潘国宇 - 中国科学院上海药物研究所 -

个人简介

工作经历 03/16/2011-至今上海药物研究所，药物安全评价中心，课题组长，研究员 03/01/2008-03/10/2011 美国诺华生物医学研究院，实验室主管，高级研究员 09/01/2007-03/01/2008 美国诺华生物医学研究院，研究员 01/01/2004-08/30/2007 美国明尼苏达大学，博士后教育经历 09/01/2000-06/01/2003 中国药科大学，药学院，药代动力学，博士 09/01/1997-06/01/2000 中国药科大学，药学院，神经药理，硕士 09/01/1992-06/01/1997 中国药科大学，药学院，药理，学士

研究领域

1.药物诱导性肝损伤（DILI）相关的药物相互作用和毒代动力学机制研究 2.新型肝样细胞系的研发，评价和在ADMET中的应用 3.治疗用细胞制品的在体分布和安全性研究 4.中草药的肝毒性机制和药物相互作用

近期论文

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1.Wang L, Ma L, Lin Y, Liu X, Xiao L, Zhang Y, Xu Y, Zhou H and Pan G*. Leflunomide increases hepatic exposure to methotrexate and its metabolite by differentially regulating multidrug resistance-associated protein Mrp2/3/4 transporters via peroxisome proliferator-activated receptor alpha activation. Mol Pharmacol. 93:563–574, 2018. 2.Shi X, Gao Y, Yan Y, Ma H, Sun L, Huang P, Ni X, Zhang L, Zhao X, Ren H, Hu D, Zhou Y, Tian F, Ji Y, Cheng X, Pan G*, Ding Y and Hui L. Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes. Cell Res. 26:206-16. 2016. 3.Ni X, Gao Y, Wu Z, Ma L, Chen C, Wang L, Lin Y, Hui L and Pan G*. Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model. Sci Rep. 6:38694. 2016. 4.Wu Z, Yao D, Ji SY, Ni X, Gao Y, Hui L and Pan G*. Optimized hepatocyte-like cells with functional drug transporters directly-reprogrammed from mouse fibroblasts and their potential in drug disposition and toxicology. Cell Physiol Biochem. 38:1815-30. 2016. 5.Ma L, Wu Z, Wang L, Zhang X, Wang J, Chen C, Ni X, Lin Y, Cao Y, Luan Y and Pan G*. Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity. Acta Pharmacol Sin. 37: 1– 10. 2016. 6.Sheng J, Tian X, Xu G, Wu Z, Chen C, Wang L, Pan L, Huang C, Pan G*. The Hepatobiliary disposition of timosaponin B2 is highly dependent on influx/efflux transporters but not metabolism. Drug Metab Dispos. 43(1): 63-72, 2015. 7.Chen C, Wu Z, Ma L, Ni X, Lin Y, Wang L, Chen K, Huang C, Pan G*.Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine. Xenobiotica. 11: 1-9, 2015. 　　 8.Guo C, He L, Yao D, A J, Cao B, Ren J, Wang G, Pan G*. Alpha-naphthylisothiocyanate modulates hepatobiliary transporters in sandwich cultured rat hepatocytes. Toxicol Lett. Volume 224, Issue 1, pp 93-100, 2014. 　　 9.Tian X, Li Z, Lin Y, Chen M, Pan G*, Huang C*. Study on the PK profiles of magnoflorine and its potential interaction in Cortex phellodendri decoction by LC-MS/MS. Anal Bioanal Chem. Volume 406, Issue 3, pp 841-849, 2014. 　　 10.He L, Yang Y, Guo C, Yao D, Liu H, Sheng J, Zhou W, Ren J, Liu X, Pan G*. Opposite regulation of hepatic breast cancer resistance protein in type 1 and 2 diabetes mellitus. Eur J Pharmacol. Volume 724, pp 185-92, 2014.