赵勤实 - 中国科学院昆明植物研究所 -

个人简介

赵勤实，博士，二级研究员，博士生导师，中国科学院特聘研究员，享受云南省政府特殊津贴。1993-1995年，中国科学院昆明植物研究所植物化学专业，理学博士；1995-1998年，军事医学科学院毒物研究所博士后；1998年至今在中国科学院昆明植物研究所工作，期间先后在日本静冈县立大学和美国伊利诺伊大学芝加哥药学院做访问学者。现任植物化学与西部植物资源持续利用国家重点实验室副主任、云南省天然药物化学重点室副主任，研究所学术委员会委员。国家药审中心新药审评专家，云南省科学技术一等奖获得者（2003），国际SCI期刊《Chemistry & Biodiversity》编委会主席，蕨类植物协会副理事长。曾兼任研究所公共技术服务中心主任，广西功能物质研究与开发重点实验室学术委员会主任

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1. Xu, J.; Shao, L.-D.; Li, D.; Deng, X.; Liu, Y.-C.; Zhao, Q.-S.*; Xia, C.-F.*, Construction of tetracyclic 3-spirooxindole through cross-dehydrogenation of pyridinium: applications in facile synthesis of (±)-corynoxine and (±)-corynoxine B. Journal of the American Chemical Society, 2014, 136, 17962-17965. 2. Yu, Z.-Y.; Xiao, H.; Wang, L.-M.; Shen, X.; Jing, Y.; Wang, L.; Sun, W.-F.; Zhang, Y.-F.; Cui, Y.; Shan, Y.-J.; Zhou, W.-B.; Xing, S.; Xiong, G.-L.; Liu, X.-L.; Dong, B.; Feng, J.-N.; Wang, L.-S.; Luo, Q.-L.; Zhao, Q.-S.*; Cong, Y.-W.*, Natural product vibsanin A induces differentiation of myeloid leukemia cells through PKC activation. Cancer Research, 2016, 76, 2698-2709. 3. Shao, L.-D.; Su, J.; Ye, B.-X.; Liu, J.-X.; Zuo, Z.-L.; Wang, Y.-Y.*; Xia, C.-F.*; Zhao, Q.-S.*, Design, synthesis, and biological activities of vibsanin B derivatives: a new class of HSP90 C-terminal inhibitors. Journal of Medicinal Chemistry, 2017, 60, 9053-9066. 4. Zhao, Y.; Su, J.; Goto, M.; Morris-Natschke, S. L.; Li, Y.; Zhao, Q.-S.*; Yao, Z.-J.*; Lee, K.-H.*, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation. Journal of Medicinal Chemistry, 2013, 56, 4749-4757. 5. Ye, B.-X.; Deng, X.; Shao, L.-D.; Lu, Y.; Xiao, R.; Liu, Y.-J.; Jin, Y.; Xie, Y.-Y.; Zhao, Y.; Luo, L.-F.; Ma, S.; Gao, M.; Zhang, L.-R.; He, J.; Zhang, W.-N.; Chen, Y.; Xia, C.-F.; Deng, M.; Liu, T.-X.; Zhao, Q.-S.*; Chen, S.-J.*; Chen, Z.*, Vibsanin B preferentially targets HSP90β, inhibits interstitial leukocyte migration, and ameliorates experimental autoimmune encephalomyelitis. The Journal of Immunology, 2015, 194, 4489-4497. 6. Zhang, Z.-J.; Nian, Y.; Zhu, Q.-F.; Li, X.-N.; Su, J.; Wu, X.-D.; Yang, J.*; Zhao, Q.-S.*, Lycoplanine A, a C16N Lycopodium alkaloid with a 6/9/5 tricyclic skeleton from Lycopodium complanatum. Organic Letters, 2017, 19, 4668-4671. 7. Dong, L.-B.; Wu, X.-D.; Shi, X.; Zhang, Z.-J.; Yang, J.; Zhao, Q.-S.*, Phleghenrines A-D and neophleghenrine A, bioactive and structurally rigid Lycopodium alkaloids from Phlegmariurus henryi. Organic Letters, 2016, 18, 4498-4501. 8. Ren, J.; Shi, X.; Li, X.-N.; Li, L.-W.; Su, J.; Shao, L.-D.*; Zhao, Q.-S.*, Synthesis of a small-molecule library with skeletal diversity from hemslecin A via the reaction-discovery strategy. Organic Letters, 2016, 18, 3948-3951. 9. Wu, X.-D.; Luo, D.; Tu, W.-C.; Deng, Z.-T.; Chen, X.-J.; Su, J.; Ji, X.*; Zhao, Q.-S.*, Hypophyllins A-D, labdane-type diterpenoids with Vasorelaxant activity from Hypoestes phyllostachya "Rosea". Organic Letters, 2016, 18, 6484-6487. 10. Gao, X.; Shao, L.-D.; Dong, L.-B.; Cheng, X.; Wu, X.-D.; Liu, F.; Jiang, W.-W.; Peng, L.-Y.; He, J.*; Zhao, Q.-S.*, Vibsatins A and B, two new tetranorvibsane-type diterpenoids from Viburnum tinus cv. variegatus. Organic Letters, 2014, 16, 980-983. 11. Dong, L.-B.; Wu, Y.-N.; Jiang, S.-Z.; Wu, X.-D.; He, J.; Yang, Y.-R.*; Zhao, Q.-S.*, Isolation and complete structural assignment of Lycopodium alkaloid cernupalhine A: theoretical prediction and total synthesis validation. Organic Letters, 2014, 16, 2700-2703. 12. Dong, L.-B.; Gao, X.; Liu, F.; He, J.; Wu, X.-D.; Li, Y.; Zhao, Q.-S.*, Isopalhinine A, a unique pentacyclic Lycopodium alkaloid from Palhinhaea cernua. Organic Letters, 2013, 15, 3570-3573. 13. Cheng, J.-T.; Liu, F.; Li, X.-N.; Wu, X.-D.; Dong, L.-B.; Peng, L.-Y.; Huang, S.-X.; He, J.*; Zhao, Q.-S.*, Lycospidine A, a new type of Lycopodium alkaloid from Lycopodium complanatum. Organic Letters, 2013, 15, 2438-2441. 14. He, J.; Chen, X.-Q.; Li, M.-M.; Zhao, Y.; Xu, G.; Cheng, X.; Peng, L.-Y.; Xie, M.-J.; Zheng, Y.-T.; Wang, Y.-P.; Zhao, Q.-S.*, Lycojapodine A, a novel alkaloid from Lycopodium japonicum. Organic Letters, 2009, 11, 1397-1400. 15. Xu, G.; Hou, A.-J.; Zheng, Y.-T.; Zhao, Y.; Li, X.-L.; Peng, L.-Y.; Zhao, Q.-S.*, Przewalskin B, a novel diterpenoid with an unprecedented skeleton from Salvia przewalskii Maxim. Organic Letters, 2007, 9 (2), 291-293. 16. Xu, G.; Hou, A.-J.; Wang, R.-R.; Liang, G.-Y.; Zheng, Y.-T.; Liu, Z.-Y.; Li, X.-L.; Zhao, Y.; Huang, S.-X.; Peng, L.-Y.; Zhao, Q.-S.*, Przewalskin A: A new C23 terpenoid with a 6/6/7 Ccarbon ring Sskeleton from Salvia przewalskii Maxim. Organic Letters, 2006, 8, 4453-4456. 17. Li, X.-L.; Cheng, X.; Yang, L.-M.; Wang, R.-R.; Zheng, Y.-T.; Xiao, W.-L.; Zhao, Y.; Xu, G.; Lu, Y.; Chang, Y.; Zheng, Q.-T.; Zhao, Q.-S.*; Sun, H.-D., Dichotomains A and B: two new highly oxygenated phenolic derivatives from Dicranopteris dichotoma. Organic Letters, 2006, 8, 1937-1940. 18. Dong, L.-B.; Yang, J.; He, J.; Luo, H.-R.; Wu, X.-D.; Deng, X.; Peng, L.-Y.; Cheng, X.; Zhao, Q.-S.*, Lycopalhine A, a novel sterically congested Lycopodium alkaloid with an unprecedented skeleton from Palhinhaea cernua. Chemical Communications, 2012, 48, 9038-9040. 19. Shi, X.; Deng, Z.-T.; Zhu, Y.; Bao, Y.; Shao, L.-D.*; Zhao, Q.-S.*, Total synthesis of (±)-cermizine B. Journal of Organic Chemistry, 2017, DOI: 10.1021/acs.joc.7b02073. 20. Shao, L.-D.; Bao, Y.; Shen, Y.; Su, J.; Leng, Y.*; Zhao, Q.-S.*, Synthesis of selective 11β-HSD1 inhibitors based on dammarane scaffold. European Journal of Medicinal Chemistry, 2017, 135, 324-338.

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