Seeliger, Jessica - Stony Brook University

个人简介

Jessica received her A. B. in Chemistry from Harvard University in 2000, her MPhil in Chemistry from the University of Cambridge in 2001, and her Ph. D. in Chemistry from Stanford University in 2007. She moved to the University of California, Berkeley, in 2007 as a postdoctoral fellow with Carolyn Bertozzi and in Fall 2010 started her lab in the Department of Pharmacological Sciences at Stony Brook University.

研究领域

We are applying biochemical, microbiological and biophysical methods to fundamental questions in bacterial membrane biogenesis as they relate to Mycobacterium tuberculosis, the bacterium that causes tuberculosis, and to bacterial pathogenesis in general. How is lipid biosynthesis accomplished at the cytosol-membrane interface? What are the molecular mechanisms underlying bacterial membrane assembly? How can we subvert lipid biosynthesis and membrane assembly pathways for antimicrobial therapy?

近期论文

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Van Vlack, E. R., Seeliger, J. C. (2015) Using riboswitches to regulate gene expression and define gene function in mycobacteria. Meth. Enzymol. 550, 251-265. Touchette, M. H., Holsclaw C. M., Previti, M. L., Solomon, V. C., Leary, J. A., Bertozzi, C. R., Seeliger, J. C. (2015) The rv1184c locus encodes Chp2, an acyltransferase in Mycobacterium tuberculosis polyacyltrehalose lipid biosynthesis. J. Bacteriol. 197, 201-210. Seeliger, J. C. (2012) Scientists must be taught to manage. Nature 483, 511. doi: 10.1038/483511a Seeliger, J. C., Holsclaw, C. M., Schelle, M. W., Botyzanszki, Z., Gilmore, S. A., Tully, S. E., Niederweis, M., Cravatt, B. F., Leary, J. A., Bertozzi, C. R. (2012) Elucidation and Chemical Modulation of Sulfolipid-1 Biosynthesis in Mycobacterium tuberculosis. J. Biol. Chem. 287, 7990-8000. Seeliger, J. C., Topp, S., Sogi, K. M., Previti, M. L., Gallivan, J. P., Bertozzi, C. R. (2012) A Riboswitch-Based Inducible Gene Expression System for Mycobacteria. PLoS One. 7, e29266. Topp, S., Reynoso, C. M. K., Seeliger, J. C., Goldlust, I. S., Desai, S. K., Murat, D., Shen, A., Puri, A. W., Komeili, A., Bertozzi, C. R., Scott, J. R., Gallivan, J. P. (2010) Synthetic Riboswitches that Induce Gene Expression in Diverse Bacterial Species. Appl. Environ. Microbiol. 76, 7881-7884. Chuang, J. I., Boxer, S. G., Holten, D., Kirmaier, C. (2008) Temperature Dependence of Electron Transfer to the M-side Bacteriopheophytin in Rhodobacter capsulatus Reaction Centers. J. Phys. Chem. B. 112, 5487-5499. Fafarman, A., Webb, L. J., Chuang J. I., Boxer S. G. (2006) Site-Specific Conversion of Cysteine Thiols into Thiocyanate Creates an IR Probe for Electric Fields in Proteins. J. Amer. Chem. Soc. 128, 13356-13357. Chuang, J. I., Boxer, S. G., Holten, D., Kirmaier, C. (2006) High Yield of M-side Electron Transfer in Mutants of Rhodobacter capsulatus Reaction Centers Lacking the Initial Electron Acceptor Bacteriopheophytin. Biochemistry 45, 3845-3851. Khan, F., Chuang, J. I., Gianni, S., Fersht, A. R. (2003) The kinetic pathway of folding of barnase. J. Mol. Biol. 333, 169-86 Craig, N.C., Chuang, J. I., Nwofor, C. C., Oertel, C. M. (2000) Synthesis and vibrational spectroscopy of 1,1,2,2-tetrafluoroethane and its 13C2- and d2- isotopomers. J. Phys. Chem. A 104, 10092-103.