wen Tian, Mu-Ke Tao, Min Xu, Jing Hu, Hong-Tao Zhu, Wen-Yong Xiong, Dong Wang, Chong-Ren Yang, Ying-Jun Zhang*. Carboxymethyl- and Carboxyl-Catechins from Ripe Pu-er Tea. Journal of Agricultural and Food Chemistry, 2014, 62(50), 12229-12234. L. Amanda Sadacca, Joanne Bruno, Jennifer Wen, Wenyong Xiong, and Timothy E. McGraw*. Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs. Molecular Biology of the Cell. 2013, 24(16): 2544-2557. Wenyong Xiong, Ingrid Jordens, Eva Gonzalez and Timothy McGraw*. GLUT4 is sorted into vesicles whose accumulation beneath and insertion to the plasma membrane is differentially regulated by insulin and selectively by insulin resistance. Molecular Biology of the Cell. 2010, 21(8):1375-1386. Ingrid Jordens, Dorothee Molle#, Wenyong Xiong# and Timothy McGraw*. IRAP is a key regulator of GLUT4 trafficking by controlling sorting from endosomes to specialized insulin-regulated vesicles. Molecular Biology of the Cell. 2010, 21(12):2034-2044. Darren J Michael#, Wenyong Xiong# (#equal contribution), Xuehui Geng, Peter Drain and Robert H Chow*. Human Insulin Vesicle Dynamics During Pulsatile Secretion. Diabetes. 2007, 56(5):1277-1288. Peter Pyrko, Adel Kardosh, Weijun Wang, Wenyong Xiong, Axel H Sch？nthal, and Thomas C Chen*. HIV-1 protease inhibitors nelfinavir and atazanavir induce malignant glioma death by triggering endoplasmic reticulum stress. Cancer Research. 2007, 67(22):10920-10928. Peter Pyrko, Adel Kardosh, Yen-Ting Liu, Nathaniel Soriano, Wenyong Xiong, Robert H Chow, Jasim Uddin, Nicos A Petasis, Austin K Mircheff, Robert A Farley, Stan G Louie, Thomas C Chen, Axel H Sch？nthal*. Calcium-induced ER stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib (DMC), a non-coxib derivative of celecoxib. Molecular Cancer Theraputics. 2007, 6(4):1262-1275. Darren J Michael, Haijiang Cai, Wenyong Xiong, Justin Ouyang and Robert H Chow*. Mechanisms of peptide hormone secretion. TRENDS in Endocrinology and Metabolism. 2006, 17(10):408-415.