李飞 - 中国科学院昆明植物研究所 -

个人简介

1998 - 2005 江西中医药大学药学院，学士和硕士 2005- 2008 北京大学药学院，博士 2008 - 2013 美国国立卫生研究院（NIH/NCI），博士后 2014 - 2016 美国食品药品监督管理局（FDA），研究员 2016 - 至今中国科学院昆明植物研究所，研究员

研究领域

以药理活性显著、疗效确切的天然产物为研究对象，应用代谢组学方法围绕肝病、代谢性疾病的预防与治疗开展研究，整合化学生物学、分子生物学和各种组学方法，以期发现临床安全、疗效可靠的创新天然药物。 1. 活性天然产物的成药性（ADMET）研究 2. 疗效确切的天然产物作用机理研究 3. 肝病、代谢性疾病治疗药物的代谢组学研究

近期论文

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Xiao-Nan Yang, Xue-Mei Liu, Jian-he Fang, Xu Zhu, Xiu-Wei Yang*, Xue-Rong Xiao, Jian-Feng Huang, Frank J. Gonzalez, Fei Li*. PPARα mediates the hepatoprotective effects of nutmeg. J Proteome Res, 2018, 17, 1887-1897. Rui Yang#, Qi Zhao#, Dan-Dan Hu, Xue-Rong Xiao, Jian-Feng Huang, Fei Li*. Metabolomic analysis of cholestatic liver damage in mice. Food Chem Toxicol, 2018, 120, 253-260. Fei Li, Wei-Feng Zhu, Frank J. Gonzalez*. Potential role of CYP1B1 in the development and treatment of metabolic diseases. Pharmacol Therapeut, 2017, 178, 18-30. Yang Xu, Fei Li, Munaf Zalzala, Jiesi Xu, Frank J. Gonzalez, Luciano Adorini, Yoon-Kwang Lee, Liya Yin, Yanqiao Zhang. Farnesoid X receptor activation increases reverse cholesterol transport. Hepatology, 2016, 64, 1072-1085. Yuanyuan Zhang, Fei Li, Yao Wang, Aaron Pitre, Zhongze Fang, Matthew W. Frank, Christopher Calabrese, Kristopher W. Krausz, Geoffrey Neale, Sharon Frase,Peter Vogel,Charles O. Rock,Frank J. Gonzalez, John D. Schuetz*. Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun, 2015, 6, 8186. Changtao Jiang, Chen Xie, Fei Li, Limin Zhang, Robert G. Nichols, Kristopher W. Krausz, Jinwei Cai, Yunpeng Qi, Kristopher W. Krausz Fang, Shogo Takahashi, Naoki Tanaka, Dhimant Desai, Shantu G. Amin, Istvan Albert, Andrew D. Patterson, Frank J. Gonzalez*. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J Clin Invest, 2015, 125, 386-402. Fei Li#, Changtao Jiang#, Kristopher W. Krausz, Yunfei Li, Istvan Albert, Haiping Hao, Kristin M.Fabre, James B. Mitchell, Andrew D. Patterson, Frank J. Gonzalez*. Microbiome remodeling leads to inhibition of intestinal farnesoid X receptor signaling and decreased obesity. Nat Commun, 2013, 4, 2384. Fei Li, Andrew D. Patterson, Kristopher W. Krausz, Changtao Jiang, Huichang Bi, Anastasia L. Sowers, John A. Cook, James B. Mitchell, Frank J. Gonzalez*. Metabolomics reveals that tumor xenografts induce liver dysfunction. Mol Cell Proteomics, 2013, 12, 2126-2135. Fei Li, Andrew D. Patterson, Kristopher W. Krausz, Bernhard Dick, Felix J. Frey, Frank J. Gonzalez, Jeffrey R. Idle*. Metabolomics reveals the metabolic map of procainamide in humans and mice. Biochem Pharmacol, 2012, 83, 1435-1444. Yuanyuan Zhang#, Fei Li#, Andrew D. Patterson, Yao Wang, Kristopher W. Krausz, Geoffrey Neale; Sarah Thomas, Deepa Nachagari, Peter Vogel, Mary Vore, Frank J. Gonzalez, John D. Schuetz*. Abcb11 deficiency induces cholestasis coupled to impaired β-Fatty acid oxidation in mice. J Biol Chem, 2012, 287, 24784-24794.