White, M. Christina - University of Illinois at Urbana-Champaign

个人简介

Professor M. Christina White received her B.A. with highest honors in Biochemistry from Smith College in 1992 and her Ph.D. from Johns Hopkins University in 1998. After a postdoctoral fellowship at Harvard University, she joined the faculty there in 2002. In 2005 she joined the faculty at the University of Illinois at Urbana-Champaign. Her research interests are in the field of organic synthesis with an emphasis on the discovery of transition-metal mediated reactions that address unsolved problems in organic methodology. Current Appointment: University of Illinois, Urbana-Champaign, IL August 2019-present Lycan Professor of Chemistry Previous Appointments: University of Illinois, Urbana-Champaign, IL Professor of Chemistry July 2011-August 2019 Assistant Professor of Chemistry July 2005-July 2009 Associate Professor of Chemistry August 2009-July 2011 Harvard University, Cambridge, MA August 2002-June 2005 Assistant Professor of Chemistry Education: NIH Postdoctoral Fellow Dept. of Biology Dept. of Chemistry and Chemical Biology Johns Hopkins University Harvard University Advisor: Christian B. Anfinsen Advisor: Professor Eric N. Jacobsen August 1992-December 1993 January 1999-2002 Ph.D. in Organic Chemistry B.A. with highest honors in Biochemistry ACS Predoctoral Fellow Smith College Dept. of Chemistry Advisor: Professor Stuart Rosenfeld Johns Hopkins University August 1988-1992 Advisor: Professor Gary H. Posner January 1994-December 1998

研究领域

Among the frontier challenges in chemistry in the 21st century are (1) increasing control of chemical reactivity and (2) synthesizing complex molecules with higher levels of efficiency. Although it has been well demonstrated that given ample time and resources, highly complex molecules can be synthesized in the laboratory, too often current methods do not allow chemists to match the efficiency achieved in Nature. This is particularly relevant for molecules with non-polypropionate-like oxidation patterns (e.g. Taxol). Traditional organic methods for installing oxidized functionality rely heavily on acid-base reactions that require extensive functional group manipulations (FGMs) including wasteful protection-deprotection sequences. Due to their ubiquity in complex molecules and inertness to most organic transformation, C—H bonds have typically been ignored in the context of methods development for total synthesis. My laboratory has initiated a program to develop highly selective oxidation methods, similar to those found in Nature, for the direct installation of oxygen, nitrogen and carbon functionalities into allylic and aliphatic C—H bonds of complex molecules and their intermediates. Unlike Nature which uses elaborate enzyme active sites, we rely on the subtle electronic and steric interactions between C—H bonds and small molecule transition metal complexes to achieve high selectivities. Gaining a fundamental and predictive understanding of these interactions through mechanistic studies is one of the main goals and discovery engines of our research. Using these methods, my group aims to develop novel strategies for streamlining the process of complex molecule synthesis. Collectively, we aim to change the way that complex molecules are constructed by redefining the reactivity principles of C—H bonds in complex molecule settings. organic synthesis with an emphasis on the discovery of transition-metal mediated reactions that address unsolved problems in organic methodology

近期论文

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Palladium-catalyzed cross-coupling of alcohols with olefins by positional tuning of a counteranion Kaster, S. H. M., Zhu, L., Lyon, W. L., Ma, R., Ammann, S. E. & White, M. C., Sep 6 2024, In: Science. 385, 6713, p. 1067-1076 10 p. A preparative small-molecule mimic of liver CYP450 enzymes in the aliphatic C–H oxidation of carbocyclic N-heterocycles Chambers, R. K., Weaver, J. D., Kim, J., Hoar, J. L., Krska, S. W. & Christina White, M., Jul 18 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 29, e2300315120. Allylic C–H amination cross-coupling furnishes tertiary amines by electrophilic metal catalysis Ali, S. Z., Budaitis, B. G., Fontaine, D. F. A., Pace, A. L., Garwin, J. A. & White, M. C., Apr 15 2022, In: Science. 376, 6590, p. 276-283 8 p. Chemoselective methylene hydroxylation in aromatic molecules White, M. C. (Inventor) & Zhao, J. (Inventor), Mar 30 2021, U.S. Patent No. 10961266 Late-Stage Intermolecular Allylic C-H Amination Ide, T., Feng, K., Dixon, C. F., Teng, D., Clark, J. R., Han, W., Wendell, C. I., Koch, V. & White, M. C., Sep 22 2021, In: Journal of the American Chemical Society. 143, 37, p. 14969-14975 7 p. Chemoselective Tertiary C−H Hydroxylation for Late-Stage Functionalization with Mn(PDP)/Chloroacetic Acid Catalysis Chambers, R. K., Zhao, J., Delaney, C. P. & White, M. C., Jan 23 2020, In: Advanced Synthesis and Catalysis. 362, 2, p. 417-423 7 p. Late-stage oxidative C(sp 3)–H methylation Feng, K., Quevedo, R. E., Kohrt, J. T., Oderinde, M. S., Reilly, U. & White, M. C., Apr 30 2020, In: Nature. 580, 7805, p. 621-627 7 p. Manganese (III) catalyzed C—H aminations White, M. C. (Inventor), Clark, J. R. (Inventor), Feng, K. (Inventor), Sookezian, A. (Inventor) & Wendell, C. (Inventor), Apr 7 2020, U.S. Patent No. 10611786 Chemoselective methylene oxidation in aromatic molecules Zhao, J., Nanjo, T., de Lucca, E. C. & White, M. C., Mar 1 2019, In: Nature Chemistry. 11, 3, p. 213-221 9 p. Sulfoxide ligand metal catalyzed oxidation of olefins White, M. C. (Inventor), Ammann, S. E. (Inventor), Liu, W. (Inventor) & Ma, R. (Inventor), Apr 23 2019, U.S. Patent No. 10266503 Synthesis of anti-1,3 Amino Alcohol Motifs via Pd(II)/SOX Catalysis with the Capacity for Stereodivergence Ma, R., Young, J., Promontorio, R., Dannheim, F. M., Pattillo, C. C. & White, M. C., Jun 19 2019, In: Journal of the American Chemical Society. 141, 24, p. 9468-9473 6 p. Aliphatic C-H Oxidations for Late-Stage Functionalization White, M. C. & Zhao, J., Oct 31 2018, In: Journal of the American Chemical Society. 140, 43, p. 13988-14009 22 p. Asymmetric Allylic C-H Alkylation via Palladium(II)/ cis-ArSOX Catalysis Liu, W., Ali, S. Z., Ammann, S. E. & White, M. C., Aug 29 2018, In: Journal of the American Chemical Society. 140, 34, p. 10658-10662 5 p. Catalyst-controlled aliphatic C—H oxidations White, M. C. (Inventor) & Gormisky, P. E. (Inventor), Mar 27 2018, U.S. Patent No. 9925528 C-H to C-N Cross-Coupling of Sulfonamides with Olefins Ma, R. & Christina White, M., Mar 7 2018, In: Journal of the American Chemical Society. 140, 9, p. 3202-3205 4 p. Manganese-catalysed benzylic C(sp 3)-H amination for late-stage functionalization Clark, J. R., Feng, K., Sookezian, A. & White, M. C., Jun 1 2018, In: Nature Chemistry. 10, 6, p. 583-591 9 p. Catalytic C(sp3)-H alkylation via an iron carbene intermediate Griffin, J. R., Wendell, C. I., Garwin, J. A. & White, M. C., Oct 4 2017, In: Journal of the American Chemical Society. 139, 39, p. 13624-13627 4 p. General catalyst for C-H functionalization White, M. C. (Inventor), Zhao, J. (Inventor), Paradine, S. M. (Inventor), Griffin, J. R. (Inventor) & Petronico, A. L. (Inventor), Sep 26 2017, U.S. Patent No. 9770711 Remote, Late-Stage Oxidation of Aliphatic C-H Bonds in Amide-Containing Molecules Nanjo, T., De Lucca, E. C. & White, M. C., Oct 18 2017, In: Journal of the American Chemical Society. 139, 41, p. 14586-14591 6 p. Aerobic Linear Allylic C-H Amination: Overcoming Benzoquinone Inhibition Pattillo, C. C., Strambeanu, I. I., Calleja, P., Vermeulen, N. A., Mizuno, T. & White, M. C., Feb 3 2016, In: Journal of the American Chemical Society. 138, 4, p. 1265-1272 8 p. Base-Metal Catalysis: Embrace the Wild Side White, M. C., Jul 28 2016, In: Advanced Synthesis and Catalysis. 358, 15, p. 2364-2365 2 p. Enantioselective Allylic C−H Oxidation of Terminal Olefins to Isochromans by Palladium(II)/Chiral Sulfoxide Catalysis Ammann, S. E., Liu, W. & White, M. C., Aug 8 2016, In: Angewandte Chemie - International Edition. 55, 33, p. 9571-9575 5 p. Oxidative diversification of amino acids and peptides by small-molecule iron catalysis Osberger, T. J., Rogness, D. C., Kohrt, J. T., Stepan, A. F. & White, M. C., Aug 1 2016, In: Nature. 537, 7619, p. 214-219 6 p.