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个人简介

1991-1995,山东大学,生物学学士 1995-1998,山东大学,细胞生物学硕士 1998-2001,山东大学,德国癌症研究中心合作培养,分子发育生物学博士 2001-2003,德国国家癌症研究中心(DKFZ),博士后 2003-2007,美国辛辛那提儿童医院医学中心(CCHMC),博士后 2008 -至今,中科院昆明植物研究所,植物化学与西部植物资源持续利用国家重点实验室,肿瘤药物药理学及化学生物学课题组组长,研究员,博导

研究领域

主要从事抗肿瘤活性化合物筛选、活性评价和机制研究,以及与肿瘤和肿瘤干细胞密切相关的重要信号通路的化学生物学研究。目前研究组已经建立了较为完备的活性化合物筛选、作用机理研究以及抗肿瘤活性评价平台

近期论文

查看导师新发文章 (温馨提示:请注意重名现象,建议点开原文通过作者单位确认)

1. An, Tao, Gong, Yaxiao, Li, Xue, Kong, Lingmei, Ma, Pengcheng, Gong, Liang, Zhu, Huifang, Yu, Chunlei, Liu, Jianmei, Zhou, Hongyu, Mao, Bingyu, Li, Yan*. USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth. Biochemical Pharmacology, 2017.02.11. 2. Yu, Chunlei, Gong, Yaxiao, Zhou, Hongyu, Wang, Min, Kong, Lingmei, Liu, Jianmei, An, Tao, Zhu, Huifang, Li, Yan*. Star-PAP, a poly(A) polymerase, functions as a tumor suppressor in an orthotopic humanbreast cancer model. Cell Death & Disease, 2017.2.2, 8 (2): e2582. 3. Zhou H, Shang C, Wang M, Shen T, Kong L, Yu C, Ye Z, Luo Y, Liu L, Li Y, Huang S.2016, Ciclopirox olamine inhibits mTORC1 signaling by activation of AMPK. Biochemical Pharmacology [Epub ahead of print] 4. Kong LM, Feng T, Wang YY, Li XY, Ye ZN, An T, Qing C, Luo XD, Li Y. 2016, Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling. Oncotarget 1;7(9):10203-14 5. Li X , Bai B, Liu L, Ma P, Kong L, Yan J, Zhang J, Ye Z, Zhou H, Mao B , Zhu H and Li Y .2015, Novel β-Carbolines Against Colorectal Cancer Cell Growth Via Inhibition of Wnt/β-catenin signaling. Cell Death & Discovery 1, 15033 6. Kong L, Mao B, Zhu H and Li Y .2015, Novel β-carbolines inhibit Wnt/β-catenin signaling. Cell Death & Disease ,6, e1983 7.Ye ZN, Yu MY, Kong LM, Wang WH, Yang YF, Liu JQ, Qiu MH, Li Y. 2015, Biflavone Ginkgetin, a Novel Wnt Inhibitor, Suppresses the Growth of Medulloblastoma. Natural Products and Bioprospecting . 2015 April; 5(2): 91–97 8. Ma P, Yang X, Kong Q, Li C, Yang S, Li Y, Mao B. 2014,The Ubiquitin Ligase RNF220 Enhances Canonical Wnt Signaling through USP7-Mediated Deubiquitination of β-Catenin. Mol Cell Biol, 34(23):4355-66 9. Zhou H, Shen T, Shang C, Lou Y, Liu L, Yan J, Li Y,Huang S. 2014, Ciclopirox induces autophagy through reactive oxygen species-mediated activation of JNK signaling pathway. Oncotarget, 30;5(20):10140-50. 10. Kong LM, DengX, Zuo ZL, Sun HD, Zhao QS, Li Y. 2014,Identification and validation of p50 as the cellular target of eriocalyxin B.Oncotarget , Nov 30;5(22):11354-64 11.Zhang J, Kong LM, Zhan R, Ye ZN, Pu JX, Sun HD, Li Y.2014,Two Natural ent-kauranoids as Novel Wnt Signaling Inhibitors. Natural Products and Bioprospecting, 2014, 4:135–140 12. Liu W, Su J, Jiang J, Li X, Ye Q, Zhou H, Chen J, Li Y, 2013, Two mixed-NH3/amine platinum (II) anticancer complexes featuring a dichloroacetate moiety in the leaving group, Scientific Reports, 3 : 2464. 13. Li X, Pu J, Jiang S, Su J, Kong L, Mao B, Sun H, Li Y, 2013, Henryin, an ent-kaurane Diterpenoid, Inhibits Wnt Signaling through Interference with β-Catenin/TCF4 Interaction in Colorectal Cancer Cells. PLoS One, 8(7):e68525. 14.Su J, Zhao P, Kong L, Li X, Yan J, Zeng Y, Li Y, 2013, Trichothecin Induces Cell Death in NF-κB Constitutively Activated Human Cancer Cells via Inhibition of IKKβ Phosphorylation, PLoS One , 8(8):e71333. 15.Yan J, Zhou H, Kong L, Zhang J, Zhao Q, Li Y, 2013, Identification of two novel inhibitors of mTOR signaling pathway based on high content screening, Cancer Chemother Pharmacol, 72(4): 799-808. 16. Zhao Y, Su J, Goto M, Morris-Natschke SL, Li Y, Zhao QS, Yao ZJ, Lee KH, 2013, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation. J Med Chem, 56(11):4749-57. 17. Li XY, Wang YY, Yuan CM, Hao XJ, Li Y, 2013, A reporter gene system for screening inhibitors of Wnt signaling pathway. Natural Products and Bioprospecting, 3, pp24-28. 18. Li Y, Rankin SA, Sinner D, Kenny AP, Krieg PA, Zorn AM, 2008, Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling, Genes Dev, 22(21), pp3050-63. 19. Mao B, Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C, 2001, LDL-receptor-related protein 6 is a receptor for Dickkopf proteins, Nature, 411(6835), pp321-5

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