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微生物代谢调控与代谢工程

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1.Yang Y., L Zhang, H Huang, C Yang, S Yang, Y Gu*, W Jiang*. A flexible binding site architecture provides new insights into CcpA global regulation in Gram-positive bacteria. (2017) mBio 24:8(1). 2.Li J., C Wang, G Yang, Z Sun., H Guo, K Shao, Y Gu, W Jiang*, P Zhang*. Molecular mechanism of environmental D-xylose perception by a XylFII-LytS complex in bacteria. (2017) PNAS, 114(31): 8235-8241. 3.Li L., W Jiang*, Y Lu*. A novel two-component system, GluR-K, involved in glutamate sensing and uptake in Streptomyces coelicolor. (2017) J Bacteriol 199(18) e00097-17. 4.Li L., W Jiang*, Y Lu*. New strategies and approaches for engineering biosynthetic gene clusters of microbial natural products. (2017) Biotechnol Adv 35:936-949. 5.Li L., G Zheng, J Chen, M Ge, W Jiang*, Y Lu*. Multiplexed site-specific genome engineering for overproducing bioactive secondary metabolites in actinomycetes. (2017) Metab Eng 40: 80-92. 6.Meng J., R Feng, G Zheng, M Ge, Mast Y, Wohlleben W*, J Gao, W Jiang* and Y Lu*. Improvement of pristinamycin I (PI) production in Streptomyces pristinaespiralis by metabolic engineering approaches. (2017) Synth Syst Biotechnol 2:130-136. 7.He J., H Zhu, G Zheng, P Liu, J Wang, G Zhao, G Zhu*, W Jiang*, Y Lu*, Direct invovlement of the master nitrogen metabolism regulator in antibiotic Biosynthesis in Streptomyces. (2016) J Biol Chem. 291 (51) :26443. 8.Yang Y., N Lang, G Yang, S Yang, W Jiang*, Y Gu*, Improving the performance of solventogenic clostridia by reinforcing the biotin synthetic pathway. (2016) Metab Eng 35: 121-128. 9.Xue Q., Y Yang, J Chen, L Chen, S Yang, W Jiang*, Y Gu*, Roles of three AbrBs in regulating two-phase Clostridium acetobutylicum fermention.(2016)Appl Microbiol Biotechnol 100(21):9081-9089. 10.Ren C., Z Wen, Y Xu, W Jiang*, Y Gu*, Clostridia: a flexible microbial platform for the production of alcohols. (2016) Curr Opin Chem Biol 35:65-72. 11.Dun J., L Ruan, H Zhu, W Wang, G Zheng, M Ge, W Jiang* and Y Lu* , Identification of an atypical response regulator PapR6, a pathway-specific activator of pristinamycin II biosynthesis in Streptomyces pristinaespiralis. (2015) Journal of Bacteriology 197(3): 441-450. 12.Wu Y., Y Yang, C Ren, C Yang, S Yang, Y Gu*, W Jiang*, Molecular modulation of pleiotropic regulator CcpA for glucose and xylose coutilization by solvent-producing Clostridium acetobutylicum. (2015) Metab Eng 28:169-179. 13.Sun Z., Y Chen, C Yang, S Yang, Y Gu*, W Jiang*, A novel three-component system-based regulatory model for d-xylose sensing and transport in Clostridium beijerinckii. (2015) Mol Microbiol 295(4):576–589. 14.Li L., Y Zhao, L Ruan, S Yang, M Ge, W Jiang* and Y Lu* , A stepwise increase in pristinamycin II biosynthesis by Streptomyces pristinaespiralis through combinatorial metabolic engineering. (2015) Metab Eng 29:12-25. 15.Li N., J Yang, C Chai, S Yang, W Jiang*, Y Gu*, Complete genome sequence of Clostridium carboxidivorans P7T, asyngas-fermenting bacterium capable of producing long-chain alcohols. (2015) Journal of Biotechnology 211:44–45. 16.Jin L., H Zhang, L Chen, S Yang, W Jiang*, Y Gu*, Identification and combinatorial overexpression of phosphate pentose pathway genes in Clostridium acetobutylicum for enhancing D-xylose utilization . (2014) Journal of Biotechnology 173:7-9. 17.Gu Y*., Y Jiang, S Yang and W Jiang*, Utilization of economical substrate-derived carbohydrates by solventogenic clostridia: pathway dissection, regulation and engineering. (2014) Current Opinion in Biotechnology 29:124-131. 18.Yu Z., H Zhu, G Zheng ,W Jiang*, Y Lu*, A genome-wide transcriptomic analysis reveals diverse roles of the two-component system DraR-K in the physiological and morphological differentiation of Streptomyces coelicolor. (2014) Appl Microbiol Biotechnol 98:9351-9363. 19.Wang R., Yvonne Mast, J Wang, W Zhang, G Zhao, Wolfgang Wohlleben, Y Lu* and W Jiang*,Identification of two-component system AfsQ1/Q2 regulon and its cross-regulation with GlnR in Streptomyces coelicolor.(2013)Molecular Microbiology 87(1):30-48. 20.Yu Z., H Zhu, F Dang, W Zhang, Z Qin, S Yang, H Tan, Y Lu*, W Jiang*, Differential regulation of antibiotic biosynthesis by DraR-K, a novel two-component system in Streptomyces coelicolor. (2012) Molecular Microbiology 85(3):535-5562. 21.Ren C., Y Gu, Y Wu, W Zhang, C Yang, S Yang and W Jiang*, Pleiotropic Functions of Catabolite Control Protein CcpA in Butanol-producing Clostridium acetobutylicum. (2012) BMC Genomics 13:349-368. 22.Hu S., H Zheng, Y Gu, J Zhao, W Zhang, Y Yang, S Wang, G Zhao, S Yang*, W Jiang*, Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018. (2011) BMC Genomics, 12: 93. 23.Lu Y., J He, H Zhu, Z Yu, R Wang, Y Chen, W Zhang, S Yang, W Jiang*, An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor. (2011) J. Bacteriol, 193: 3020-3032. 24.Gu Y., Y Jiang, H Wu, X Liu, Z Li, J Li, H Xiao, Z Shen, H Dong, Y Yang, Y Li, W Jiang* and S.Yang*, Economical challenges to microbial producers of butanol: Feedstock, butanol ratio and titer. (2011) Biotechnol. J 6: 1348–1357. 25.Xiao H., Y Gu, Y Ning, Y Yang, W.J.Mitchell, W Jiang*, S Yang* ,Confirmation and Elimination of Xylose Metabolism Bottlenecks in Glucose Phosphoenolpyruvate-Dependent Phosphotransferase System-Deficient Clostridium acetobutylicum for Simultaneous Utilization of Glucose, Xylose, and Arabinose. ( 2011) Appl Environ Microbiol 77:7886-7895. 26.Ren C., Y Gu, S Hu, Y Wu, P Wang, Y Yang, C Yang, S Yang*, W Jiang*, Identification and inactivation of pleiotropic regulator CcpA to eliminate glucose repression of xylose utilization in Clostridium acetobutylicum. (2010) Metabolic Engineering, 12: 446-454. 27.Gu Y., Y Ding, C Ren, Z Sun, D. Rodionov, W Zhang, S Yang, C Yang, W. Jiang*, Reconstruction of xylose utilization pathway and regulons in Firmicutes. (2010) BMC Genomics, 11: 255.

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上海市微生物学会副理事长

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