个人简介
教育背景
2004-09--2007-07 中科院昆明植物研究所 博士学位
2001-09--2004-07 云南大学 硕士学位
1997-09--2001-07 云南大学 学士学位
工作简历
2014-01~现在, 中国科学院昆明植物研究所, 研究员
2007-07~2013-12,中科院昆明植物研究所, 副研究员
研究领域
主要从事天然产物化学和药物化学研究
着重关注于两个方面的研究内容
1. 重要药用类群植物(五味子科和香茶菜属,即“一科一属”)及其内生菌中新颖次生代谢产物与生物功能的基础和应用基础研究
2. 藏药药用植物的药效物质基础及其应用研究
近期论文
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(−)-Isoscopariusin A, a Naturally Occurring Immunosuppressive Meroditerpenoid: Structure Elucidation and Scalable Chemical Synthesis, Angewandte Chemie International Edition, 2021, 通讯作者
Neuroprotective Schinortriterpenoids from Schisandra neglecta Collected in Medog County, Tibet, China, Bioorganic Chemistry, 2021, 通讯作者
Chaetolactam A, an Azaphilone Derivative from the Endophytic Fungus Chaetomium sp. g1, Journal of Organic Chemistry, 2021, 通讯作者
Targeting ubiquitin conjugating enzyme UbcH5b by a triterpenoid PC3-15 from Schisandra plants sensitizes triple-negative breast cancer cells to lapatinib, Cancer Letters, 2021, 通讯作者
High-content screening of diterpenoids from Isodon species as autophagy modulators and the functional study of their antiviral activities, Cell Biology and Toxicology, 2021, 通讯作者
A review on the relationship of mast cells and macrophages in breast cancer — Can herbs or natural products facilitate their anti-tumor effects?, Pharmacological Research, 2021, 通讯作者
Schipropins A-J, structurally diverse triterpenoids from Schisandra propinqua, Phytochemistry, 2021, 通讯作者
Phomopsisins A-C: Three new cytochalasans from the plant endophytic fungus Phomopsis sp. sh917, Tetrahedron, 2020, 通讯作者
Neuroprotective schinortriterpenoids with diverse scaffolds from Schisandra henryi, Bioorganic Chemistry, 2020, 通讯作者
ent-Kaurane-Based Diterpenoids, Dimers, and Meroditerpenoids from Isodon xerophilus, Journal of Natural Products, 2020, 通讯作者
Elucidation of the Structure of Pseudorubriflordilactone B by Chemical Synthesis, Journal of the American Chemical Society, 2020, 通讯作者
Isorugosiformins A-F, six ent-kaurane diterpenoids from Isodon rugosiformis, Fitoterapia, 2020, 通讯作者
4,5-seco-18-nor-ent-clerodanoids and their derivatives: structure elucidation, synthesis and resistant reversal activities against fluconazole-resistance Candida albicans, Tetrahedron, 2020, 通讯作者
Pestaloamides A and B, two spiro-heterocyclic alkaloid epimers from the plant endophytic fungus Pestalotiopsis sp. HS30, SCIENCE CHINA Chemistry, 2020, 通讯作者
Isopenicins A−C: Two Types of Antitumor Meroterpenoids from the Plant Endophytic Fungus Penicillium sp. sh18, Organic Letters, 2019, 通讯作者
Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin, Cell Chemical Biology, 2019, 通讯作者
Adenanthin, a Natural ent-Kaurane Diterpenoid Isolated from the Herb Isodon adenantha Inhibits Adipogenesis and the Development of Obesity by Regulation of ROS, Molecules, 2019, 通讯作者
Synergistic use of NMR computation and quantitative interproton distance analysis in the structural determination of neokadcoccitane A, a rearranged triterpenoid featuring an aromatic ring D from Kadsura coccinea, Organic Chemistry Frontiers, 2019, 通讯作者
Structurally diverse diterpenoids from Isodon ternifolius collected from three regions, Tetrahedron, 2019, 通讯作者
(+)- and (−)-Alternarilactone A: Enantiomers with a Diepoxy-Cage-like Scaffold from an Endophytic Alternaria sp., Journal of Natural Products, 2019, 通讯作者