严冬 - 中国科学院大学 - 生命科学学院

个人简介

招生专业 071010-生物化学与分子生物学招生方向昆虫发育信号途径教育背景 2002-09--2009-06 美国辛辛那提大学博士 1996-09--2000-07 南京大学学士工作简历 2016-08~现在, 上海植物生理生态研究所, 研究员 2010-06~2016-07,美国哈佛大学医学院, 博士后发表著作（1） Generating and Interpretation of Morphogen Gradients （Shaping morphogen gradient by proteoglycans.）, Cold Spring Harbor Laboratory Press, 2010-03, 第 1 作者

近期论文

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（1） Xio is a novel component of the Drosophila sex determination pathway and RNA N6-methyladenosine methyltransferase complex, PNAS, 2018, 通讯作者（2） The m6A pathway facilitates sex determination in Drosophila, Nature Communications, 2017, 其他（合作组作者）（3） Spenito is required for sex determination in Drosophila melanogaster, PNAS, 2015, 第 1 作者（4） Histone H1-Mediated Epigenetic Regulation Controls Germline Stem Cell Self-Renewal by Modulating the Acetylation of H4 Lysine 16, Nature Communications, 2015, 其他（合作组作者）（5） The Transgenic RNAi Project at Harvard Medical School: Resources and Validation, Genetics, 2015, 其他（合作组作者）（6） Genome-Wide RNAi Screen Identifies Networks Involved in Intestinal Stem Cell Regulation in Drosophila, Cell Reports, 2015, 第 6 作者（7） A sharp end to sugary Wingless travels, The Journal of Cell Biology, 2014, 第 2 作者（8） A regulatory network of Drosophila germline stem cell self-renewal, Developmental Cell, 2014, 第 1 作者（9） Depleting gene activities in early Drosophila embryos with the “maternal-Gal4-shRNA” system, Genetics, 2013, 第 2 作者（10） Proteomic and functional genomic landscape of receptor tyrosine kinase and Ras/ERK signaling, Science Signaling, 2011, 第 4 作者（11） The cell-surface proteins Dally-like and Ihog differentially regulate Hedgehog signaling strength and range during development, Development, 2010, 第 1 作者（12） The core protein of glypican Dally-like determines its biphasic activity in Wingless morphogen signaling, Developmental Cell, 2009, 第 1 作者（13） Opposing roles for glypicans in Hedgehog signalling, Nature Cell Biology, 2008, 第 1 作者（14） Drosophila glypican Dally-like acts in FGF-receiving cells to modulate FGF signaling during tracheal morphogenesis, Developmental Biology, 2007, 第 1 作者（15） Drosophila Glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc, Development, 2005, 第 2 作者（16） Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis and is controlled by glypican members of heparan sulfate proteoglycans, Cell, 2004, 第 3 作者（17） Mutation of a lysine residue in a homeodomain generates dominant negative thyroid transcription factor 1, Biochemistry, 2004, 第 2 作者（18） Peroxisome proliferator-activated receptor gamma and ligands inhibit surfactant protein B gene expression in the lung, The Journal of Biological Chemistry, 2003, 第 2 作者（19） An enhancer region determines hSP-B gene expression in bronchiolar and ATII epithelial cells in transgenic mice, American Journal of Physiology Lung Cellular and Molecular Physiology, 2003, 第 4 作者